Molecular and Cellular Mechanisms in Pancreatic Cancer
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: closed (15 April 2022) | Viewed by 4266
Special Issue Editor
2. Department of Laboratory Medicine, Karolinska Institute, 171 77 Stockholm, Sweden
Interests: science; transcriptome sequencing; molecular pathology; molecular diagnostics; real-time PCR; viruses in cancers
Special Issue Information
Dear Colleagues,
Prognosis of pancreatic cancer remains very poor, and novel targeted and individualized therapeutic approaches are urgently required. Pancreatic cancer is a highly aggressive malignancy with a high mortality rate worldwide. Pancreatic ductal adenocarcinoma (PDAC) accounts for about 90% of most pancreatic cancer cases.
Given the clear importance of the tumor microenvironment (TME) in PDAC, approaches to target specific features within the TME have attracted great attention. Tumor microenvironment in PDAC is mostly composed of extracellular matrix, immune cells, growth factors, and cancer-associated fibroblasts. To improve treatment options, more detailed molecular profiling is essential to allow targeting of the TME.
Recent advances in next-generation DNA sequencing have simplified classification of the molecular pathways activated in pancreatic tumors. Additionally, spatially high-resolution RNA-sequencing approaches have allowed global mapping of in situ gene expression pathways.
Unfortunately, only a few genetic alterations in PDAC have offered therapeutically tailored treatment options. To make major steps forward, advanced treatments based on individual genetic signature are needed. Additionally, successful treatments should synergically target the tumor stroma, which is pivotal in PDAC signaling pathways.
In this Special Issue, we attempt to reflect part of the research activity in the field of pancreatic cancer. Focus is placed on data supported by molecular sciences within the field of cancer research and clinical diagnostics. We look forward to reading your contributions.
Dr. Mehran Ghaderi
Guest Editor
Manuscript Submission Information
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Keywords
- cancer
- molecular
- cellular
- pancreatic ductal adenocarcinoma
- pathway
- sequencing
- transcriptome
- treatment
