Metabolic Regulators of Psychological Stress and Brain Trauma
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 3423
Special Issue Editor
Special Issue Information
Dear Colleagues,
Small molecules or metabolites comprise a wide chemical library, including short-chain fatty acids (e.g., acetate, butyrate, etc.); bio-energy cycle products (e.g., ATP, AMP, pyruvate, lactate, etc.); microbial fermentation products (e.g., formate, succinate, etc.); lipids (e.g. choline, betaine etc.); bile acids (e.g. lithocholate, glycocholate, etc.); amino acids and polyamine; phenolic compounds (e.g. phenylacetate, benzoic acid, etc.); indolic compounds (e.g. indole, indoxyl sulfate, etc.); hormones, their precursors and derivatives (e.g. GABA, serotonin, etc.), and xenobiotics. The majority of these metabolites are the end products of biological functions; hence, systematic interrogation of the metabolite profiles can inform the longitudinal endophenotypes of disease. For instance, temporal monitoring of neuro-endocrines or energy-cycle products can score the severity of the past occurrences of immune dysfunction or energy deficiency, respectively; subsequent trend analysis can forecast the chances of disease relapse or eradication. In recent years, this knowledge has been used to explain the pathophysiology of several psychological diseases and brain trauma, which embodies the focus of this Special Issue.
We welcome original articles and review works on the following subjects:
(a) The role of metabolites and their associations with other omics, such genome, epigenome and metagenome to explain the endophenotype triggered by psychological stress and brain trauma.
(b) Chemical biomarker studies and relevant molecular underpinnings that are associated with psychological stress, brain trauma and its comorbidities.
Dr. Rasha Hammamieh
Guest Editor
Manuscript Submission Information
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Keywords
- small molecules and chemicals
- metabolomics, lipidomics, and their interdependence to other omics, such as transcriptomics, epigenomics, proteomics, metagenomics etc.
- metabolites and their endophenotypes
- neuro-endocrine systems
- biological networks and their regulators
- psychological stress and comorbidities
- disease biology and dynamics
- therapeutic targets
- biomarkers
