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The Research about Microbiome and Cancer

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".

Deadline for manuscript submissions: closed (30 September 2021) | Viewed by 5844

Special Issue Editor

Special Issue Information

Dear Colleagues,

I recently accepted an invitation to serve as the Guest Editor for a Special Issue of the International Journal of Molecular Sciences on the subject of “Microbiome and Cancer”. As is well known, the microbiome is receiving considerable attention given its implication in a host of human diseases, including cancer. Its role in response to cancer treatment is becoming more and more apparent, with evidence suggesting that modulating the gut microbiome may impact responses to a number of cancer therapies.

Based on your expertise in this field, we would like to invite you to contribute with a review or full research paper for peer-review and possible publication in this Special Issue.

It is indexed by PubMed and SCIE. Its *Impact Factor* is  4.556 (2019)

International Journal of Molecular Sciences

https://www.mdpi.com/journal/ijms

Guest Editor

Maria Gazouli

Manuscript Submission Information

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Keywords

  • cancer
  • microbiome
  • microbiota

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Published Papers (1 paper)

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Review

17 pages, 345 KiB  
Review
Gut Microbiota in Lung Cancer: Where Do We Stand?
by Konstantinos Georgiou, Blagoi Marinov, Ammad Ahmad Farooqi and Maria Gazouli
Int. J. Mol. Sci. 2021, 22(19), 10429; https://doi.org/10.3390/ijms221910429 - 27 Sep 2021
Cited by 31 | Viewed by 5191
Abstract
The gut microbiota (GM) is considered to constitute a powerful “organ” capable of influencing the majority of the metabolic, nutritional, physiological, and immunological processes of the human body. To date, five microbial-mediated mechanisms have been revealed that either endorse or inhibit tumorigenesis. Although [...] Read more.
The gut microbiota (GM) is considered to constitute a powerful “organ” capable of influencing the majority of the metabolic, nutritional, physiological, and immunological processes of the human body. To date, five microbial-mediated mechanisms have been revealed that either endorse or inhibit tumorigenesis. Although the gastrointestinal and respiratory tracts are distant physically, they have common embryonic origin and similarity in structure. The lung microbiota is far less understood, and it is suggested that the crosslink between the human microbiome and lung cancer is a complex, multifactorial relationship. Several pathways linking their respective microbiota have reinforced the existence of a gut–lung axis (GLA). Regarding implications of specific GM in lung cancer therapy, a few studies showed that the GM considerably affects immune checkpoint inhibitor (ICI) therapy by altering the differentiation of regulatory T cells and thus resulting in changes in immunomodulation mechanisms, as discovered by assessing drug metabolism directly and by assessing the host immune modulation response. Additionally, the GM may increase the efficacy of chemotherapeutic treatment in lung cancer. The mechanism underlying the role of the GLA in the pathogenesis and progression of lung cancer and its capability for diagnosis, manipulation, and treatment need to be further explored. Full article
(This article belongs to the Special Issue The Research about Microbiome and Cancer)
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