Tumor Cell Plasticity and Resistance to Therapy
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: closed (10 October 2020) | Viewed by 3903
Special Issue Editors
Interests: metastasis; chemoresistance; dormancy; phenotypic plasticity
Interests: metastasis; organ-on-a-chip; breast cancer; tumor dormancy; tumor re-emergence; inflammation
Interests: prostate cancer; cell plasticity; therapeutic resistance; metastasis; innate immune system; mesenchymal stem cells; survival signaling pathways; parenchymal interactions; hepatocytes
Special Issue Information
Dear Colleagues,
The main component of mortality from solid tumors is due to metastatic spread. This dissemination further challenges therapies as these growths often appear to be generally resistant to therapies. This is distinct from drug-specific resistance that results from adaptive mutations upon exposure. Rather, this chemo- immune-radiation and targeted therapy resistance appears to be part and parcel of the phenotypic changes that accompany the ability to disseminate. This Special Issue will focus on this challenge, discussing the multiple pathological/physiological processes involved in cancer cell plasticity and resistance. It will include perspectives on cell metabolism, extracellular vehicles/exosomes, immune cells, parenchyma, stroma, as well as models in mouse and human.
Prof. Dr. Alan Wells
Dr. Amanda M. Clark
Dr. Bo Ma
Guest Editors
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Keywords
- cell plasticity
- metastasis
- tumor microenvironment
- tumor dissemination
- tumor dormancy
- tumor re-emergence
- therapeutic resistance
- immune system
- inflammation
- extracellular vesicle
- cell metabolism
- extracellular matrix
- stromal cells
- parenchymal cells
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