Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
2.8
3.1
Journals
Inorganics
Special Issues
CO-Releasing Molecules
share announcement

CO-Releasing Molecules

A special issue of Inorganics (ISSN 2304-6740). This special issue belongs to the section "Bioinorganic Chemistry".

Deadline for manuscript submissions: closed (20 December 2016) | Viewed by 15507

Special Issue Editor

Prof. Dr. Lígia M. Saraiva

E-Mail Website
Guest Editor
Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, Av. da República (EAN), 2780-157 Oeiras, Portugal
Interests: human bacterial pathogens; antimicrobials; resistance to host innate immunity; haem biosynthesis

Special Issue Information

Dear Colleagues,

Carbon monoxide (CO) is a small molecule, known since the mid-19th century as a poison because it combines with haemoglobin to form carboxyhaemoglobin, preventing oxygen transport. However, in the 1990s, a new role emerged for carbon monoxide once it was recognized to be produced by the human haem oxygenase system, which oxidatively cleaves haem to produce CO together with biliverdin and free iron. Since then CO has been shown to activate soluble guanylate cyclase, inhibit platelet aggregation, and to function as a brain messenger, thereby eliciting a wide palette of proven and potentially useful biological and therapeutic effects. The acknowledgment of the CO cell-signalling role triggered the synthesis of a family of compounds that liberate CO in a controlled way, the so-called Carbon Monoxide Releasing Molecules (CORMs). The manifold structures and properties of CORMs emerged as a highly productive area of research with developments in a wide range of scientific disciplines from synthetic/structural chemistry to biology. More recently, the antimicrobial action of CORMs has drawn the attention of research groups to produce and test compounds with antibiotic properties.

This Special Issue invites contributions in the most recent advances of the CORMs research welcoming reviews and research articles on CORMs bio-inorganic chemistry, mechanistic insights, and applications in biological systems and medicine.

Prof. Dr. Lígia M. Saraiva
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Inorganics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Synthesis, characterization and mechanistic studies
  • Immunomodulatory and antimicrobial activity
  • Physiological processes
  • Therapeutic properties
  • Drug delivery

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (2 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

3251 KiB  
Article
Manganese(I)-Based CORMs with 5-Substituted 3-(2-Pyridyl)Pyrazole Ligands
by Ralf Mede, Steve Gläser, Benedikt Suchland, Björn Schowtka, Miles Mandel, Helmar Görls, Sven Krieck, Alexander Schiller and Matthias Westerhausen
Inorganics 2017, 5(1), 8; https://doi.org/10.3390/inorganics5010008 - 25 Jan 2017
Cited by 14 | Viewed by 7549
Abstract
The reaction of [(OC)5MnBr] with substituted 3-(2-pyridyl)pyrazoles) 2-PyPzRH (1a-l) in methanol or diethyl ether yields the yellow to orange manganese(I) complexes [(OC)3Mn(Br)(2-PyPzRH)] (2a-l), the substituents R being [...] Read more.
The reaction of [(OC)5MnBr] with substituted 3-(2-pyridyl)pyrazoles) 2-PyPzRH (1a-l) in methanol or diethyl ether yields the yellow to orange manganese(I) complexes [(OC)3Mn(Br)(2-PyPzRH)] (2a-l), the substituents R being phenyl (a), 1-naphthyl (b), 2-anthracenyl (c), 1-pyrenyl (d), 4-bromophenyl (e), 3-bromophenyl (f), duryl (g), 2-pyridyl (h), 2-furanyl (i), 2-thienyl (j), ferrocenyl (k), and 1-adamantyl (l). The carbonyl ligands are arranged facially, leading to three chemically different CO ligands due to different trans-positioned Lewis donors. The diversity of the substituent R demonstrates that this photoCORM backbone can easily be varied with a negligible influence on the central (OC)3MnBr fragment, because the structural parameters and the spectroscopic data of this unit are very similar for all these derivatives. Even the ferrocenyl complex 2k shows a redox potential for the ferrocenyl subunit which is identical to the value of the free 5-ferrocenyl-3-(2-pyridyl)pyrazole (1k). The ease of variation of the starting 5-substituted 3-(2-pyridyl)pyrazoles) offers a modular system to attach diverse substituents at the periphery of the photoCORM complex. Full article
(This article belongs to the Special Issue CO-Releasing Molecules)
►▼ Show Figures

Graphical abstract

Review

Jump to: Research

1993 KiB  
Review
Visible Light-Activated PhotoCORMs
by Emmanuel Kottelat and Zobi Fabio
Inorganics 2017, 5(2), 24; https://doi.org/10.3390/inorganics5020024 - 13 Apr 2017
Cited by 56 | Viewed by 7205
Abstract
Despite its well-known toxicity, carbon monoxide (CO) is now recognized as a potential therapeutic agent. Its inherent toxicity, however, has limited clinical applications because uncontrolled inhalation of the gas leads to severe systemic derangements in higher organisms. In order to obviate life-threatening effects [...] Read more.
Despite its well-known toxicity, carbon monoxide (CO) is now recognized as a potential therapeutic agent. Its inherent toxicity, however, has limited clinical applications because uncontrolled inhalation of the gas leads to severe systemic derangements in higher organisms. In order to obviate life-threatening effects and administer the gas by bypassing the respiratory system, CO releasing molecules (CORMs) have emerged in the last decades as a plausible alternative to deliver controlled quantities of CO in cellular systems and tissues. As stable, solid-storage forms of CO, CORMs can be used to deliver the gas following activation by a stimulus. Light-activated CORMs, known as photoCORMs, are one such example. This class of molecules is particularly attractive because, for possible applications of CORMs, temporal and spatial control of CO delivery is highly desirable. However, systems triggered by visible light are rare. Most currently known photoCORMs are activated with UV light, but red light or even infrared photo-activation is required to ensure that structures deeper inside the body can be reached while minimizing photo-damage to healthy tissue. Thus, one of the most challenging chemical goals in the preparation of new photoCORMs is the reduction of radiation energy required for their activation, together with strategies to modulate the solubility, stability and nontoxicity of the organic or organometallic scaffolds. In this contribution, we review the latest advances in visible light-activated photoCORMs, and the first promising studies on near-infrared light activation of the same. Full article
(This article belongs to the Special Issue CO-Releasing Molecules)
►▼ Show Figures

Graphical abstract

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-2
Back to TopTop