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Insects
Special Issues
Molecular Mechanisms of Insecticide Resistance
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Molecular Mechanisms of Insecticide Resistance

A special issue of Insects (ISSN 2075-4450). This special issue belongs to the section "Insect Pest and Vector Management".

Deadline for manuscript submissions: closed (31 March 2024) | Viewed by 3626

Special Issue Editor

Dr. Andrew K. Jones

E-Mail Website
Guest Editor
Department of Biological and Medical Sciences, Faculty of Health and Life Sciences, Oxford Brookes University, Oxford OX3 0BP, UK
Interests: Cys-loop ligand-gated ion channels; insecticide targets; insecticide resistance; ion channel evolution

Special Issue Information

Dear Colleagues,

We are still heavily dependent on the use of pesticides to control insect pests. However, insects surviving exposure to these insecticides is a severe issue, threatening to undermine, for example, our efforts to control vector-borne diseases and protect crops. Knowing how insecticide resistance arises can help us detect and monitor resistance and inform the development of improved/novel tools for preventing pests already resistant to currently used insecticides. This Special Issue aims to provide and bring together up-to-date knowledge of the molecular mechanisms underlying insecticide resistance, broadly categorized into behavioural, metabolic, physical, and target-site.

Dr. Andrew K. Jones
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Insects is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • insecticide resistance
  • metabolic resistance
  • behavioural resistance
  • target-site resistance
  • physical resistance
  • molecular mechanism
  • insect pest

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Published Papers (2 papers)

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Research

13 pages, 1671 KiB  
Article
Metabolic Resistance and Not Voltage-Gated Sodium Channel Gene Mutation Is Associated with Pyrethroid Resistance of Aedes albopictus (Skuse, 1894) from Cambodia
by Sébastien Marcombe, Bros Doeurk, Phoutmany Thammavong, Tuba Veseli, Christian Heafield, Molly-Ann Mills, Sedra Kako, Marcelly Ferreira Prado, Shakira Thomson, Saffron Millett, Timothy Hill, Imogen Kentsley, Shereena Davies, Geethika Pathiraja, Ben Daniels, Lucianna Browne, Miranda Nyamukanga, Jess Harvey, Lyranne Rubinstein, Chloe Townsend, Zack Allen, Christopher Davey-Spence, Adina Hupi, Andrew K. Jones and Sebastien Boyeradd Show full author list remove Hide full author list
Insects 2024, 15(5), 358; https://doi.org/10.3390/insects15050358 - 15 May 2024
Cited by 1 | Viewed by 2018
Abstract
(1) Background: In Cambodia, Aedes albopictus is an important vector of the dengue virus. Vector control using insecticides is a major strategy implemented in managing mosquito-borne diseases. Resistance, however, threatens to undermine the use of insecticides. In this study, we present the levels [...] Read more.
(1) Background: In Cambodia, Aedes albopictus is an important vector of the dengue virus. Vector control using insecticides is a major strategy implemented in managing mosquito-borne diseases. Resistance, however, threatens to undermine the use of insecticides. In this study, we present the levels of insecticide resistance of Ae. albopictus in Cambodia and the mechanisms involved. (2) Methods: Two Ae. albopictus populations were collected from the capital, Phnom Penh city, and from rural Pailin province. Adults were tested with diagnostic doses of malathion (0.8%), deltamethrin (0.03%), permethrin (0.25%), and DDT (4%) using WHO tube assays. Synergist assays using piperonyl butoxide (PBO) were implemented before the pyrethroid assays to detect the potential involvement of metabolic resistance mechanisms. Adult female mosquitoes collected from Phnom Penh and Pailin were tested for voltage-gated sodium channel (VGSC) kdr (knockdown resistance) mutations commonly found in Aedes sp.-resistant populations throughout Asia (S989P, V1016G, and F1534C), as well as for other mutations (V410L, L982W, A1007G, I1011M, T1520I, and D1763Y). (3) Results: The two populations showed resistance against all the insecticides tested (<90% mortality). The use of PBO (an inhibitor of P450s) strongly restored the efficacy of deltamethrin and permethrin against the two resistant populations. Sequences of regions of the vgsc gene showed a lack of kdr mutations known to be associated with pyrethroid resistance. However, four novel non-synonymous mutations (L412P/S, C983S, Q1554STOP, and R1718L) and twenty-nine synonymous mutations were detected. It remains to be determined whether these mutations contribute to pyrethroid resistance. (4) Conclusions: Pyrethroid resistance is occurring in two Ae. albopictus populations originating from urban and rural areas of Cambodia. The resistance is likely due to metabolic resistance specifically involving P450s monooxygenases. The levels of resistance against different insecticide classes are a cause for concern in Cambodia. Alternative tools and insecticides for controlling dengue vectors should be used to minimize disease prevalence in the country. Full article
(This article belongs to the Special Issue Molecular Mechanisms of Insecticide Resistance)
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13 pages, 761 KiB  
Article
Insecticide Susceptibilities and Enzyme Activities of Four Stink Bug Populations in Mississippi, USA
by Yuzhe Du, Shane Scheibener, Yu-Cheng Zhu, K. Clint Allen and Gadi V. P. Reddy
Insects 2024, 15(4), 265; https://doi.org/10.3390/insects15040265 - 12 Apr 2024
Cited by 2 | Viewed by 1167
Abstract
In Mississippi, the Pentatomidae complex infesting soybean is primarily composed of Euschistus servus, Nezara viridula, Chinavia hilaris, and Piezodorus guildinii. This study employed spray bioassays to evaluate the susceptibilities of these stink bugs to seven commonly used formulated insecticides: [...] Read more.
In Mississippi, the Pentatomidae complex infesting soybean is primarily composed of Euschistus servus, Nezara viridula, Chinavia hilaris, and Piezodorus guildinii. This study employed spray bioassays to evaluate the susceptibilities of these stink bugs to seven commonly used formulated insecticides: oxamyl, acephate, bifenthrin, λ-cyhalothrin, imidacloprid, thiamethoxam, and sulfoxaflor. Stinks bugs were collected from soybeans in Leland, MS, USA during 2022 and 2023, as well as from wild host plants in Clarksdale, MS. There was no significant difference in the susceptibility of C. hilaris to seven insecticides between two years, whereas P. guildinii showed slightly increased susceptibility to neonicotinoids in 2023. Among all four stink bug species, susceptibility in 2022 was ranked as P. guildinii ≤ C. hilaris ≈ N. viridula, while in 2023, it was ranked as P. guildinii ≤ C. hilaris ≤ E. Servus. Additionally, populations of E. servus and P. guildinii collected from Clarksdale exhibited high tolerance to pyrethroids and neonicotinoids. Moreover, populations of E. servus and P. guildinii from SIMRU-2022 and Clarksdale-2023 showed elevated esterase and cytochrome P450 activity, respectively. These findings from spray bioassays and enzyme activity analyses provide a baseline for monitoring insecticide resistance in Pentatomidae and can guide insecticide resistance management strategies for Mississippi soybean. Full article
(This article belongs to the Special Issue Molecular Mechanisms of Insecticide Resistance)
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