Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
5.7
3.0
Journals
JCM
Special Issues
Clinical Challenges in Endocarditis—2nd Edition
share announcement

Clinical Challenges in Endocarditis—2nd Edition

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiovascular Medicine".

Deadline for manuscript submissions: closed (10 July 2024) | Viewed by 1201

Special Issue Editor

Dr. Antonio Salsano

E-Mail Website
Guest Editor
1. Division of Cardiac Surgery, Ospedale Policlinico San Martino, University of Genoa, Genova, Italy
2. Department of Integrated Surgical and Diagnostic Sciences (DISC), University of Genoa, Genova, Italy
Interests: cardiovascular surgery; infective endocarditis; heart valves pathology; infections after surgery
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

I am pleased to invite you to contribute to this Special Issue entitled “Clinical Challenges in Endocarditis—2nd Edition”. For more details on the first volume, in which we published four papers, please visit
https://www.mdpi.com/journal/jcm/special_issues/Clinical_Endocarditis

Infectious endocarditis (IE) is a fatal and debilitating disease, and has been a growing problem in the last decade. It is estimated that IE affects 3–7.5 people per 100,000 person years, and its incidence is reported to be increasing in some parts of the world. IE more frequently affects men of around 60 years of age, with staphylococcal and enterococcal IE being the most frequent. Oral streptococcal endocarditis is less frequent, and its incidence has not increased since the implementation of the 2009 and 2015 recommendations restricting indications for antibiotic prophylaxis. There has been considerable focus on new methods of early diagnosis, such as PET or CT scans, which are now used in several countries. The prognosis of IE is still unacceptably poor, and more aggressive management of this deadly disease remains necessary. For this Special Issue, we encourage the submission of studies that investigate clinical challenges involving IE.

Dr. Antonio Salsano
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cardiovascular surgery
  • infective endocarditis
  • heart valves pathology
  • diagnosis
  • management
  • therapy

Related Special Issue

Published Papers (2 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

10 pages, 398 KiB  
Article
Performance of Risk Scores in Predicting Infective Endocarditis in Patients with Staphylococcus aureus Bacteraemia in a Prospective Asian Cohort
by Jinghao Nicholas Ngiam, Matthew Chung Yi Koh, Sophia Archuleta, Dale Fisher, Louis Yi-Ann Chai, Ching-Hui Sia, William K. F. Kong and Paul Anantharajah Tambyah
J. Clin. Med. 2024, 13(10), 2947; https://doi.org/10.3390/jcm13102947 - 16 May 2024
Viewed by 630
Abstract
Background: Several risk scores have been derived to predict the risk of infective endocarditis (IE) amongst patients with Staphylococcus aureus bacteraemia (SAB), which helps to guide clinical management. Methods: We prospectively studied 634 patients admitted with SAB. The cohort was stratified [...] Read more.
Background: Several risk scores have been derived to predict the risk of infective endocarditis (IE) amongst patients with Staphylococcus aureus bacteraemia (SAB), which helps to guide clinical management. Methods: We prospectively studied 634 patients admitted with SAB. The cohort was stratified into those with or without IE, and the PREDICT Day 1, Day 5 and VIRSTA scores were tabulated. Area under the receiver operating characteristic (AUC) curves were constructed to compare the performance of each score. Results: Of the 634 patients examined, 36 (5.7%) had IE. These patients were younger (51.6 ± 20.1 vs. 59.2 ± 18.0 years, p = 0.015), tended to have community acquisition of bacteraemia (41.7% vs. 17.9%, p < 0.001), and had persistent bacteraemia beyond 72 h (19.4% vs. 6.0%, p = 0.002). The VIRSTA score had the best performance in predicting IE (AUC 0.76, 95%CI 0.66–0.86) compared with PREDICT Day 1 and Day 5. A VIRSTA score of <3 had the best negative predictive value (97.5%), compared with PREDICT Day 1 (<4) and Day 5 (<2) (94.3% and 96.6%, respectively). Conclusions: Overall, the risk scores performed well in our Asian cohort. If applied, 23.5% of the cohort with a VIRSTA ≥ 3 would require TEE, and a score of <3 had an excellent negative predictive value. Full article
(This article belongs to the Special Issue Clinical Challenges in Endocarditis—2nd Edition)
►▼ Show Figures

Figure 1

Review

Jump to: Research

13 pages, 1663 KiB  
Review
Contemporary Role of Positron Emission Tomography (PET) in Endocarditis: A Narrative Review
by Antonio Maria Sammartino, Giovanni Battista Bonfioli, Francesco Dondi, Mauro Riccardi, Francesco Bertagna, Marco Metra and Enrico Vizzardi
J. Clin. Med. 2024, 13(14), 4124; https://doi.org/10.3390/jcm13144124 - 15 Jul 2024
Viewed by 310
Abstract
Endocarditis, a serious infectious disease, remains a diagnostic challenge in contemporary clinical practice. The advent of advanced imaging modalities has contributed significantly to the improved understanding and management of this complex disease. 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) imaging has shown remarkable potential [...] Read more.
Endocarditis, a serious infectious disease, remains a diagnostic challenge in contemporary clinical practice. The advent of advanced imaging modalities has contributed significantly to the improved understanding and management of this complex disease. 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) imaging has shown remarkable potential in improving the diagnostic accuracy of endocarditis. In the update of the Modified Duke Criteria, in 2023, The International Society for Cardiovascular Infectious Diseases (ISCVID) Working Group recognized specific 18F-FDG PET/CT findings as a major diagnostic criterion, particularly in patient with prosthetic valve endocarditis. The ability of PET to visualize metabolic activity allows for the identification of infective foci and could differentiate between infective and non-infective processes. This review examines the clinical utility of PET in differentiating infective endocarditis from other cardiovascular pathologies, highlighting its sensitivity and specificity in detecting native and prosthetic valve infections, including patients with transcatheter aortic valve implantation (TAVI), cardiac implantable devices (CIEDs), and left ventricular assistance devices (LVAD). Also, practical aspects and indications are illustrated to optimize the quality of imaging and reduce potential false positive results. In conclusion, the current use of PET in endocarditis has become a valuable diagnostic tool; as technological advances continue, PET will play an increasingly important role in the multidisciplinary approach to the management of endocarditis. Full article
(This article belongs to the Special Issue Clinical Challenges in Endocarditis—2nd Edition)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-2
Back to TopTop