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Updates on Cardiac Pacing and Electrophysiology
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Updates on Cardiac Pacing and Electrophysiology

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiology".

Deadline for manuscript submissions: 25 April 2025 | Viewed by 1318

Special Issue Editor

Prof. Dr. Axel Brandes

E-Mail Website
Guest Editor
1. Department of Regional Health Research, Faculty of Health Sciences, University of Southern Denmark, Esbjerg, Denmark
2. Department of Cardiology, Esbjerg Hospital—University Hospital of Southern Denmark, Esbjerg, Denmark
Interests: atrial fibrillation; pacemakers; electrocardiography; pharmacology; cardiology; heart failure; echocardiography; clinical cardiology; cardiomyopathies

Special Issue Information

Dear Colleagues,

In recent years, substantial progress has been made in cardiac pacing and clinical electrophysiology. New technologies and innovative approaches have emerged and entered the clinical arena. Some have already become established treatment options, while others are still under development, and more evidence from clinical studies is warranted.

This Special Issue will provide state-of-the-art novel results of pacemaker and implantable cardioverter–defibrillator therapy, including conduction system pacing, leadless pacemakers, extravascular ICD and lead extraction. Moreover, we will provide a comprehensive state of the art of the invasive treatment of supraventricular and ventricular tachycardia, including new diagnostic tools and treatment modalities, as well as clinical results. This will also include cardio-neuro ablation for the treatment of non-cardiac syncope.

Researchers in the field of cardiac pacing and clinical electrophysiology are encouraged to submit review articles giving a critical appraisal of the current status of new, innovative approaches and novel technologies, as well as original articles presenting clinical outcome studies within the field.

Prof. Dr. Axel Brandes
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pacemaker
  • conduction system pacing
  • leadless pacemaker
  • implantable cardioverter–defibrillator
  • ICD
  • extravascular ICD
  • S-ICD
  • lead extraction
  • supraventricular tachycardia
  • ventricular tachycardia
  • cardio-neuro ablation

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

11 pages, 1337 KiB  
Article
Impact of Atrial Lead Position on Functional Cardiac Parameters in Patients Requiring Dual-Chamber Pacemaker Implantation
by Sarah X. Gharibeh, Valerie Jochmann, Istvan Szendey, Peter Jirak, Albert Topf, Dorothee Ladage, Uta C. Hoppe, Lars Eckardt, Emmanuel Chorianopoulos, Lukas J. Motloch and Robert Larbig
J. Clin. Med. 2025, 14(7), 2278; https://doi.org/10.3390/jcm14072278 - 27 Mar 2025
Viewed by 145
Abstract
Background: In patients requiring dual-chamber pacemaker (DDD) implantation, optimal atrial lead position remains a matter of debate. While most centers prefer implantation in the right atrial appendage position (Non-BB-P), due to a speculated favorable impact on atrial conduction characteristics, often, a Bachman bundle [...] Read more.
Background: In patients requiring dual-chamber pacemaker (DDD) implantation, optimal atrial lead position remains a matter of debate. While most centers prefer implantation in the right atrial appendage position (Non-BB-P), due to a speculated favorable impact on atrial conduction characteristics, often, a Bachman bundle pacing (BB-P) is recommended. However, data investigating clinical outcomes in these patients are still rare. Methods: To evaluate this issue, in this retrospective single-center study, one-year clinical follow-up, pacemaker interrogations and available echocardiography findings in 301 consecutive patients (BB-P: age 76 ± 10 years, 46.7% female, n = 169; Non-BB-P: 77.6 ± 9 years, 50% female, n = 132, p = n.s.) scheduled for dual-chamber implantation were analyzed. Results: During follow-up, the incidence of atrial fibrillation (AF) remained similar in both groups (BB-P: 38.3%, n = 154 vs. Non-BB-P: 34.2%, n = 117 p = n.s.). However, we detected significantly more mode switch episodes in the BB-P group (BB-P: 51.9%, n = 154 vs. Non-BB-P: 38.8%, n = 116, p = 0.032). Furthermore, left ventricular functional parameters, including left ventricular ejection fraction (BB-P: 57.1 ± 8.4%, n = 60 vs. Non-BB-P: 56.0 ± 9.6, n = 45 p = n.s.) and incidence of diastolic dysfunction (BB-P: 55.2%, n = 67 vs. Non-BB-P: 38.3%, n = 47, p = n.s.), as well as the rate of left (BB-P: 58.8%, n = 68 vs. Non-BB-P: 42.0%, n = 50, p = n.s.) and right atrial dilatation (BB-P: 27.9%, n = 68 vs. Non-BB-P: 28.0%, n = 50 p = n.s.), were not significantly affected by the atrial lead position. However, stimulated p-waves were significantly shorter in BB-P vs. Non-BB-P (BB-P: 132.9 ± 23.7 ms, n = 127 vs. Non-BB-P: 139.6 ± 23.4 ms, n = 93, p = 0.031). Conclusions: In patients requiring dual-chamber implantation, the position of the atrial lead significantly altered atrial conduction, but this did not seem to affect left ventricular function parameters or the occurrence of atrial fibrillation within our follow-up period. Interestingly, we even detected more mode switch episodes in the BB-P group, hinting at an even proarrhythmic potential of BB-P. On the other hand, we found a decreased ventricular stimulation percentage in BB-P vs. Non-BB-P. Further studies should investigate the impact of Bachmann bundle pacing on clinical outcomes. Full article
(This article belongs to the Special Issue Updates on Cardiac Pacing and Electrophysiology)
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12 pages, 2206 KiB  
Article
Leadless Pacemaker vs. Transvenous Pacemaker in End Stage Kidney Disease: Insights from the Nationwide Readmission Database
by Sajog Kansakar, Azka Naeem, Norbert Moskovits, Dhan Bahadur Shrestha, Jurgen Shtembari, Monodeep Biswas, Ghanshyam Shantha, Binaya Basyal, James Storey and Daniel Katz
J. Clin. Med. 2025, 14(1), 202; https://doi.org/10.3390/jcm14010202 - 2 Jan 2025
Viewed by 813
Abstract
Background: Leadless pacemakers offer a safe and effective alternative pacing strategy. However, limited data are available for patients with end stage renal disease (ESRD), a population of significant relevance. Methods: Using the Nationwide Readmission Database, we extracted data from all adult patients [...] Read more.
Background: Leadless pacemakers offer a safe and effective alternative pacing strategy. However, limited data are available for patients with end stage renal disease (ESRD), a population of significant relevance. Methods: Using the Nationwide Readmission Database, we extracted data from all adult patients with ESRD who underwent traditional transvenous or leadless pacemaker implantation between 2016 and 2021. We compared in-hospital mortality, 30-day readmission rates, complication rates, and healthcare resource utilization between the two cohorts. Results: A total of 6384 (81.2%) patients were included in the transvenous pacemaker cohort, and 1481(18.8%) patients were included in the leadless pacemaker cohort. In patients with ESRD, leadless pacemaker implantation was linked to higher in-hospital complications when compared to transvenous pacemakers. These included the need for blood transfusion (aOR 1.85, 95% CI 1.32–2.60, p < 0.01), vascular complications (aOR 3.6, CI 1.40–9.26, p = 0.01), and cardiac complications (aOR 4.12, CI 1.70–9.98, p < 0.01). However, there were no differences between the two groups in terms of in-hospital mortality and 30-day readmission rates. The median length of stay was longer for leadless pacemaker implantation than transvenous pacemaker implantation (5 days vs. 4 days, p < 0.01). The total hospitalization charges were also higher ($139,826 vs. $93,919, p < 0.01). Conclusions: Although previous studies have demonstrated lower long-term complication rates with leadless pacemakers than transvenous pacemakers, our analysis shows a higher risk of short-term in-hospital complications in ESRD patients, though no differences in in-hospital mortality and 30-day readmissions. Full article
(This article belongs to the Special Issue Updates on Cardiac Pacing and Electrophysiology)
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