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Inflammatory Bowel Diseases in 2024 and Beyond: From Diagnosis to...
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Inflammatory Bowel Diseases in 2024 and Beyond: From Diagnosis to Treatment

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Gastroenterology & Hepatopancreatobiliary Medicine".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 3296

Special Issue Editors

Dr. Amalia Di Petrillo

E-Mail Website
Guest Editor
Department of Medical Science and Public Health, University of Cagliari, 09042 Monserrato, Italy
Interests: inflammatory bowel disease; inflammation; enzymatic activity; nutrition; natural extracts; immunotarget
Special Issues, Collections and Topics in MDPI journals
Dr. Sara Onali

E-Mail Website
Guest Editor
Department of Medical Science and Public Health, University of Cagliari, 09124 Cagliari, Italy
Interests: inflammatory bowel disease; crohn disease; ulcerative colitis; inflammation; clinical trial; nutrition; target therapy

Special Issue Information

Dear Colleagues,

We are delighted to introduce a Special Issue focusing on inflammatory bowel diseases (IBDs) in 2024 and beyond, with a dedicated exploration of diagnosis and treatment.

This compilation of scientific research aims to provide an in-depth overview of the current state of research and therapies for IBDs, offering a clear insight into future perspectives. 

IBDs are chronic intestinal disorders typically categorized as Crohn's disease and ulcerative colitis. Diagnosing and treating such conditions pose significant challenges for healthcare professionals due to the intrinsic complexity of clinical presentations and the causal factors involved.

This Special Issue extensively explores the latest advancements in diagnostic techniques, embracing cutting-edge technologies and innovative methodologies. Authors are invited to delve into the intricate landscape of diagnostic challenges, presenting advanced solutions poised to elevate the precision and swiftness of IBD diagnosis.

Additionally, this issue aims to critically examine current and emerging therapies for IBD, offering insightful analyses of conventional treatments. It will introduce fresh perspectives on personalized therapies and pioneering strategies, including avant-garde approaches like gene therapy and personalized medicine.

Addressing crucial aspects of long-term IBD management, this Special Issue will encompass associated complications and their profound impacts on patients' quality of life. The authors aim to provide a lucid perspective on integrating existing therapies with complementary approaches, enriching the overall care paradigm for individuals facing IBD.

In conclusion, this Special Issue stands as an inclusive platform for disseminating the latest research and breakthroughs in the realm of inflammatory bowel diseases.

This Special Issue aims to include various article types, including original research articles, comprehensive reviews, impactful communications, and more.

Potential topics for submission include the following:

  1. Advanced diagnostic techniques in IBD: novel imaging and biomarker approaches;
  2. Personalized therapies for IBD: from precision medicine to gene therapy;
  3. Innovations in endoscopic diagnosis and treatment of inflammatory bowel diseases;
  4. Exploring the interplay of gut microbiota in IBD pathogenesis and therapeutic interventions;
  5. Long-term complications of IBD: managing challenges and enhancing the quality of life;
  6. Updates on the surgical management of IBD: techniques, indications, and outcomes;
  7. Patient-centric approaches in IBD care: improving adherence and quality of life;
  8. The role of diet therapy in IBD: efficacy, challenges, and dietary interventions;
  9. Combined therapies in IBD and comorbid conditions: an integrated approach;
  10. Real-world data on the efficacy and safety of biologic therapies in inflammatory bowel diseases.

We encourage authors to contribute their expertise and insights to create a comprehensive body of knowledge that can significantly advance our understanding and management of IBD. 

Dr. Amalia Di Petrillo
Dr. Sara Onali
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • inflammatory bowel disease
  • Crohn’s disease
  • ulcerative colitis
  • target therapy
  • nutrition
  • early diagnosis
  • inflammatory biomarkers

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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10 pages, 593 KiB  
Article
Evaluation of the BIOSECURE Questionnaire in Patients Followed for Inflammatory Rheumatological and Gastrointestinal Diseases Through the Analysis of This Questionnaire
by Myriam Beissat, Marion Geoffroy, Loïs Bolko, Ambre Hittinger, Morgane Bonnet, Guillaume Cadiot and Jean Hugues Salmon
J. Clin. Med. 2025, 14(3), 687; https://doi.org/10.3390/jcm14030687 - 22 Jan 2025
Viewed by 623
Abstract
Therapeutic education (TE) plays a central role in the management of chronic inflammatory rheumatic diseases and inflammatory bowel disease. The BIOSECURE questionnaire was developed and validated in 2012 to assess self-management and patient safety, initially in rheumatology. Objectives: The aim of our [...] Read more.
Therapeutic education (TE) plays a central role in the management of chronic inflammatory rheumatic diseases and inflammatory bowel disease. The BIOSECURE questionnaire was developed and validated in 2012 to assess self-management and patient safety, initially in rheumatology. Objectives: The aim of our study was to assess the knowledge of patients followed in both rheumatology and gastroenterology regarding their treatment through the BIOSECURE questionnaire. The secondary objective was to identify factors associated with a low level of knowledge according to the BIOSECURE questionnaire. Methods: This was a descriptive observational study, conducted in a single center at the Reims University Hospital between January 2023 and April 2024. The population was divided into quartiles. Participation in therapeutic education (TE) included receiving brochures about their disease or treatment and/or participation in group or individual TE sessions. We compared the patients with the lowest scores to those with the highest scores. Results: The study population consisted of 312 patients, including 32.05% with rheumatoid arthritis (RA) and 29.81% with Crohn’s disease. In our population, 82.03% had participated in therapeutic education, which included a TE session and/or the distribution of brochures about their disease and/or treatment. The median [IQR] BIOSECURE score was 71.04/100 [IQR 61.77–81.9]. When comparing patients with a low BIOSECURE score (<61.77) to those with a high score (>81.9), univariate factors associated with a low score were older age (p = 0.02), less participation in therapeutic education (p = 0.01), shorter duration of targeted therapy (p = 0.01), and lower level of education (p < 0.05). Conversely, patients who had received therapeutic education had a higher BIOSECURE score (p = 0.01). There was no difference in BIOSECURE scores based on place of residence, location of patient follow-up, route of administration, or type of inflammatory disease. In a multivariate analysis with a model including age, TE participation, and duration of targeted therapy, the results remained significant (p < 0.05). Discussion: We were able to compare the results of our study with two other French studies previously conducted on the same population of 677 patients undergoing biotherapy for chronic inflammatory rheumatism. The median BIOSECURE score in those studies was 73/100. In the study by Rat AC, published in 2017, the population was divided based on their BIOSECURE questionnaire results into three groups; they compared high and low response levels. Similarly to our study, a lower educational level and unemployment were associated with a lower rate of correct responses. The same was true for the absence of therapeutic education (TE) or distribution of brochures. Conclusions: The analysis of the BIOSECURE questionnaire in our population provides a practical message: factors associated with a low BIOSECURE score include older age, lower educational level, recent initiation of targeted therapy, and lack of participation in therapeutic education. This population could be a priority target for TE in order to ensure treatment safety for these patients. Full article
(This article belongs to the Special Issue Inflammatory Bowel Diseases in 2024 and Beyond: From Diagnosis to Treatment)
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18 pages, 1287 KiB  
Article
Are Internet Information Sources Helpful for Adult Crohn’s Disease Patients Regarding Nutritional Advice?
by Stefano Fusco, Katharina Briese, Ronald Keller, Carmen T. Schablitzki, Lisa Sinnigen, Karsten Büringer, Nisar P. Malek, Eduard F. Stange and Thomas Klag
J. Clin. Med. 2024, 13(10), 2834; https://doi.org/10.3390/jcm13102834 - 11 May 2024
Cited by 1 | Viewed by 1045
Abstract
Background: Adult patients suffering from Crohn’s disease (CD) are often dissatisfied with the information they receive from their physicians about nutrition and its impact on CD inflammation activity. Only a few publications are available about patients’ internet research on nutrition in CD. The [...] Read more.
Background: Adult patients suffering from Crohn’s disease (CD) are often dissatisfied with the information they receive from their physicians about nutrition and its impact on CD inflammation activity. Only a few publications are available about patients’ internet research on nutrition in CD. The study aim is to elucidate the internet information sources of adult CD patients regarding nutritional advice via a questionnaire. Methods: A questionnaire with 28 (general and specific) questions for outpatients at our tertiary center with CD was created and used for an analysis of their information sources about nutrition in CD. Four CD and/or nutritional medicine experts examined the 21 most relevant websites referring to nutritional advice for CD patients. Results: One hundred and fifty CD patients reported their Internet research behavior for nutritional advice and their dietary habits. Many CD patients prefer to consult the Internet instead of asking their general practitioner (GP) for nutritional recommendations. Most of the websites providing nutritional advice for CD patients are of very poor quality and cannot be recommended. We found significant correlations between (a) nutritional habits of CD patients, (b) their information sources and several demographic or CD-related factors. There is a lack of websites which provide high-quality, good nutritional advice to CD patients. Conclusions: The majority of the examined websites did not provide sufficient information according to the CD guidelines and nutritional medicine guidelines. A higher quality level of website content (e.g., on social media or on university/center websites) provided by experienced physicians is required to secure trustworthy and reliable nutritional information in CD. Full article
(This article belongs to the Special Issue Inflammatory Bowel Diseases in 2024 and Beyond: From Diagnosis to Treatment)
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