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Clinical Updates in Cardiovascular Computed Tomography (CT)

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiovascular Medicine".

Deadline for manuscript submissions: 28 February 2026 | Viewed by 275

Special Issue Editor


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Guest Editor
Department of Radiology, Fondazione G. Monasterio CNR-Regione Toscana, 56124 Pisa, Italy
Interests: cardiac imaging; blood disorders; gender differences; cardiovascular disease; women
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Special Issue Information

Dear Colleagues,

Cardiovascular disease is one of the diseases with the highest morbidity and mortality rates in the world. The rapid development of cardiovascular computed tomography (CT) technology has provided important tools for non-invasive diagnosis, risk stratification and treatment planning, and plays a key role in guiding cardiovascular interventional treatment.

This Special Issue focuses on the latest research results in the field of cardiovascular CT, covering the diagnosis of cardiovascular-related diseases, functional evaluation of coronary CTA, plaque feature analysis, artificial intelligence-assisted diagnosis, low-dose imaging technology, and emerging clinical applications (such as the evaluation of structural heart disease and cardiomyopathy). We sincerely invite you to submit original research articles and reviews (covering cutting-edge and novel clinical applications) to promote communication among doctors in radiology, cardiology and related fields, and optimize the diagnosis and treatment strategies of cardiovascular diseases.

Dr. Antonella Meloni
Guest Editor

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Keywords

  • cardiovascular CT
  • coronary CTA
  • plaque imaging
  • artificial intelligence
  • low-dose imaging
  • structural heart disease
  • cardiac imaging
  • high-risk plaque
  • atherosclerosis
  • coronary artery disease
  • valve calcification
  • thrombus detection

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Published Papers (1 paper)

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Research

13 pages, 834 KB  
Article
CT Angiography in Patients Referred for Invasive Coronary Angiography: A Single Large-Volume Tertiary Center Experience
by Migena Disha, Legate Philip, Daniel Dumitrescu, Volker Rudolph, Regine Brinkmann and Mohamed Ayoub
J. Clin. Med. 2025, 14(17), 6211; https://doi.org/10.3390/jcm14176211 - 3 Sep 2025
Viewed by 113
Abstract
Background/Objectives: Coronary artery disease (CAD) is a major cause of mortality worldwide, accounting for 7.3% of all deaths in Germany. Invasive coronary angiography (ICA) remains the gold standard for diagnosing CAD, yet coronary computed tomography angiography (CTCA) is gaining recognition as a non-invasive [...] Read more.
Background/Objectives: Coronary artery disease (CAD) is a major cause of mortality worldwide, accounting for 7.3% of all deaths in Germany. Invasive coronary angiography (ICA) remains the gold standard for diagnosing CAD, yet coronary computed tomography angiography (CTCA) is gaining recognition as a non-invasive alternative. Recent clinical trials have confirmed CTCA’s diagnostic accuracy, leading to its inclusion in the 2019 European Society of Cardiology (ESC) guidelines. Despite this, its adoption in Germany has been slow. Methods: This single-center, non-randomized study at the Heart and Diabetes Center North Rhine-Westphalia (HDZ NRW) evaluated CTCA’s safety and diagnostic performance. We included patients with low to intermediate pre-test probability (PTP) referred for cardiac catheterization between 2019 and 2022. The primary outcome was the change in the Wall Motion Score Index (ΔWMSI), with a threshold of 0.37 indicating significant mortality risk. Secondary outcomes included cardiovascular mortality, myocardial infarction, angina at follow-up, and myocardial revascularization procedures. Results: A total of 100 patients were enrolled; 30 underwent CTCA, and 70 had ICA. The mean patient age was 63 years, with 33% female. Of the 63 patients who completed follow-up (41 ICA, 22 CTCA), no significant differences in cardiovascular outcomes or mortality were observed. CTCA effectively ruled out CAD in low-risk patients, with a sensitivity of 75% and specificity of 77%. CTCA was faster (4.7 vs. 20.2 h) but had a higher radiation dose (2.3 vs. 1.5 mSv). Conclusions: CTCA is a viable, non-invasive alternative for diagnosing low- to intermediate-risk CAD patients. Further studies are needed to confirm its clinical benefits. Full article
(This article belongs to the Special Issue Clinical Updates in Cardiovascular Computed Tomography (CT))
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