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Clinical Perspectives on Acute Coronary Syndrome
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Clinical Perspectives on Acute Coronary Syndrome

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiovascular Medicine".

Deadline for manuscript submissions: 25 June 2025 | Viewed by 1132

Special Issue Editors

Dr. Marius Rus

E-Mail Website
Guest Editor
Department of Medical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, Romania
Interests: cardiology
Dr. Massimo Mancone

E-Mail Website
Guest Editor
Department of Cardiovascular, Respiratory, Nephrology, Anesthesiology and Geriatric Sciences, Sapienza University of Rome, Rome, Italy
Interests: acute coronary syndrome; percutaneous coronary intervention; myocardial infarction; TAVI; valvular heart disease; heart failure

Special Issue Information

Dear Colleagues,

It is our pleasure to invite you to submit an article for this Special Issue titled “Clinical Perspectives on Acute Coronary Syndrome”.

Approximately one-third of all deaths globally are due to ischemic heart disease, with acute coronary syndrome (ACS) being the leading cause of mortality. A thorough understanding of the causes of ACS, its pathophysiology, clinical characteristics, and potential outcomes is essential for every medical professional. Despite the tremendous progress seen in recent decades, continuous and meticulous research is required for the development of rigorous secondary prevention strategies as well as effective treatment options.

The aim of this Special Issue is to highlight the multidisciplinary approach needed to expand our clinical knowledge on ACS. Combining the expertise of cardiologists, interventional cardiologists, and cardiovascular surgeons, as well as researchers and other medical professionals, is crucial in developing adequate evidence-based treatments, creating further research lines, and delivering the best patient care. In this Special Issue, we would like to emphasize the importance of diagnosis and risk stratification tools for ACS, the role of biomarkers, as well as management and reperfusion strategies.

We encourage the submission of all types of manuscripts, including original studies, reviews, and case reports.

Dr. Marius Rus
Dr. Massimo Mancone
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • acute coronary syndrome
  • ischemic heart disease
  • multidisciplinary approach
  • interventional cardiology
  • new research lines
  • diagnosis and risk stratification
  • biomarkers
  • reperfusion strategies

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

18 pages, 2462 KiB  
Article
The Association Between Periodontal Disease and Acute Coronary Syndrome—A Clinical Analysis
by Marius Rus, Bianca Maria Negruțiu, Cristian Nicolae Sava, Georgeta Pasca, Felicia Liana Andronie-Cioara, Simina Crisan, Mircea-Ioachim Popescu, Claudia Elena Staniș and Claudia Judea Pusta
J. Clin. Med. 2025, 14(7), 2447; https://doi.org/10.3390/jcm14072447 - 3 Apr 2025
Viewed by 353
Abstract
Background: This study investigated the association between periodontal disease and acute coronary syndrome (ACS), while examining periodontitis as an independent predictor of STEMI. Materials and Methods: This study included 166 patients with ACS, of whom 103 had a history of periodontal disease. Results: [...] Read more.
Background: This study investigated the association between periodontal disease and acute coronary syndrome (ACS), while examining periodontitis as an independent predictor of STEMI. Materials and Methods: This study included 166 patients with ACS, of whom 103 had a history of periodontal disease. Results: The results showed that patients with periodontal disease were more likely to have a history of tobacco use (78.6%), diabetes (53.1%), and poor oral hygiene (72.8%). This study also found a significant association between periodontal disease and the severity of ACS (STEMI—44.7%, three-vessel/LM disease—30.1%), with patients experiencing more frequent and severe cardiovascular complications (HF—51.6%, valvulopathy and mechanical complications—22.6%, arrhythmias—19.4%). The findings support previous studies suggesting a link between periodontal disease and cardiovascular risk. This study highlights the importance of considering periodontal disease as a potential risk factor for cardiovascular disease and the need for improved access to oral health care to reduce the burden of cardiovascular events. Conclusions: Periodontal disease was identified as an independent predictor of STEMI, highlighting the need for periodontal health assessments as part of routine management in cardiovascular risk stratification. The precise mechanisms continue to be an area of active investigation. Full article
(This article belongs to the Special Issue Clinical Perspectives on Acute Coronary Syndrome)
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13 pages, 642 KiB  
Article
Risk Factors and Clinical Outcomes in Nonagenarians with Acute Coronary Syndrome: A Case-Control Study
by Zeynep Ece Demirbaş, Gönül Zeren, Fatma Can and Can Yücel Karabay
J. Clin. Med. 2025, 14(5), 1761; https://doi.org/10.3390/jcm14051761 - 6 Mar 2025
Viewed by 550
Abstract
Objective: With the growing number of individuals over the age of 90 (nonagenarians), understanding the risk factors and clinical outcomes associated with acute coronary syndrome (ACS) in this population has become increasingly important. This study aims to compare demographic, biochemical, and clinical parameters [...] Read more.
Objective: With the growing number of individuals over the age of 90 (nonagenarians), understanding the risk factors and clinical outcomes associated with acute coronary syndrome (ACS) in this population has become increasingly important. This study aims to compare demographic, biochemical, and clinical parameters between nonagenarian ACS patients and a control group of healthy individuals within the same age bracket, as well as to analyze differences within the ACS group according to myocardial infarction type and evaluate the impact of percutaneous coronary intervention (PCI) on in-hospital mortality. Methods: 104 patients aged 90–100 years diagnosed with ACS for the first time between January 2022 and January 2024 were included in this retrospectively designed case-control study. The patients were categorized into ST-elevation myocardial infarction (STEMI) and non-ST-elevation myocardial infarction (NSTEMI) groups based on their electrocardiographic findings. The control group included 113 healthy individuals within the same age range with no prior history of coronary artery disease. Data on traditional risk factors, including lipid profiles and family history, were analyzed using logistic regression models. Additionally, differences in clinical outcomes, including the length of hospital stay and mortality rates, were evaluated based on the application of PCI. Results: The ACS group exhibited significantly higher glucose, white blood cell count, and total cholesterol levels, along with lower hemoglobin and mean corpuscular volume, compared to the control group (p < 0.05). While no significant difference was found in low-density lipoprotein (LDL) levels, high-density lipoprotein (HDL) levels were significantly lower in ACS patients (p < 0.001). Family history played a more substantial role in the STEMI group compared to the NSTEMI group (p = 0.049). Additionally, STEMI patients were more likely to undergo invasive procedures, which were associated with reduced in-hospital mortality (p = 0.042). In contrast, no significant difference in mortality was observed in the NSTEMI group based on PCI status. Conclusions: This study highlights the distinct risk profiles of elderly ACS patients, emphasizing the critical role of low HDL levels and family history, particularly in STEMI cases. Furthermore, PCI was shown to reduce in-hospital mortality rates in STEMI patients, suggesting that invasive treatment approaches may be beneficial even in this vulnerable population. Personalized and multidisciplinary management strategies are essential for this vulnerable population. Further prospective research is needed to validate these findings and guide clinical decision-making for nonagenarians. Full article
(This article belongs to the Special Issue Clinical Perspectives on Acute Coronary Syndrome)
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