Clinical Update on the Diagnosis and Treatment of Heart Failure

Dear Colleagues,

Heart failure (HF) is a clinical syndrome resulting from structural and/or functional abnormalities of the heart and has a high prevalence in Western countries, significantly impacting their healthcare systems. With the aging of the population, the incidence of HF is growing, and despite significant advances in pharmacological therapy and device management, morbidity and mortality remain high, contributing to elevated healthcare costs. Etiological diagnosis and classification are crucial for understanding the underlying causes of HF and targeting treatments for each HF phenotype.

Despite recent innovations, the treatment and management of HF remain challenging and require a multidisciplinary team of physicians with expertise in clinical cardiology, imaging, intensive care, interventional cardiology, arrhythmology, and cardiac stimulation. The combination of both pharmacological and interventional treatments is essential to significantly reducing major cardiovascular events in these patients.

Currently, several novel and existing technologies are available for HF treatment, allowing multiple therapeutic strategies. Innovations in pharmacology and percutaneous technologies include soluble guanylate cyclase stimulators, selective cardiac myosin activators, transcatheter treatment of valvular disease, atrial flow regulator devices, left ventricle remodeling systems, cardiac resynchronization therapy, and contractility modulation.

This Special Issue aims to provide a focused update on new clinical data and perspectives in the field of heart failure, encompassing diagnosis, management, innovative treatments, and novel technologies. It will serve as a forum for high-quality original research and review articles, showcasing the latest clinical advances and future perspectives in HF management.

Dr. Giulia Nardi
Dr. Alessio Mattesini
Guest Editors

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• ejection fraction
• acute heart failure
• multidisciplinary management
• right heart failure
• left ventricle remodeling systems
• HF percutaneous treatment; pharmacotherapy
• HF prevention
• cardiomyopathies