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New Technologies and Translational Approach for an Early Diagnosis of...
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New Technologies and Translational Approach for an Early Diagnosis of Bipolar Spectrum and Hyperactive and Novelty Seeking Profiles

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Mental Health".

Deadline for manuscript submissions: 25 June 2025 | Viewed by 784

Special Issue Editors

Dr. Massimo Tusconi

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Guest Editor
Section of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, 09042 Cagliari, Italy
Interests: psychiatry; statistics; bipolar disorders; mood; biomarkers
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Serdar Dursun

E-Mail Website
Guest Editor
Psychiatry & Neuroscience, Department of Psychiatry (Neurochemical Research Unit) and Neuroscience & Mental Health Institute, University of Alberta, Edmonton, AB T6G 2G3, Canada
Interests: psychopharmacology; molecular neuroscience & psychiatry; schizophrenia; translational neuroscience and psychiatry
Special Issues, Collections and Topics in MDPI journals
Dr. Germano Orru

E-Mail Website
Guest Editor
Molecular Biology Service (AOU-Cagliari), Department of Surgical Sciences, University of Cagliari, Cagliari, Italy
Interests: molecular biology; genetics of mood disorders; laboratory medicine; metabolomics, oral microbiology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The expectation of defining a precise genetic marker that can identify bipolar disorder (BD) has been dashed by current research, as the psycho-pathology of severe mental illnesses, including BD, includes complex traits sustained by the coalescence of many genes, each of which exerts small influences on observable phenomena, thus hindering Mendelian randomization studies and the identification of reliable biomarkers of lithium response.

A broader view of the polygenic hypothesis has prompted current studies to look for conditions, possibly related to specific genetic characteristics, that might, in interaction with the environment, put BD at risk in interaction with the environment.

This Special Issue aims to gather contributions in the area of research we have thus defined. In particular, because of the preventive importance of being able to identify conditions at risk of developing bipolar disorder, this contribution aims to gather information on new genetic, laboratory, and more generally diagnostic techniques that may make it possible to identify the risk area, described by the above-mentioned new line of research, of future bipolar disorder.

Contributors are welcome to use the formats of an original research article, brief research report, systematic review, review, mini-review, policy and practice review, hypothesis and theory, perspective, case report, community case study, general commentary, or opinion.

Dr. Massimo Tusconi
Prof. Dr. Serdar Dursun
Dr. Germano Orru
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • psychiatry
  • mental health
  • bipolar disorders
  • mood
  • biomarkers
  • new technology
  • BD

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Published Papers (1 paper)

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Research

8 pages, 367 KiB  
Article
Predictors of Transition from Child and Adolescent Bipolar Not Otherwise Specified to Bipolar I Disorder, a Longitudinal 3.9-Year Study
by María Ribeiro-Fernández, Azucena Díez-Suárez, Kiki D. Chang and Cesar A. Soutullo
J. Clin. Med. 2024, 13(19), 5656; https://doi.org/10.3390/jcm13195656 - 24 Sep 2024
Viewed by 635
Abstract
Background: Children and adolescents with subthreshold manic symptoms not meeting full DSM criteria for bipolar I or II disorder (BP-I or BP-II) are classified as unspecified bipolar disorder (formerly bipolar not otherwise specified: BP-NOS). Factors associated with transition from BP-II or NOS to [...] Read more.
Background: Children and adolescents with subthreshold manic symptoms not meeting full DSM criteria for bipolar I or II disorder (BP-I or BP-II) are classified as unspecified bipolar disorder (formerly bipolar not otherwise specified: BP-NOS). Factors associated with transition from BP-II or NOS to BP-I may predict the progression of the disorder. Our objective is to analyze factors associated with transition to BP-I in a Spanish sample of youth with BP-NOS or BP-II. Methods: We included all youth diagnosed with BP before 18 years of age presenting to our clinic (October 1999–December 2014). We assessed clinical factors that may predict transition to BP I with a logistic regression and a multivariable model for data analysis. Results: A total of 72 patients with BP, mean (SD) age 14.5 (10.5–16.0) years, were followed for a median period of 3.9 years. In total, 95.8% of patients retained the BP diagnosis, but they changed type. Baseline BP-I % was 37.5%, and 62.5% at endpoint. BP-NOS decreased from baseline 54.2% to 25% at endpoint. The % of BP-II was 8.3% in both time points, but they were not the same individual patients, as some transitioned from BP-II to BP-I and some BP-NOS changed to BP-II. BP-NOS was stable in 46.1% of patients, but 38.5% transitioned to BP-I over time. Psychotic symptoms during prior depressive episodes (MDD) increased the risk of transition to BP-I by 11-fold. Each individual symptom of mania increased the risk of transition to BP-I by 1.41. Conclusions: BP-NOS was stable in 46.1% of patients, but 38.5% transitioned to BP-I over time. Psychotic symptoms during prior MDD episodes increased the risk of transition from BP-NOS to BP-I. Full article
(This article belongs to the Special Issue New Technologies and Translational Approach for an Early Diagnosis of Bipolar Spectrum and Hyperactive and Novelty Seeking Profiles)
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