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Advances in Parkinsonian Disorders
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Advances in Parkinsonian Disorders

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Clinical Neurology".

Deadline for manuscript submissions: closed (25 May 2023) | Viewed by 5483

Special Issue Editor

Dr. Gilad Yahalom

E-Mail Website
Guest Editor
Department of Neurology and the Movement Disorders Unit, Shaare Zedek Medical Center, Jerusalem, Israel
Interests: Parkinson's disease; genetics; botulinum toxin; gait analysis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's disease. As of yet, due to available symptomatic treatment, an adequate level of quality of life may be maintained until the very advanced stages of the disorder. Despite the advancements in knowledge of the pathological processes associated with the degeneration leading to PD, there are some challenging aspects without adequate relief, such as dementia, levodopa-resistant freezing of gait, and postural instability.

This Special Issue of the Journal of Clinical Medicine will cover the following important items:

  • Gait assessment of PD, focusing on freezing of gait.
  • Physical activity for PD.
  • Non-dopaminergic therapy for PD.
  • Non-motor advances in PD, with a preference for cognitive disturbances.
  • Microbiome study.
  • Palliative care for PD.

Dr. Gilad Yahalom
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Parkinson's disease
  • gait analysis
  • physical activity
  • non-dopaminergic treatment
  • cognitive
  • microbiome
  • palliative care

Published Papers (3 papers)

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Editorial

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7 pages, 234 KiB  
Editorial
Tardive Syndrome Is a Mysterious Phenomenon with Different Clinical Manifestations—Review
by Samih Badarny, Rima Nassar and Yazid Badarny
J. Clin. Med. 2023, 12(4), 1498; https://doi.org/10.3390/jcm12041498 - 14 Feb 2023
Cited by 1 | Viewed by 1945
Abstract
Tardive syndrome (TS) refers to persistent hyperkinetic, hypokinetic, and sensory complaints appearing after chronic neuroleptics and other dopamine receptor-blocking agents (DRBAs). It is defined as involuntary movements, often rhythmic, choreiform, or athetoid, involving the tongue, face, extremities, and sensory urges such as akathisia [...] Read more.
Tardive syndrome (TS) refers to persistent hyperkinetic, hypokinetic, and sensory complaints appearing after chronic neuroleptics and other dopamine receptor-blocking agents (DRBAs). It is defined as involuntary movements, often rhythmic, choreiform, or athetoid, involving the tongue, face, extremities, and sensory urges such as akathisia and lasts for a few weeks. TS develops in association with neuroleptic medication usage for a few months at least. There is usually a delay between the initiation of the causative drug and the onset of abnormal movements. However, it was soon noted that TS can also develop early, even days or weeks after DRBAs begin. However, the longer the exposure, the greater the risk of developing TS. Tardive dyskinesia, dystonia, akathisia, tremor, and parkinsonism are frequent phenomenologies of this syndrome. Full article
(This article belongs to the Special Issue Advances in Parkinsonian Disorders)

Research

Jump to: Editorial

14 pages, 829 KiB  
Article
Association between Cognitive Impairment and Freezing of Gait in Patients with Parkinson’s Disease
by Yifei Gan, Hutao Xie, Guofan Qin, Delong Wu, Ming Shan, Tianqi Hu, Zixiao Yin, Qi An, Ruoyu Ma, Shu Wang, Quan Zhang, Guanyu Zhu and Jianguo Zhang
J. Clin. Med. 2023, 12(8), 2799; https://doi.org/10.3390/jcm12082799 - 10 Apr 2023
Cited by 4 | Viewed by 1765
Abstract
Background: Freezing of gait (FOG) is a common disabling symptom in Parkinson’s disease (PD). Cognitive impairment may contribute to FOG. Nevertheless, their correlations remain controversial. We aimed to investigate cognitive differences between PD patients with and without FOG (nFOG), explore correlations between FOG [...] Read more.
Background: Freezing of gait (FOG) is a common disabling symptom in Parkinson’s disease (PD). Cognitive impairment may contribute to FOG. Nevertheless, their correlations remain controversial. We aimed to investigate cognitive differences between PD patients with and without FOG (nFOG), explore correlations between FOG severity and cognitive performance and assess cognitive heterogeneity within the FOG patients. Methods: Seventy-four PD patients (41 FOG, 33 nFOG) and 32 healthy controls (HCs) were included. Comprehensive neuropsychological assessments testing cognitive domains of global cognition, executive function/attention, working memory, and visuospatial function were performed. Cognitive performance was compared between groups using independent t-test and ANCOVA adjusting for age, sex, education, disease duration and motor symptoms. The k-means cluster analysis was used to explore cognitive heterogeneity within the FOG group. Correlation between FOG severity and cognition were analyzed using partial correlations. Results: FOG patients showed significantly poorer performance in global cognition (MoCA, p < 0.001), frontal lobe function (FAB, p = 0.015), attention and working memory (SDMT, p < 0.001) and executive function (SIE, p = 0.038) than nFOG patients. The FOG group was divided into two clusters using the cluster analysis, of which cluster 1 exhibited worse cognition, and with older age, lower improvement rate, higher FOGQ3 score, and higher proportion of levodopa-unresponsive FOG than cluster 2. Further, in the FOG group, cognition was significantly correlated with FOG severity in MoCA (r = −0.382, p = 0.021), Stroop-C (r = 0.362, p = 0.030) and SIE (r = 0.369, p = 0.027). Conclusions: This study demonstrated that the cognitive impairments of FOG were mainly reflected by global cognition, frontal lobe function, executive function, attention and working memory. There may be heterogeneity in the cognitive impairment of FOG patients. Additionally, executive function was significantly correlated with FOG severity. Full article
(This article belongs to the Special Issue Advances in Parkinsonian Disorders)
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10 pages, 597 KiB  
Article
Reproductive Lifespan and Motor Progression of Parkinson’s Disease
by Ruwei Ou, Qianqian Wei, Yanbing Hou, Lingyu Zhang, Kuncheng Liu, Junyu Lin, Tianmi Yang, Jing Yang, Zheng Jiang, Wei Song, Bei Cao and Huifang Shang
J. Clin. Med. 2022, 11(20), 6163; https://doi.org/10.3390/jcm11206163 - 19 Oct 2022
Cited by 1 | Viewed by 1463
Abstract
Objectives: Estrogen not only plays a key role in the decreased risk of Parkinson’s disease (PD) but also influences its severity. We aimed to explore the effect of the reproductive lifespan on the motor progression of PD female patients in a large prospective [...] Read more.
Objectives: Estrogen not only plays a key role in the decreased risk of Parkinson’s disease (PD) but also influences its severity. We aimed to explore the effect of the reproductive lifespan on the motor progression of PD female patients in a large prospective cohort study. Methods: A competing risk analysis with a Fine and Gray model on 491 female and 609 male patients with PD was conducted. We regarded the chance of faster motor progression (as measured by the Unified Parkinson’s Disease Rating Scale (UPDRS) III increasing by ≥16 points during follow-up) and the chance of death as competing risks. The reproductive lifespan was regarded as the variable of interest, while faster motor progression was set as the primary outcome. Results: In the multivariable competing risk analysis, the male sex was not significantly associated with faster motor progression (subdistribution hazard ratio (SHR) 0.888, 95% CI 0.652–1.209, p = 0.450), while a shorter reproductive lifespan was associated with faster motor progression in women (SHR 0.964, 95% CI 0.936–0.994, p = 0.019). Sensitivity analysis indicated that a shorter reproductive lifespan was also significantly associated with faster motor progression in the 48 female patients who reported menopause after the onset of PD (SHR 0.156, 95% CI 0.045–0.542, p = 0.003). A linear mixed model also revealed the significant main effects of a short reproductive lifespan on the higher UPDRS III score in PD female patients at the last visit (p = 0.026). Conclusions: Our study indicates that a short reproductive lifespan contributes to faster motor progression in PD female patients, which has important implications for understanding the role of endogenous estrogen exposure in female PD and is beneficial to select appropriate patients in clinical trials. Full article
(This article belongs to the Special Issue Advances in Parkinsonian Disorders)
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