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Clinical Advances in Urologic Oncology
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Clinical Advances in Urologic Oncology

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Nephrology & Urology".

Deadline for manuscript submissions: 25 July 2024 | Viewed by 1258

Special Issue Editor

Dr. Saum Ghodoussipour

E-Mail Website
Guest Editor
Section of Urologic Oncology, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA
Interests: urologic oncology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The world of urologic oncology is rapidly evolving. Within the realm of bladder, prostate, kidney, testis and penile cancers, new treatment paradigms, medications and surgical modifications are evolving in parallel with progressive research on these topics. For example, in bladder cancer, novel intravesical and targeted therapies are gaining traction. For prostate cancer, advanced imaging and less invasive focal therapy has been increasingly utilized. These examples just begin to scratch the surface of the recent developments in our field. For this Special Issue, we encourage authors to submit papers on the recent clinical updates on urologic cancer of their interest.

Dr. Saum Ghodoussipour
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bladder cancer
  • kidney cancer
  • prostate cancer
  • testis cancer
  • penile cancer
  • minimally invasive
  • cancer treatment

Published Papers (2 papers)

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Research

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11 pages, 255 KiB  
Article
Predictive Factors for Major Complications and Urological Cancer Diagnosis in Older Adults (≥80 Years) Admitted to the Emergency Department for Hematuria
by Mauro Ragonese, Daniele Fettucciari, Luigi Carbone, Filippo Gavi, Marco Montesi, Eros Scarciglia, Pierluigi Russo, Domenico Maria Sanesi, Filippo Marino, Nazario Foschi, Francesco Pinto, Francesco Franceschi, Marco Racioppi, Emilio Sacco and Marcello Covino
J. Clin. Med. 2024, 13(10), 2874; https://doi.org/10.3390/jcm13102874 - 13 May 2024
Viewed by 623
Abstract
Background: Gross Hematuria is a relevant cause of admission to the emergency department in the general population and particularly in older adults (≥80 years). This specific urological symptom is often underestimated and usually associated with benign conditions such as urinary infections or [...] Read more.
Background: Gross Hematuria is a relevant cause of admission to the emergency department in the general population and particularly in older adults (≥80 years). This specific urological symptom is often underestimated and usually associated with benign conditions such as urinary infections or poor hydration. Nevertheless, hematuria could lead to severe acute complications or be the first symptom of urological cancers. Methods: We retrospectively analyzed clinical data from 1169 patients aged ≥80 years consecutively admitted to the emergency department for hematuria. The primary endpoint of the study was to identify risk factors for major complications, and the secondary endpoint was to analyze risk factors for urological cancer diagnosis. The median age was 85 years (IQR 82–88 years), and 908 (77%) were males. Among them, 449 (38.4%) had a past medical history of urological neoplasm (kidney, ureter, bladder, prostate, or urethral cancer). Results: Overall, 87 patients (7.4%) had major complications (patient death, septic shock, and admission to the intensive care unit). Worse vital signs at admission, fever, and confusion (p < 0.001, OR 18.0 IC 95% [5.5–58.7]; p = 0.015, OR 2.0 IC 95% [1.1–3.5]; p = <0.001, OR 4.2 IC 95% [1.9–3.5], respectively), as well as lower hemoglobin values and higher Charlson comorbidity index (p < 0.001, OR 0.8 IC 95% [0.7–0.9]), p = 0.002, OR = 1.2 [1.1–1.3]) were independent predictive factors for major complications. The multivariate analysis identified as risk factors for diagnosis of urological cancer older age, male sex and higher comorbidity (OR 1.05 IC95% [1–1.09]; OR 2.19 IC95% [1.42–3.39] and OR 1.11 IC95% [1.2–1.2], respectively); interestingly the presence of indwelling vesical catheter (IVC) (OR 0.44 IC95% [0.24–0.82]) resulted as an independent factor for absence of urological cancers. Conclusions: Hematuria is a frequent symptom in older adults admitted to the emergency department. While this is often associated with benign conditions, there are some risk factors for major complications and for urological cancer that must be taken into account to identify the patients who need further evaluation or prompt hospital admission. Full article
(This article belongs to the Special Issue Clinical Advances in Urologic Oncology)

Review

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18 pages, 1017 KiB  
Review
The Cellular Stress and Cutaneous Manifestations in Renal Cell Carcinomas—A Narrative Review
by Corina Daniela Ene, Ilinca Nicolae, Mircea Tampa, Simona Roxana Georgescu, Cosmin Ene, Clara Matei, Iulia Maria Teodora Leulescu, Cristina Iulia Mitran, Madalina Irina Mitran and Cristina Capusa
J. Clin. Med. 2024, 13(13), 3640; https://doi.org/10.3390/jcm13133640 - 21 Jun 2024
Viewed by 377
Abstract
The carcinomas originating from the renal cortex are the most aggressive renal malignancies, with a high tendency for metastasis. Understanding the incidence of cutaneous manifestations caused by renal carcinomas is a challenge. In the first part, this article summarizes a series of factors [...] Read more.
The carcinomas originating from the renal cortex are the most aggressive renal malignancies, with a high tendency for metastasis. Understanding the incidence of cutaneous manifestations caused by renal carcinomas is a challenge. In the first part, this article summarizes a series of factors that promote oncogenesis, invasiveness, and the ability of renal cell carcinoma (RCC) to develop secondary cutaneous manifestations. It is postulated that the cellular stress response is one of the leading causes of developing dermatological events induced by cancers located at distant sites. Furthermore, the paper provides an overview of cutaneous complications associated with renal cancer, categorized as malignant manifestations (metastases, synchronous or metachronous cutaneous malignancies associated with renal cancer), non-malignant indirect cutaneous manifestations associated with renal cancer, and treatment consequences. The data presented in this article suggest that recognizing certain cutaneous disorders could assist the physician in the early identification of renal neoplasms and could lead to a better prognosis. Full article
(This article belongs to the Special Issue Clinical Advances in Urologic Oncology)
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