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Stroke Care: From Acute Interventions to Long-Term Recovery

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Clinical Neurology".

Deadline for manuscript submissions: 20 June 2026 | Viewed by 1321

Special Issue Editors


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Guest Editor
2nd Department of Neurology, School of Medicine, National and Kapodistrian University of Athens, “Attikon” General University Hospital, 12462 Athens, Greece
Interests: stroke; cerebrovascular diseases; acute repercussion therapies; intracerebral hemoorhage; rehabilitation

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Guest Editor
2nd Department of Neurology, School of Medicine, National and Kapodistrian University of Athens, “Attikon” General University Hospital, 12462 Athens, Greece
Interests: stroke; cerebrovascular diseases; acute reperfusion therapies; intracerebral hemoorhage; rehabilitation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The spectrum of acute stroke, whether ischemic or hemorrhagic, extends from rapid emergency management to long-term rehabilitation. In the acute phase, timely recognition and intervention—such as thrombolysis or thrombectomy for ischemic stroke, and surgical or medical management for hemorrhagic stroke—are critical to minimize brain injury and stabilize the patient. Determining the underlying etiology is essential: ischemic strokes may arise from cardioembolism, large-artery atherosclerosis, or small-vessel disease, while intracerebral hemorrhage may result from chronic hypertension, cerebral amyloid angiopathy, vascular malformations, or anticoagulant use. Identifying these causes informs secondary prevention strategies, including antithrombotic therapy, blood pressure control, and lifestyle modification. Once stabilized, patients benefit from early, multidisciplinary rehabilitation—physiotherapy, occupational and speech therapy, and psychosocial support—to optimize recovery, independence, and long-term quality of life. The aim of this Special Issue is to provide a comprehensive overview of the continuum of stroke care, spanning from acute management of ischemic and hemorrhagic stroke to long-term rehabilitation.

Dr. Aikaterini Theodorou
Dr. Georgios Tsivgoulis
Guest Editors

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Keywords

  • cerebrovascular diseases
  • acute ischemic stroke
  • intravenous thrombolysis
  • endovascular thrombectomy
  • intracerebral hemorrhage
  • etiology
  • cerebral amyloid angiopathy
  • stroke rehabilitation

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Published Papers (1 paper)

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Research

10 pages, 855 KB  
Article
Aesthetic Rehabilitation of Patients with Central and Peripheral Facial Palsy with Injectables (BNT-A, HA-Fillers and CaHa)
by Athanasios Tsivgoulis, Eleftherios Stefas, Georgios Galatas, Georgia Papagiannopoulou, Stella Fanouraki, Maria-Ioanna Stefanou, Pinelopi Vlotinou, Christina Zompola, Georgios Tsivgoulis and Aikaterini Theodorou
J. Clin. Med. 2026, 15(1), 388; https://doi.org/10.3390/jcm15010388 - 5 Jan 2026
Viewed by 1037
Abstract
Background: Facial palsy constitutes a profoundly disabling condition, often leading to marked functional deficits and a decline in facial appearance, which substantially reduces the patient’s quality of life. A combined therapy of botulinum toxin (BoNTA), hyaluronic acid (HA) and calcium hydroxylapatite (CaHA) appears [...] Read more.
Background: Facial palsy constitutes a profoundly disabling condition, often leading to marked functional deficits and a decline in facial appearance, which substantially reduces the patient’s quality of life. A combined therapy of botulinum toxin (BoNTA), hyaluronic acid (HA) and calcium hydroxylapatite (CaHA) appears promising in the pharmacological approach of these patients. Methods: We reported our single center experience of patients with facial palsy, either of central or peripheral etiology who were treated with the combination of BoNTA, HA and CaHA, during a 6-month period (January 2025–June 2025). Results: Eight consecutive adult patients [mean age: 49.50 ± 7.95 years, 6 (75%) female] with facial palsy, either of central (4 patients) or peripheral (4 patients) etiology, received the combination of BoNTA, HA and CaHA. No serious adverse reactions were documented. Localized bruising and swelling at injection sites resolved without requiring any additional intervention. Facial Disability Index (FDI) was assessed both prior to and following treatment. The functional subscale increased from 65.63 ± 16.13 to 80.63 ± 10.50 (improvement rate = 24.4%, p-value = 0.002), while the psychosocial subscale increased from 63.00 ± 17.34 to 74.50 ± 10.89 (improvement rate = 18.3%, p-value = 0.004). Consequently, the total FDI score improved from 128.63 ± 28.92 to 155.13 ± 17.96 (overall improvement = 20.6%, p-value = 0.001). Conclusions: The present case series underscores the potential therapeutic role of CaHA as an adjunct to BoNTA and HA injections in patients with central or peripheral facial palsy. Full article
(This article belongs to the Special Issue Stroke Care: From Acute Interventions to Long-Term Recovery)
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