General Anesthesia: Recent Developments and Emerging Trends
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Anesthesiology".
Deadline for manuscript submissions: 15 April 2025 | Viewed by 50
Special Issue Editor
Interests: anesthesia
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Research and development are an integral part of anesthesiology practice. In recent years, areas such as drug development, memory and awareness, closed-loop systems, and brain monitoring have seen noticeable advances. While sugammadex has nearly eliminated the risk of inadequate reversal and residual paralysis, the newer benzodiazepine remimazolam might assist us in performing procedures such as colonoscopy without the need for propofol. Tegileridine and oliceridine are new classes of opioids that selectively bind and preferentially activate the G-protein signaling pathway rather than β-arrestin 2, thereby limiting the unwanted opioid side effects such as respiratory depression, hyperalgesia, PONV, and constipation. Computer-aided drug design and development is another exciting area that might herald the development of drugs that could target specific ligands or undergo organ-independent metabolism with no toxic metabolites. Though research into depth of anesthesia and awareness is continuing, recent evidence indicates that, after all, deep general anesthesia is not harmful in terms of risk for postoperative delirium.
Closed-loop administration of intravenous anesthetics and closed-circuit anesthesia are additional enthusing areas. They are shown to surpass anesthesia providers in terms of titration to a defined end point that may be variable.
While the study of the mechanism of action of general anesthetic agents is an ongoing area, their reversal is even more intriguing. The benefits of such an invention are enormous and include a quicker wake-up time and a reduction in postoperative complications.
In this Special Issue, Journal of Clinical Medicine (JCM) would like to welcome researchers from around the world to submit research- and discussion-related manuscripts encompassing the above areas.
Prof. Dr. Basavana Goudra
Guest Editor
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Keywords
- general anesthesia
- recent advances
- drug development
- memory and awareness
- brain monitoring
- sugammadex
- tegileridine
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