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Current Challenges in the Management of Vitreoretinal Conditions: 2nd Edition
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Current Challenges in the Management of Vitreoretinal Conditions: 2nd Edition

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Ophthalmology".

Deadline for manuscript submissions: closed (30 June 2025) | Viewed by 5540

Special Issue Editor

Dr. Georgios Panos

E-Mail Website
Guest Editor
1. Department of Ophthalmology, School of Medicine, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece
2. Division of Ophthalmology and Visual Sciences, School of Medicine, University of Nottingham, Nottingham NG7 2UH, UK
Interests: ophthalmology; retina; vitreoretinal surgery; medical retina; molecular biology in ophthalmology; ocular pharmacology; ophthalmic surgery; biomarkers
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In the ever-evolving landscape of Ophthalmology, the pursuit of excellence in understanding and managing eye diseases continues to push the boundaries of medical and surgical retina. Building upon the foundation laid by the first volume, we are proud to announce the call for submissions for the 2nd Edition of our Special Issue titled "Current Challenges in the Management of Vitreoretinal Conditions”(https://www.mdpi.com/journal/jcm/special_issues/vitreoretinal_conditions).

This Special Issue will delve deeper into the latest advancements and explore emerging challenges in the treatment and surgical intervention of vitreoretinal diseases. We aim to encapsulate the cutting-edge developments and innovative research that have emerged since our last volume, focusing on the enhancement of patient care and treatment outcomes for conditions such as age-related macular degeneration, diabetic retinopathy, retinal detachment, and more.

We invite high-quality original research studies, both clinical and experimental, that contribute to our growing understanding of these complex conditions. Comprehensive review articles that synthesize recent advancements, propose new treatment paradigms, or evaluate the long-term outcomes of novel therapies are also welcome. Additionally, we continue to recognize the impact of global health challenges, such as the COVID-19 pandemic, on the management of vitreoretinal diseases and encourage submissions that address these topics.

Potential topics include, but are not limited to, the following:

  • Innovations in the medical and surgical management of vitreoretinal diseases;
  • Advances in anti-VEGF therapies and the development of new drug delivery systems;
  • Novel diagnostic and imaging techniques in the assessment of vitreoretinal conditions;
  • The role of genetics and personalized medicine in treating retinal and vitreoretinal disorders;
  • The influence of telemedicine and digital health technologies on patient care and management;
  • Comprehensive strategies for managing the complex cases of retinal detachment, macular holes, and epiretinal membranes;
  • The evaluations of the socio-economic impacts on the accessibility and quality of vitreoretinal care;
  • Insights into the management of uveitis and ocular inflammations in the modern era.

We believe that this 2nd Edition will be an essential addition to the collective knowledge in the field, offering a platform for sharing groundbreaking research and fostering discussions that will shape the future of vitreoretinal medicine.

We look forward to receiving your contributions.

Dr. Georgios D. Panos
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • retina
  • anti-VEGF
  • implants
  • macular degeneration
  • diabetic retinopathy
  • vein occlusions
  • retinal detachments
  • vit-reoretinal surgery
  • COVID-19 impact

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Related Special Issue

Published Papers (2 papers)

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Research

11 pages, 3816 KB  
Article
Mechanisms of Gas-Induced Posterior Vitreous Detachment: A Look Behind the Bubble Using Optical Coherence Tomography in Prone Position
by Julian Elias Klaas, Jakob Siedlecki, Benedikt Schworm, Nikolaus Feucht, Mathias Maier and Siegfried G. Priglinger
J. Clin. Med. 2026, 15(4), 1350; https://doi.org/10.3390/jcm15041350 - 9 Feb 2026
Viewed by 396
Abstract
Objectives: We aimed to visualize the interaction of intravitreal gas with the adjacent vitreomacular interface by using prone position (PP) SD-OCT and suggest possible mechanisms of action behind gas-induced posterior vitreous detachment (PVD) in pneumatic vitreolysis (PV). Methods: This was a descriptive–interpretative morphological [...] Read more.
Objectives: We aimed to visualize the interaction of intravitreal gas with the adjacent vitreomacular interface by using prone position (PP) SD-OCT and suggest possible mechanisms of action behind gas-induced posterior vitreous detachment (PVD) in pneumatic vitreolysis (PV). Methods: This was a descriptive–interpretative morphological study. Spectral domain OCT imaging in PP was carried out using a flexible scanning module (SD-OCT-Flex, Heidelberg Engineering) originally designed for bedside imaging. Routine imaging in sitting position was carried out using a regular SD-OCT-device (Heidelberg Engineering). Patients with symptomatic vitreomacular traction (VMT) scheduled for PV with perfluoropropane (C3F8, 0.3 mL) received both sitting and PP imaging immediately before and at regular follow-up visits during the first 3 post-procedural weeks, beginning 3 h after PV. Imaging was reviewed for positional changes of the gas bubble, posterior hyaloid membrane (PHM), VMT configuration, and retrohyaloidal fluid (RHF). Results: Three consecutive patients with VMT were included (age: 79, 80, 82 years). Before the procedure, no positional alterations were detected. After the intravitreal injection of gas, PP allowed for the precise discrimination of the PHM and the posterior border of the gas bubble. In contrast to regular SD-OCT in sitting position, PP imaging showed a flattened VMT by the gas bubble with consecutive displacement of RHF from the macular region to the midperiphery. Conclusions: This exploratory study describes PP imaging as a tool for the assessment of the morphologic dynamics between the posterior hyaloid membrane, retina, and gas bubble in pneumatic vitreolysis. PP in pneumatic vitreolysis causes the gas bubble to flatten the VMT and to push retrohyaloidal fluid to the midperiphery, possibly allowing for the release of persistent vitreoretinal adhesions and consequent PVD induction. Full article
(This article belongs to the Special Issue Current Challenges in the Management of Vitreoretinal Conditions: 2nd Edition)
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8 pages, 195 KB  
Article
Symptomatic Vitreous Opacities: Exploring the Mismatch between Clinical Observation of Vitreous Alterations and Self-Reported Symptoms
by Giulio Bamonte, Clemente Maria Iodice, Rodolfo Mastropasqua, Elon H. C. Van Dijk, Andrea Appeltans, Maria Vittoria Cicinelli, Matteo Menean, Marcel Ten Tusscher, Stuart W. Harmer, Paola Marolo, Enrico Borrelli, Michele Reibaldi, Georgios D. Panos and Lorenzo Motta
J. Clin. Med. 2024, 13(20), 6052; https://doi.org/10.3390/jcm13206052 - 11 Oct 2024
Cited by 3 | Viewed by 4149
Abstract
Objectives: To assess the mismatch between the clinical observation of vitreous alterations and self-reported symptoms in young patients complaining of symptomatic vitreous opacities (SVO). Methods: The ophthalmic medical records of young patients presenting primarily with SVO were retrospectively evaluated. Symptoms severity was assessed [...] Read more.
Objectives: To assess the mismatch between the clinical observation of vitreous alterations and self-reported symptoms in young patients complaining of symptomatic vitreous opacities (SVO). Methods: The ophthalmic medical records of young patients presenting primarily with SVO were retrospectively evaluated. Symptoms severity was assessed using a questionnaire. The status of the vitreous body was examined with indirect ophthalmoscopy at the slit-lamp and classified according to an ad hoc severity scale. Results: Sixty eyes of thirty otherwise healthy patients (median age: 32.5 (IQR: 29.0–37.0) years old) complaining of SVO (median duration: 38 months; interquartile range: 18–84 months) were enrolled. SVO was rated as severe by 50% of participants, affecting all the activities explored in the questionnaire. Twenty-three patients (76.6%) reported SVO-related depression and/or anxiety, for which eleven patients (36.6%) were or had been using medication. Fifty-eight eyes (96.6%) showed no evidence of (or minimal) vitreous opacity, while two eyes (3.3%) were found to have significant vitreous opacity. No significant inter-gender differences (p > 0.05) and no significant differences (p > 0.05) were found between the severity of vitreous opacity and patients’ reported symptoms nor with their psychological status and medication use. Conclusions: Severe discomfort related to the perception of vitreous floaters exists in young patients whose vitreous gel examination is unremarkable or shows only minor alterations. We believe this discrepancy can be explained by optical anisotropy; significant forward-scattering of light, which results in floater symptoms; and reduced back reflection, which limits the clinical observation. Full article
(This article belongs to the Special Issue Current Challenges in the Management of Vitreoretinal Conditions: 2nd Edition)
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