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Personalized Medicine: Future Perspectives on Personalized Oral and Maxillofacial Surgery

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Dentistry, Oral Surgery and Oral Medicine".

Deadline for manuscript submissions: 15 July 2026 | Viewed by 1561

Special Issue Editors


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Guest Editor
Regina Maria Private Healthcare Network, Bucharest, Romania
Interests: head and neck surgery; head and neck oncology; head and neck reconstructions; personalized medicine; artificial intelligence; head and neck trauma; integrative medicine
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Oral and Maxillofacial Surgery and Implantology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania
Interests: head and neck surgery; head and neck oncology; head and neck reconstructions

E-Mail Website
Guest Editor
Department of Maxillofacial Surgery and Radiology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania
Interests: head and neck radiology; personalized medicine; artificial intelligence

Special Issue Information

Dear Colleagues,

Modern medicine encompasses technologies that not only enhance life expectancy but also improve overall quality of life. Additionally, it is now well-established that oral health and general health are interlinked in a bidirectional manner. As a result, maintaining good oral health and functionality positively impacts the overall well-being of the body. Furthermore, treatments involving the oral cavity must be tailored to meet the individual needs and characteristics of each patient.

Advances in diagnostic tools are being developed to facilitate the rapid detection of oral diseases, including cancer, through minimally invasive techniques such as liquid biopsy using saliva. Saliva serves as a mirror of the entire body, reflecting various biomarkers of disease. Alongside this, personalized treatment approaches are emerging to minimize surgical morbidity. For example, in head and neck trauma, minimally invasive methods are being used with custom-designed plates generated by specialized software enhanced by artificial intelligence.

The goal of this Special Issue is to provide a comprehensive foundation for these innovative personalized medicine approaches, which not only improve patient quality of life but also enable early disease detection and highlight the connection between oral health and overall systemic health.

Thus, we invite researchers to share their contributions with the scientific community through original research articles and reviews focusing on advancements in diagnostic tools, new treatment methods, and the relationship between oral diseases and general health conditions.

Dr. Cosmin Ioan Faur
Dr. Rareș Calin Roman
Prof. Dr. Mihaela Carmen Hedeşiu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • head and neck surgery
  • head and neck oncology
  • head and neck reconstructions
  • personalized medicine
  • artificial intelligence
  • head and neck trauma
  • integrative medicine

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Published Papers (1 paper)

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19 pages, 1181 KB  
Systematic Review
Nigella Sativa and Thymoquinone for Prevention or Mitigation of Acquired Sensorineural Hearing Loss: A Systematic Review
by Hunor Levente Horvath, Violeta Necula, Maximilian George Dindelegan, Cristina Maria Blebea, Victor Esanu and Alma Aurelia Maniu
J. Clin. Med. 2025, 14(23), 8433; https://doi.org/10.3390/jcm14238433 - 27 Nov 2025
Viewed by 1001
Abstract
Background/Objectives: Acquired sensorineural hearing loss (SNHL) can result from a wide range of insults, including ototoxic drugs, Meniere’s disease, noise-induced ototoxicity, and aging. The underlying pathophysiological mechanism arises through damage to the inner ear via oxidative stress and inflammation. Recent research suggests that [...] Read more.
Background/Objectives: Acquired sensorineural hearing loss (SNHL) can result from a wide range of insults, including ototoxic drugs, Meniere’s disease, noise-induced ototoxicity, and aging. The underlying pathophysiological mechanism arises through damage to the inner ear via oxidative stress and inflammation. Recent research suggests that natural antioxidants are promising solutions to prevent SNHL. Nigella sativa (NS), through its active compound thymoquinone (TQ), is a potent antioxidant that has shown promising results. The aim of this systematic review is to examine whether NS can offer protection against acquired SNHL. Methods: This study reviewed the literature on the protective effects of Nigella sativa oil (NSO) or TQ against acquired SNHL. We followed the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). A comprehensive literature search was conducted across multiple databases using keywords related to NS and hearing loss. Meta-analyses were performed on eligible studies. Risk of bias was assessed using the Systematic Review Center for Laboratory Animal Experiments (SYRCLE) tool for animal studies. Results: Out of a total of 76 records, 38 duplicates were removed. From the remaining 38, 13 studies met the inclusion criteria. Multiple studies reported a significant protective effect of NS, especially against ototoxicity. The risk of bias across the studies was moderate. Conclusions: Preclinical evidence indicates that NS provides significant protection against acquired SNHL. These protective effects are attributed to their antioxidant, anti-apoptotic, and anti-inflammatory properties. Overall, our systematic review highlights NS as a promising candidate for preventing SNHL. Full article
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