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Special Issues
Cerebrovascular Disease: Symptoms, Diagnosis and Current Treatment
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Cerebrovascular Disease: Symptoms, Diagnosis and Current Treatment

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Clinical Neurology".

Deadline for manuscript submissions: 30 August 2024 | Viewed by 971

Special Issue Editors

Dr. Alba Scerrati

E-Mail Website
Guest Editor
1. Department of Neurosurgery, S. Anna University Hospital, Via Aldo Moro, 44124 Ferrara, Italy
2. Department of Translational Medicine, University of Ferrara, Via Aldo Moro, 44124 Ferrara, Italy
Interests: skull-based surgery; neurovascular surgery; cerebrovascular diseases; cerebrospinal fluid (CSF) dynamics
Dr. Giorgio Mantovani

E-Mail Website
Guest Editor Assistant
1. Department of Translational Medicine and for Romagna, University of Ferrara, 44121 Ferrara, Italy
2. Department of Neurosurgery, University Hospital of Ferrara, 44121 Ferrara, Italy
Interests: cerebrovascular circulation; cerebrospinal fluid (CSF) dynamics; functional neurosurgery for pain

Special Issue Information

Dear Colleagues,

Cerebrovascular diseases are a group of conditions that affect blood flow and the blood vessels in the brain. These can be caused by different kind of alterations, including atherosclerosis, thrombosis, embolisms. We can categorize these diseases as stroke, transient ischemic attack (TIA), aneurysm, and vascular malformation. Arteries are most commonly involved, but veins can also be affected by these kinds of diseases.

The aim of this Special Issue is to collate papers presenting new evidence and novelties about cerebrovascular disease, both for arterial diseases and especially for the less commonly reported venous diseases affecting the brain.

Dr. Alba Scerrati
Guest Editors

Dr. Giorgio Mantovani
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • ischemic stroke
  • cerebral aneurysms
  • cerebral vascular malformation
  • cerebral venous disease
  • cerebral venous thrombosis

Published Papers (1 paper)

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Research

14 pages, 1394 KiB  
Article
Natural History and Predictors for Hemorrhage in Supratentorial Brain Arteriovenous Malformations
by Ioana Miron, Viorel M. Prună, Dan M. Visarion, George E. D. Petrescu and Radu M. Gorgan
J. Clin. Med. 2024, 13(13), 3760; https://doi.org/10.3390/jcm13133760 - 27 Jun 2024
Viewed by 783
Abstract
Background/Objectives: Approximately half of the patients harboring supratentorial brain arterio-venous malformations (stAVMs) present with hemorrhage, and another considerable proportion suffer from epileptic seizures. An important milestone in the management of this vascular pathology is acknowledging their natural history, especially across long periods of [...] Read more.
Background/Objectives: Approximately half of the patients harboring supratentorial brain arterio-venous malformations (stAVMs) present with hemorrhage, and another considerable proportion suffer from epileptic seizures. An important milestone in the management of this vascular pathology is acknowledging their natural history, especially across long periods of time. The aim of this study was to assess the predictive factors for hemorrhage and for epileptic seizures as presenting symptoms in stAVMs. Methods: We retrospectively analyzed patients with stAVMs admitted to our institution between 2012 and 2022 and evaluated predictive factors for hemorrhage and the risk factors associated with epileptic seizures. Results: The cohort included 169 patients, 78 of them (46.2%) presenting with intracerebral hemorrhage (ICH). Seventy-seven (45.5%) patients suffered from epileptic seizures. The annual hemorrhagic rate was 1.28%/year. Unruptured lesions (p = 0.001, OR 3.1, 95% CI 1.6–6.2), superficial venous drainage (p = 0.007, OR 2.7, 95% CI 1.3–5.7) and large nidus size (p = 0.025, OR 4, 95% CI 1.2–13.5) were independently associated with seizures. Among unruptured lesions, superficial venous drainage (OR 2.6, p = 0.036, 95% CI 1.06–6.3) and frontal/temporal/parietal location (OR 2.7, p = 0.040, 95 CI% 1.04–6.9) significantly increased the risk of seizures as a presenting symptom in multivariate analysis. Patients younger than 18 (p = 0.003, OR 4.5, 95% CI 1.6–12.2), those with AVMs < 3 cm (p = 0.03, OR 2, 95% CI 1.07–3.9) or those with deep located AVMs (p = 0.035, OR 2.3, 95% CI 1.06–5.1) presented statistically more often with ICH in multivariate regression. Small size (HR 1.8, 95% CI 1.09–3, p = 0.022) and exclusively deep venous drainage (HR 2.2, 95% CI 1.2–4, p = 0.009) were independent predictors for ICH, in time-dependent birth-to-diagnosis analysis. After shifting the birth-to-diagnosis curve by 10 years, unique arterial feeder demonstrated a positive correlation with ICH presentation as well. Conclusions: Small AVMs, those with exclusively deep venous drainage, unique arterial feeder or deep location may pose higher hemorrhagic risks for the patient, and therapeutic strategies should be tailored accordingly. When managing unruptured brain AVMs, it is important to consider the risk of developing seizures, in addition to the lifelong risk of hemorrhage, in determining the optimal treatment approach for each patient. Full article
(This article belongs to the Special Issue Cerebrovascular Disease: Symptoms, Diagnosis and Current Treatment)
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