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Selected Papers from the 3rd International Online Conference on Clinical Medicine

A special issue of Journal of Clinical Medicine (ISSN 2077-0383).

Deadline for manuscript submissions: 28 April 2026 | Viewed by 3279

Special Issue Editors

Prof. Dr. Kent Doi

E-Mail Website
Guest Editor
Department of Emergency and Critical Care Medicine, The University of Tokyo, Tokyo, Japan
Interests: emergency medicine; critical care medicine; intensive care medicine; fluorescence microscopy; cell biology; molecular biology; neuroscience; acute kidney injury and sepsis
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Francisco Guillen-Grima

E-Mail Website
Guest Editor
1. Department of Preventive Medicine, Clinica Universidad de Navarra, University of Navarra, Pamplona, Spain
2. Navarra Medical Research Institute (IdiSNA), Pamplona, Spain
3. Center for Biomedical Research Network Epidemiology and Public Health (CIBERESP), Madrid, Spain
4. Department of Health Sciences, Public University of Navarra, Pamplona, Spain
Interests: epidemiology; preventive medicine; public health; methodology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The 3rd International Online Conference on Clinical Medicine (IOCCM 2025) (https://sciforum.net/event/IOCCM2025), organized by MDPI’s open access journal Journal of Clinical Medicine (Impact Factor 3.0), will take place online from November 17 to 19, 2025. This conference aims to offer a virtual platform for leading scientists to share their latest research discoveries and participate in stimulating discussions. The main topics of the conference include the following:

• Cardiology & Cardiovascular Medicine;
• Nephrology & Urology;
• Emergency Medicine;
• Nuclear Medicine & Radiology;
• General Surgery;
• Clinical Rehabilitation;
• Pulmonology;
• Anesthesiology.

Below are the key dates relating to the conference:

- Abstract Submission: 18 August 2025
- Acceptance Notification: 20 September 2025
- Registration Deadline: 3 November 2025

This Special Issue aims to compile extended versions of the proceedings papers from the conference. Participation in the conference and the publication of abstracts are free of charge. Researchers submitting an abstract to the conference can publish an article in this Special Issue with a discount on the article processing charge if the abstract is accepted.

Prof. Dr. Kent Doi
Prof. Dr. Francisco Guillen-Grima
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cardiology
  • cardiovascular medicine
  • nephrology
  • urology
  • emergency medicine
  • nuclear medicine & radiology
  • general surgery
  • clinical rehabilitation
  • respiratory medicine
  • anesthesiology

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (4 papers)

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Research

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13 pages, 599 KB  
Article
Epidemiological Characteristics of Acute Coronary Syndrome Patients at Ogulin General Hospital over a Ten-Year Period
by Marijana Pavlovic, Ivana Sovic, Igor Barkovic, Gordana Starcevic-Klasan, Zeljko Jovanovic and Bojan Miletic
J. Clin. Med. 2026, 15(9), 3267; https://doi.org/10.3390/jcm15093267 (registering DOI) - 24 Apr 2026
Abstract
Background/Objectives: Cardiovascular diseases remain one of the major public health challenges in Croatia, with coronary artery disease (CAD) as the most prevalent. The uneven development and concentration of healthcare facilities in urban areas suggest that rural regions lag in providing adequate healthcare. [...] Read more.
Background/Objectives: Cardiovascular diseases remain one of the major public health challenges in Croatia, with coronary artery disease (CAD) as the most prevalent. The uneven development and concentration of healthcare facilities in urban areas suggest that rural regions lag in providing adequate healthcare. Methods: This quantitative, retrospective study included 732 patients diagnosed with acute coronary syndrome (ACS) who were treated between 1 January 2014 and 31 December 2023 at Ogulin General Hospital, Croatia. Data were extracted from the hospital information system, and statistical analyses were performed, with p < 0.05 considered significant. Results: The analysis showed a decreasing trend in hospitalizations of patients with STEMI (Z = −3.574; p < 0.001) and an increase in hospitalizations of patients with NSTEMI (Z = 3.124; p = 0.002). No seasonal (χ2 = 26.33; p = 0.238) or gender differences (χ2 = 3.348; p = 0.188) were observed. A significant association between age and ACS occurrence was observed (χ2 = 57.35; p < 0.001). The proportion of patients transferred to another health institution for further treatment was low (39.21%), particularly among patients with STEMI (12.89%). Conclusions: The results of this study indicate changes in the dynamics of ACS occurrence during the observed ten-year period. The number of hospitalizations is decreasing significantly, with a very low number of transfers of patients with STEMI; at the same time, there is an increase in hospitalizations of patients with NSTEMI. The study did not show statistically significant seasonal or gender differences in the incidence of ACS, while the incidence of NSTEMI increases with the age of the patients. These results emphasize the need for further improvement in the organization of healthcare for patients with ACS in the rural area served by Ogulin General Hospital. Full article
(This article belongs to the Special Issue Selected Papers from the 3rd International Online Conference on Clinical Medicine)
16 pages, 755 KB  
Article
Obstructive Sleep Apnea in Patients with Significant Coronary Artery Disease: An Underdiagnosed Condition
by Monika Kowalik-Pandyra, Klaudia Piwowar, Michał Tworek, Larysa Bielecka, Małgorzata Mazur, Anna Kabłak-Ziembicka and Jakub Podolec
J. Clin. Med. 2026, 15(8), 2877; https://doi.org/10.3390/jcm15082877 - 10 Apr 2026
Viewed by 244
Abstract
Background: Obstructive sleep apnoea (OSA) is a highly prevalent yet underdiagnosed disorder in patients with cardiovascular disease. Growing evidence suggests a pathophysiological link between OSA and coronary artery disease (CAD); however, the relationship between OSA severity and anatomical complexity of coronary lesions [...] Read more.
Background: Obstructive sleep apnoea (OSA) is a highly prevalent yet underdiagnosed disorder in patients with cardiovascular disease. Growing evidence suggests a pathophysiological link between OSA and coronary artery disease (CAD); however, the relationship between OSA severity and anatomical complexity of coronary lesions remains incompletely understood. Aim: The aim of this study is to assess the prevalence of OSA in patients undergoing coronary angiography and to evaluate the association between sleep-disordered breathing parameters and the severity of CAD expressed by the SYNTAX score. Methods: This prospective study enrolled 103 consecutive patients referred for invasive coronary angiography. All participants underwent overnight type III cardiorespiratory polygraphy. OSA severity was classified according to the Apnea–Hypopnea Index (AHI). The anatomical complexity of CAD was assessed using the SYNTAX score. Linear regression analyses were performed to determine associations between polysomnographic parameters and SYNTAX score. Results: Significant CAD was diagnosed in 74.8% of patients. OSA was highly prevalent, with severe OSA observed in 36.4% of patients with significant CAD compared to 3.8% in those without significant stenoses (p = 0.003). Patients with significant CAD had higher AHI (18.8 vs. 13.5 events/h; p = 0.003), higher oxygen desaturation index (ODI) (19.3 vs. 12.9 events/h; p = 0.003), and greater mean oxygen desaturation (4.1% vs. 3.8%; p = 0.008). In multivariable regression analysis, AHI (B = 0.329; 95% CI [0.083, 0.576]; p = 0.009) and nicotinism (B = 8.693; 95% CI [2.573, 14.814]; p = 0.006) independently predicted higher SYNTAX scores. Interestingly, each 1% increase in snoring percentage was associated with a 0.203-point reduction in SYNTAX score (95% CI [−0.339, −0.068]; p = 0.004). Conclusions: OSA is highly prevalent in patients undergoing coronary angiography and is independently associated with greater anatomical complexity of CAD. Sleep-disordered breathing, particularly AHI and nocturnal hypoxemia, may represent important non-traditional risk markers of advanced coronary atherosclerosis. Systematic screening for OSA should be considered in patients with suspected or confirmed CAD. Full article
(This article belongs to the Special Issue Selected Papers from the 3rd International Online Conference on Clinical Medicine)
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23 pages, 2726 KB  
Article
Qoppa as a New Pan-Tumor Synthetic Parameter Derived from Tumor-Associated Biomarkers for Identifying Oncology Patients at High Risk of Metastasis: A Prospective Pilot Study
by Javier Diaz-Santos, Alba Rodriguez-Valle, Beatriz Berrocal-Gavilan, Olivia Urquizar-Rodriguez and Silvia Montoro-Garcia
J. Clin. Med. 2026, 15(2), 846; https://doi.org/10.3390/jcm15020846 - 20 Jan 2026
Viewed by 379
Abstract
Background/Objective: Early detection of metastatic progression remains a major challenge in precision oncology. Conventional radiological imaging cannot reliably identify micrometastatic disease. Although circulating tumor DNA is promising for minimal residual disease detection, organ-derived response biomarkers reflecting tissue adaptation to secreted factors remain unexplored. [...] Read more.
Background/Objective: Early detection of metastatic progression remains a major challenge in precision oncology. Conventional radiological imaging cannot reliably identify micrometastatic disease. Although circulating tumor DNA is promising for minimal residual disease detection, organ-derived response biomarkers reflecting tissue adaptation to secreted factors remain unexplored. We hypothesized that integrating such biomarkers with global laboratory parameters would generate a synthetic variable with improved discrimination for de novo metastasis and mortality. Methods: This prospective observational pilot study enrolled 30 patients (median age 64.4 years; 56.7% female) with heterogeneous solid malignancies. Peripheral blood biomarkers responsive to tumor-secreted soluble factors (n = 11) were quantified using a multiplexed beads Luminex immunoassay. Global analytical parameters (n = 20) were derived from routine laboratory assessments. Hierarchical agglomerative clustering analysis generated two synthetic variables: Stigma (Ϛ) and Qoppa (Ϙ). Receiver operating characteristic curve analysis, Kaplan–Meier survival analysis, and Cox regression were used to evaluate the performance. Results: Qoppa demonstrated acceptable discriminatory performance for de novo metastasis (AUC = 0.78). For mortality prediction, performance varied by disease status (overall AUC = 0.78): superior in non-metastatic patients (AUC = 0.98) but negligible in those with baseline metastases. Kaplan–Meier analysis confirmed significant survival differences (p = 0.042 overall survival; p = 0.024 for metastasis-free survival in the non-metastatic subgroup). Differences in biomarker expression and clinical variables (stage, tumor burden, and metastatic burden) were observed between the high and low Qoppa strata. Conclusions: In this small heterogeneous pilot cohort, Qoppa provides a proof of concept that integrating organ-derived response biomarkers with routine laboratory parameters may capture clinically relevant signals for metastatic risk stratification in oncology patients. This composite parameter supports the generation of hypotheses for future biomarker-driven research and clinical test development. External validation in larger multicenter cohorts is required before clinical implementation. Full article
(This article belongs to the Special Issue Selected Papers from the 3rd International Online Conference on Clinical Medicine)
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Review

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14 pages, 233 KB  
Review
The Clinical and Medico-Legal Aspects in the Challenge of Transfusion-Free Organ Transplants: A Scoping Review
by Matteo Bolcato, Ludovico Fava, Aryeh Shander, Christoph Zenger, Kevin M. Trentino, Mario Chisari, Vanessa Agostini, Ivo Beverina, Giandomenico Luigi Biancofiore and Vincenzo De Angelis
J. Clin. Med. 2025, 14(15), 5444; https://doi.org/10.3390/jcm14155444 - 1 Aug 2025
Cited by 1 | Viewed by 1327
Abstract
Background: Patient blood management (PBM) strategies have been shown to significantly reduce the use of blood products and enabled surgical procedures to be carried out safely without the need for transfusions. This evidence has raised questions about the possibilities of the “extreme” [...] Read more.
Background: Patient blood management (PBM) strategies have been shown to significantly reduce the use of blood products and enabled surgical procedures to be carried out safely without the need for transfusions. This evidence has raised questions about the possibilities of the “extreme” application of PBM strategies for complex surgical interventions, such as organ transplants, even in patients in whom it is not possible to proceed with transfusion. The aim of this scoping review was to identify and describe the current evidence available in the medical literature on the transplant of the four main solid organs: kidney, heart, liver, and lung in patients declining blood transfusions. Methods: A comprehensive literature search was conducted using PubMed from January 2000 to February 2025. Only articles reporting cases, case series, population samples, or comparative studies describing solid organ transplantation without the use of blood components were included. The results are presented separately for each solid organ. Results: Kidney: Nine studies were included, seven of which reported case reports or case series of kidney or kidney–pancreas transplants, and two articles were comparative studies. Liver: Nine studies reported bloodless liver transplants, eight were case reports or case series, and one was a comparative observational study. Heart: Five studies were included, four of which were case reports of heart transplants; in addition there was a comparative study describing eight heart transplants without the use of blood components to 16 transfusable transplant patients. Lung: Five studies reporting lung transplant without transfusion were reported, four of which were case reports performed in the absence of deaths, and two of which were bilateral. Furthermore, there was an article describing two single lung transplants without the use of blood components compared to ten transfusable transplant patients. Conclusions: The analysis performed demonstrates the possibility, depending on the organ, of performing solid organ transplant procedures without the use of blood components in selected and carefully prepared patients by experienced multidisciplinary teams. Full article
(This article belongs to the Special Issue Selected Papers from the 3rd International Online Conference on Clinical Medicine)
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