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Sarcopenia Across the Lifespan: Risk Factors, Mechanisms, and Management in Aging and Disease

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Orthopedics".

Deadline for manuscript submissions: 20 January 2026 | Viewed by 510

Special Issue Editors


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Guest Editor
Department of Health Sciences, Faculty of Health Sciences, University of Burgos, 09001 Burgos, Spain
Interests: cell culture; molecular biology; pharmaceutical development; kinetics; medicinal and pharmaceutical chemistry and biochemistry

Special Issue Information

Dear Colleagues,

Sarcopenia, defined by the progressive loss of muscle mass and function, remains a key challenge in aging populations. However, its impact is not limited to older adults—it also affects people living with chronic illnesses and other health conditions. This Special Issue aims to delve into the diverse facets of sarcopenia, from its underlying risk factors to current and emerging strategies for prevention and treatment. Topics will include the role of nutrition, physical activity, and pharmacological approaches, as well as the exploration of novel biomarkers, genetic influences, and other relevant contributors to muscle health. By bringing clinical perspectives, this Special Issue seeks to present a well-rounded overview of current findings and opportunities to enhance care and outcomes for those affected, regardless of age.

Prof. Dr. Juan Mielgo-Ayuso
Dr. Natalia Busto
Guest Editors

Manuscript Submission Information

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Keywords

  • sarcopenia
  • aging
  • chronic disease
  • risk factors
  • muscle physiology
  • prevention
  • nutrition
  • exercise
  • treatment strategies

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Published Papers (1 paper)

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Research

12 pages, 747 KB  
Article
Relationship Between Bone Metabolic Markers and Presence of Sarcopenia in Patients with Type 2 Diabetes Mellitus: A Cross-Sectional Study
by Tomoyuki Matsuyama, Yoshitaka Hashimoto, Noriyuki Kitagawa, Takafumi Osaka, Masahide Hamaguchi and Michiaki Fukui
J. Clin. Med. 2025, 14(17), 5973; https://doi.org/10.3390/jcm14175973 - 24 Aug 2025
Viewed by 345
Abstract
Objectives: We investigated the relationship between bone metabolic markers or bone mineral density (BMD) and sarcopenia in patients with type 2 diabetes mellitus (T2DM). Methods: In this cross-sectional study involving 119 subjects (76 women and 43 men), bone metabolic markers were [...] Read more.
Objectives: We investigated the relationship between bone metabolic markers or bone mineral density (BMD) and sarcopenia in patients with type 2 diabetes mellitus (T2DM). Methods: In this cross-sectional study involving 119 subjects (76 women and 43 men), bone metabolic markers were evaluated by bone alkaline phosphatase and bone tartrate-resistant acid phosphatase (TRACP-5b). BMD was measured using the dual-energy X-ray absorptiometry method, and sarcopenia was diagnosed using skeletal muscle mass index (SMI), evaluated by body composition measurement and handgrip strength. Results: Significant correlation was observed between handgrip strength or SMI and TRACP-5b in both sexes (correlation coefficients were −0.50 in handgrip strength and −0.41 in SMI in men; −0.25 in handgrip strength and −0.21 in SMI in women). Furthermore, significant correlation was observed between handgrip strength or SMI and BMD of the femoral neck in both sexes (correlation coefficients were 0.33 in handgrip strength and 0.44 in SMI in men; 0.34 in handgrip strength and 0.47 in SMI in women). The concentrations of TRACP-5b with sarcopenia were significantly higher than those without (643.8 ± 261.9 vs. 455.7 ± 165.6 mU/dL), and BMD of femoral neck with sarcopenia was significantly lower than those without (0.54 ± 0.12 vs. 0.66 ± 0.16 g/cm2). TRACP-5b (odds ratio 1.05, 95% confidence interval 1.01–1.10) and femoral neck BMD (odds ratio 0.30, 95% confidence interval 0.14–0.68) were associated with the presence of sarcopenia after adjustment for confounders. Conclusions: TRACP-5b and BMD of the femoral neck were associated with sarcopenia in patients with T2DM. Full article
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