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Clinical Advances in Specimen Collection and Laboratory Testing in Population...
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Clinical Advances in Specimen Collection and Laboratory Testing in Population Health

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Clinical Laboratory Medicine".

Deadline for manuscript submissions: 25 October 2024 | Viewed by 3061

Special Issue Editors

Dr. Jing Cao

E-Mail Website
Guest Editor
Department of Pathology, University of Texas Southwestern Medical Center Dallas, Dallas, TX, USA
Interests: population health; laboratory operation; biomarker
Special Issues, Collections and Topics in MDPI journals
Dr. Xin Yi

E-Mail Website
Guest Editor
Department of Clinical Pathology and Genomic Medicine, Houston Methodist Hospital, Weill Cornell Medical College, Houston, TX, USA
Interests: clinical diagnostics; laboratory medicine; population health

Special Issue Information

Dear Colleagues,

Collaboration between population health and clinical diagnostics has been at the forefront of our fight against SARS-CoV-2. Advances in specimen collection and laboratory testing have collectively informed healthcare policy and actions, creating a multitude of future opportunities. There is a need to better understand what the available techniques are, as well as potential diagnostic targets, and how to practice such interventions.

The SARS-COVID 2 pandemic and healthcare outreach to broader populations are shifting diagnostic service from hospital and clinic-based to population-based testing. Novel collection methods such as self-collection are particularly suited to support primary screening and treatment monitoring in vulnerable groups. Testing technologies such as isothermal nucleic acid identification and ultra-sensitive POCT protein quantification have expanded our capacity in diagnostics. This issue provides a timely update on feasibility and accuracy of these approaches, as well as on implementation of workflow, focusing on at-home use of specimen collection devices and analyzers, isothermal technology for nucleic acid identification and quantification, and ultra-sensitive protein quantification on POCT devices.

Overall, this issue aims to educate readers on the methodology of specimen collection and laboratory assays and to present pioneer findings in this field. The scope covers but is not limited to sample types of saliva, nasal swab, blood, and non-invasive body fluid, analytes of hormone, drug, protein, bacterial, and viral antigen and nucleic acid. Review papers, original research, and editorials are invited.

Dr. Jing Cao
Dr. Xin Yi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • self-collection
  • saliva
  • POCT
  • diagnostics
  • infectious disease
  • dry blood spot

Published Papers (2 papers)

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Research

11 pages, 1170 KiB  
Article
Accuracy-Based Glomerular Filtration Rate Assessment by Plasma Iohexol Clearance in Kidney Transplant Donors
by Zhicheng Jin, Rongrong Huang, Paul Christensen, Roger L. Bertholf and Xin Yi
J. Clin. Med. 2023, 12(18), 6054; https://doi.org/10.3390/jcm12186054 - 19 Sep 2023
Viewed by 917
Abstract
Background: An accurate measurement of the glomerular filtration rate (GFR) is essential for detecting renal insufficiency in living kidney donors. Iohexol is a “near-ideal” exogenous filtration marker for GFR measurements that has attracted increasing interest in clinical practice because it is non-toxic, non-radioactive, [...] Read more.
Background: An accurate measurement of the glomerular filtration rate (GFR) is essential for detecting renal insufficiency in living kidney donors. Iohexol is a “near-ideal” exogenous filtration marker for GFR measurements that has attracted increasing interest in clinical practice because it is non-toxic, non-radioactive, readily available, and easy to measure. In this study, we aimed to set up a laboratory test to conveniently assess the plasma clearance of iohexol in living kidney donors. Methods: A workflow was established in the institution’s infusion clinic to administer iohexol and to collect three timed blood samples from renal transplant donors. Iohexol was thereafter measured by liquid chromatography–tandem mass spectrometry (LC-MS/MS). The serum proteins were precipitated and the supernatant containing iohexol was diluted prior to the LC-MS/MS analysis. The LC-MS/MS method was developed on a Thermo Vanquish UHPLC coupled with a TSQ Endura triple quadruple mass spectrometer with a total run time of 2.5 min. The analytical performance of the method was assessed. Results: The LC-MS/MS method demonstrated a good analytical performance. To calculate the iohexol clearance rate and the GFR, automated data integration and a result calculation were accomplished by using a custom Python script. Automated result reporting was achieved using a laboratory informatics system (LIS) vendor’s direct media interface. Conclusions: We developed and implemented a laboratory test to assess the plasma clearance of iohexol. A workflow was established in the hospital to reliably measure the GFR in living kidney donors, with a potential to be further expanded into other areas where an accurate GFR measurement is needed. Full article
(This article belongs to the Special Issue Clinical Advances in Specimen Collection and Laboratory Testing in Population Health)
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11 pages, 3284 KiB  
Article
Evaluation of the Accuracy of Cr and BUN Using the ABL90 FLEX PLUS Blood Gas Analyzer and the Equivalence of Candidate Specimens for Assessment of Renal Function
by Ha-Jin Lim, Seung-Yeob Lee and Hyun-Jung Choi
J. Clin. Med. 2023, 12(5), 1940; https://doi.org/10.3390/jcm12051940 - 1 Mar 2023
Cited by 1 | Viewed by 1738
Abstract
Background: The ABL90 FLEX PLUS (Radiometer) is a blood gas analyzer that also provides creatinine (Cr) and blood urea nitrogen (BUN) results. We assessed the accuracy of the ABL90 FLEX PLUS to measure Cr and BUN and find suitable candidate specimens against primary [...] Read more.
Background: The ABL90 FLEX PLUS (Radiometer) is a blood gas analyzer that also provides creatinine (Cr) and blood urea nitrogen (BUN) results. We assessed the accuracy of the ABL90 FLEX PLUS to measure Cr and BUN and find suitable candidate specimens against primary specimens (heparinized whole-blood (H-WB)). Methods: Paired H-WB, serum, and sodium-citrated whole-blood (C-WB) samples (105) were collected. The Cr and BUN levels in the H-WB using the ABL90 FLEX PLUS were compared with those of the serum using four automated chemistry analyzers. The suitability of the candidate specimens was assessed at each medical decision level according to the CLSI guideline EP35-ED1. Results: The respective mean differences of the ABL90 FLEX PLUS for the Cr and BUN were below −0.10 and −3.51 mg/dL compared to the other analyzers. The systematic differences between the serum and the H-WB at the low, medium, and high medical decision levels were all 0% for Cr, but those of the C-WB were −12.96%, −11.81%, and −11.30%, respectively. Regarding imprecision, the SDserum/SDH-WB ratios at each level were 0.14, 1.41, and 0.68, whereas the SDC-WB/SDH-WB ratios were 0.35, 2.00, and 0.73, respectively. Conclusions: The ABL90 FLEX PLUS provided Cr and BUN results comparable with the four widely used analyzers. Among the candidates, the serum was suitable for Cr testing using the ABL90 FLEX PLUS, while the C-WB did not satisfy the acceptance criteria. Full article
(This article belongs to the Special Issue Clinical Advances in Specimen Collection and Laboratory Testing in Population Health)
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

  • Smart phone-enabled self-collection specimen analyzing and reporting
  • Evaluation of saliva specimen and collection device for SARS-CoV-2 diagnostics

  • Dry blood specimen in the therapeutic drug monitoring

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