The Future of Inflammatory Biomarkers: Challenges and Clinical Integration

A special issue of Journal of Clinical Medicine (ISSN 2077-0383).

Deadline for manuscript submissions: 31 January 2025 | Viewed by 267

Special Issue Editors


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Guest Editor
Institute of Medical Sciences, Rzeszów University, Rzeszów, Poland
Interests: biomarkers; inflammation; oxidative stress; molecular biology
Special Issues, Collections and Topics in MDPI journals

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Guest Editor Assistant
Institute of Medical Sciences, Rzeszów University, Rzeszów, Poland
Interests: biomarkers; inflammation; oxidative stress; molecular biology

Special Issue Information

Dear Colleagues,

Current research underscores the complexity and variability of inflammatory responses, necessitating precise biomarkers for improved clinical outcomes. Key problems to be addressed include the identification of specific biomarkers that can reliably differentiate between various inflammatory conditions, the development of standardized protocols for biomarker measurement, and the integration of these biomarkers into routine clinical practice.

The scope of this Special Issue encompasses the discovery of novel inflammatory biomarkers, validation of existing biomarkers, and their clinical application in many diseases. It also includes studies on the molecular mechanisms underlying biomarker expression and their role in disease pathogenesis. Researchers are encouraged to contribute original research articles, reviews, and clinical studies that provide insights into the utility of inflammatory biomarkers, ultimately aiming to enhance patient management and therapeutic strategies. Through this focused collection of research, the Special Issue seeks to bridge gaps in knowledge and foster the translation of biomarker research into clinical practice.

Dr. Sabina Galiniak
Guest Editors

Dr. Marek Biesiadecki
Guest Editor Assistant

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Keywords

  • inflammatory marker
  • inflammation
  • biomarker
  • cancers
  • rheumatoid arthritis
  • inflammatory bowel disease
  • respiratory diseases

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Published Papers (1 paper)

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Research

9 pages, 751 KiB  
Article
Predictive Value of Neutrophil–Lymphocyte Ratio and Other Inflammation Indices in Febrile Seizures in Children
by Yakup Söğütlü and Uğur Altaş
J. Clin. Med. 2024, 13(17), 5330; https://doi.org/10.3390/jcm13175330 - 9 Sep 2024
Abstract
Objective: There is increasing evidence for the effect of inflammation on the etiology of febrile seizure (FS) patients. We aimed to investigate the role of easily accessible inflammatory markers such as the neutrophil–lymphocyte ratio (NLR), systemic immune-inflammation index (SII), systemic inflammation response index [...] Read more.
Objective: There is increasing evidence for the effect of inflammation on the etiology of febrile seizure (FS) patients. We aimed to investigate the role of easily accessible inflammatory markers such as the neutrophil–lymphocyte ratio (NLR), systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), neutrophil–lymphocyte–platelet ratio (NLPR), and pan-immune-inflammation value (PIV) in febrile seizure. Methods: A total of 300 children, including 100 with febrile convulsions (FS), 100 febrile controls (FCs), and 100 healthy controls (HCs), were included in this retrospective study. The FS group was compared with the FC and HC groups in terms of these inflammatory indexes. Results: Between the FS group and the FC group, the neutrophil count was significantly higher in the FS group (p = 0.001) and the lymphocyte count was significantly lower (p < 0.001). The NLR (p < 0.001), SII (p < 0.001), SIRI (p < 0.001), NLPR (p < 0.001), and PIV (p < 0.001) were significantly higher in the FS group than in both the FC and healthy control groups. The optimal cut-off values for predicting FS in febrile conditions were 3.59> for NLR, >870.47 for SII, >1.96 for SIRI, 0.96> for NLPR, and >532.75 for PIV. Conclusions: The inflammatory indices are inexpensive, easily accessible hematological markers that can contribute to the diagnosis of FS. Full article
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