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Female Infertility: Advances in Diagnosis and Treatment
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Female Infertility: Advances in Diagnosis and Treatment

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Obstetrics & Gynecology".

Deadline for manuscript submissions: closed (25 February 2023) | Viewed by 8991

Special Issue Editor

Prof. Dr. Jean Marc Ayoubi

E-Mail Website
Guest Editor
Department of Obstetrics and Gynecology, Hopital Foch, Suresnes, France
Interests: uterus transplantation; infertility; surgery; endometriosis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Infertility is growing worldwide. This phenomenon is the result of different conditions and structural diseases, as well as more subtle and complex events.

With this in mind, we propose this Special Issue with the aim to highlight and address current research on female and male infertility diagnosis and treatment. We consider this to be of paramount importance for the incredible and dynamic field of ART, and hope that targeting this specific area of interest could increase cumulative ART outcomes.

This Special Issue invites original clinical and basic research articles and reviews regarding the following topics: (1) female and male infertility; (2) infertility treatments.

Potential topics might include, but are not limited to, the following:

  • Female infertility;
  • Infertility diagnosis;
  • Assisted reproductive technologies;
  • Medical therapies;
  • AMH;
  • Poor responders.

Prof. Dr. Jean Marc Ayoubi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • infertility workup
  • male infertility
  • female infertility
  • infertility treatment
  • ART
  • poor responders

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Related Special Issue

Published Papers (4 papers)

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Research

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12 pages, 290 KiB  
Article
Association between Leukemia Inhibitory Factor Gene Polymorphism and Clinical Outcomes among Young Women with Poor Ovarian Response to Assisted Reproductive Technology
by Yung-Liang Liu, Chun-I Lee, Chung-Hsien Liu, En-Hui Cheng, Shun-Fa Yang, Hsueh-Yu Tsai, Maw-Sheng Lee and Tsung-Hsien Lee
J. Clin. Med. 2023, 12(3), 796; https://doi.org/10.3390/jcm12030796 - 19 Jan 2023
Cited by 2 | Viewed by 1568
Abstract
Background: Does the presence of single-nucleotide polymorphisms (SNPs) in the leukemia inhibitory factor (LIF) gene affect ovarian response in infertile young women? Methods: This was a case–control study recruiting 1744 infertile women between January 2014 to December 2015. The 1084 eligible patients were [...] Read more.
Background: Does the presence of single-nucleotide polymorphisms (SNPs) in the leukemia inhibitory factor (LIF) gene affect ovarian response in infertile young women? Methods: This was a case–control study recruiting 1744 infertile women between January 2014 to December 2015. The 1084 eligible patients were stratified into four groups using the POSEIDON criteria. The gonadotropin-releasing hormone receptor (GnRHR), follicle-stimulating hormone receptor (FSHR), anti-Müllerian hormone (AMH), and LIF SNP genotypes were compared among the groups. The distributions of LIF and FSHR among younger and older patients were compared. Clinical outcomes were also compared. Results: The four groups of poor responders had different distributions of SNP in LIF. The prevalence of LIF genotypes among young poor ovarian responders differed from those of normal responders. Genetic model analyses in infertile young women revealed that the TG or GG genotype in the LIF resulted in fewer oocytes retrieved and fewer mature oocytes relative to the TT genotypes. In older women, the FSHR SNP genotype contributed to fewer numbers of mature oocytes. Conclusions: LIF and FSHR SNP genotypes were associated with a statistically significant reduction in ovarian response to controlled ovarian hyperstimulation in younger and older women with an adequate ovarian reserve, respectively. Full article
(This article belongs to the Special Issue Female Infertility: Advances in Diagnosis and Treatment)
12 pages, 1678 KiB  
Article
Rupture Prediction for Microscopic Oocyte Images of Piezo Intracytoplasmic Sperm Injection by Principal Component Analysis
by Naomi Yagi, Hyodo Tsuji, Takashi Morimoto, Tomohiro Maekawa, Shimpei Mizuta, Tomomoto Ishikawa and Yutaka Hata
J. Clin. Med. 2022, 11(21), 6546; https://doi.org/10.3390/jcm11216546 - 4 Nov 2022
Cited by 3 | Viewed by 1821
Abstract
Assisted reproductive technology (ART) has progressed rapidly, resulting in a great improvement in the clinical pregnancy ratio. When applying the protocol of piezo intracytoplasmic sperm injection (Piezo-ICSI), it is very important to puncture the zona pellucida and the oocyte cytoplasmic membrane without rupturing [...] Read more.
Assisted reproductive technology (ART) has progressed rapidly, resulting in a great improvement in the clinical pregnancy ratio. When applying the protocol of piezo intracytoplasmic sperm injection (Piezo-ICSI), it is very important to puncture the zona pellucida and the oocyte cytoplasmic membrane without rupturing the oocyte cytoplasmic membrane. Previous studies have shown that the poor extensibility of the oocyte cytoplasmic membrane might be closely related to rupture. However, no consensus has been reached regarding how the quality of the oocyte for extensible ability or rupture possibility affects the surfaces of the oocyte on the microscopic frames. We conducted this study to provide evidence that artificial intelligence (AI) techniques are superior for predicting the tendency of oocyte rupture before puncturing on Piezo-ICSI. To inspect it, we provided a retrospective trial of 38 rupture oocytes and 55 nonruptured oocytes. This study marked the highest accuracy of 91.4% for predicting oocytes rupture using the support-vector machine method of machine learning. We conclude that AI technologies might serve an important role and provide a significant benefit to ART. Full article
(This article belongs to the Special Issue Female Infertility: Advances in Diagnosis and Treatment)
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14 pages, 3788 KiB  
Article
Technical Tips and Tricks after 10 Years of HyFoSy for Tubal Patency Testing
by Roxana-Elena Bohîlțea, Bianca-Margareta Mihai, Cătălina-Diana Stănică, Consuela-Mădălina Gheorghe, Costin Berceanu, Vlad Dima, Alexia-Teodora Bohîlțea, Smaranda Neagu and Radu Vlădăreanu
J. Clin. Med. 2022, 11(19), 5946; https://doi.org/10.3390/jcm11195946 - 8 Oct 2022
Cited by 4 | Viewed by 2604
Abstract
Background: Hysterosalpingo-foam sonography (HyFoSy) has gained popularity in the last decades, as it represents a feasible, well-tolerated, and minimally invasive method of evaluation of tubal patency in cases of infertility. The purpose of this study was to communicate the technical tips and tricks [...] Read more.
Background: Hysterosalpingo-foam sonography (HyFoSy) has gained popularity in the last decades, as it represents a feasible, well-tolerated, and minimally invasive method of evaluation of tubal patency in cases of infertility. The purpose of this study was to communicate the technical tips and tricks based on our experience in performing HyFoSy, with the aim to improve the feasibility, to reduce the pain, and to evaluate pregnancy-obtaining rate after procedure. Methods: Our observational study includes 672 patients from infertile couples who underwent HyFoSy for tubal patency evaluation. During HyFoSy, tubal pathway and patency as well as the level of pain were evaluated. A telephonic questionnaire was conducted in order to assess the pregnancy obtaining rate in the first 3 months and more than 3 months after the procedure. Results: The median age in our group was 33.5 years. Most of our patients (61.16%) underwent HyFoSy in the 8–10 days of the menstrual cycle. Tubal patency was present bilaterally in 86% cases, unilaterally in 11% of patients, and was absent in 3% of cases; 75% of patients related absent or tolerable pain, 17% described HyFoSy as a painful procedure, and 8% experienced extreme pain. After HyFoSy, pregnancy was naturally obtained in 10.86% of cases within the first 3 months after HyFoSy. Conclusions: HyFoSy represents a useful, easy to use, and painless tool in female infertility evaluation and should be considered as a complementary method of the transvaginal ultrasonography, completing the genital tract imaging with information about the hidden part of the standard examination: tubal patency. HyFoSy provides information about patency, caliber regularity, pathway, and occlusion location of the fallopian tubes; therefore, it should be introduced along with transvaginal ultrasound as a first-line infertility exploration method. Full article
(This article belongs to the Special Issue Female Infertility: Advances in Diagnosis and Treatment)
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Review

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15 pages, 23820 KiB  
Review
Global Trends in Research on Cell-Free Nucleic Acids in Obstetrics and Gynecology during 2017–2021
by Wenyan Gao, Hongyue Yang, Wanting Cheng, Xiao Wang, Da Li and Bei Shi
J. Clin. Med. 2022, 11(19), 5545; https://doi.org/10.3390/jcm11195545 - 22 Sep 2022
Viewed by 2224
Abstract
Objectives. The objectives of this study were to identify global trends in research on cell-free deoxyribonucleic acid (cfDNA) from a bibliometric perspective and provide researchers with new research hotspots. Methods. In all, we extracted 5038 pieces of literature from PubMed and 527 articles [...] Read more.
Objectives. The objectives of this study were to identify global trends in research on cell-free deoxyribonucleic acid (cfDNA) from a bibliometric perspective and provide researchers with new research hotspots. Methods. In all, we extracted 5038 pieces of literature from PubMed and 527 articles from the Web of Science Core Collection (WoSCC) database related to cfDNA published from 1 January 2017 to 31 December 2021. For PubMed literature, we employed co-word, biclustering, and strategic diagram analysis to describe the trends in research on cfDNA in the said five years. Then, we used VOSviewer analysis for the WoSCC database to display the trends in research on cfDNA in obstetrics and gynecology during 2017–2021. Results. Strategy diagram analysis of 95 major Medical Subject Headings terms extracted from 5038 pieces of literature indicated that cfDNA sequence analysis for non-invasive prenatal and genetic testing and its application in the fields of neoplasm genetics and diagnosis is a newly emerging immature theme of cfDNA. VOSviewer analysis of 527 articles showed the global trends in research on cfDNA in obstetrics and gynecology, for example, in terms of most influential authors, institutions, countries, journals, and five research hotspots: (1) cfDNA application in prenatal screening and prenatal diagnosis, (2) cfDNA application in assisted reproductive technology, (3) cfDNA application in pre-eclampsia, DNA methylation, etc., (4) cfDNA application in placental dysfunction and fetal growth restriction, and (5) cfDNA application in fetal chromosomal abnormalities (fetal aneuploidy). Conclusions. Comprehensive visual analysis provides information regarding authors, organizations, countries/regions, journals, research hotspots, and emerging topics in the field of cfDNA for obstetrics and gynecology research. This comprehensive study could make it easier to find a partner for project development and build a network of knowledge on this emerging topic. Full article
(This article belongs to the Special Issue Female Infertility: Advances in Diagnosis and Treatment)
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