Trends and Innovations in Regenerative Medicine and Non-Surgical Aesthetics

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Epidemiology & Public Health".

Deadline for manuscript submissions: 20 April 2025 | Viewed by 4381

Special Issue Editors


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Guest Editor
Innovation Aesthetics, London, UK
Interests: non-surgical aesthetics; regenerative medicine; botulinum toxin A; dermal fillers; artificial intelligence; education; ethics and social media

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Guest Editor
Innovation Aesthetics, London, UK
Interests: non-surgical aesthetics; regenerative medicine; ATMPs; regulatory considerations

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Guest Editor
Department of Ophthalmology, The University of British Columbia, Vancouver, BC, Canada
Interests: non-surgical aesthetics; regenerative medicine; botulinum toxin A; dermal fillers; artificial intelligence; education; ethics and social media

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Guest Editor
Department of Plastic and Reconstructive Surgery, Royal Free Hospital, Hampstead, UK
Interests: non-surgical aesthetics; regenerative medicine; botulinum toxin A; dermal fillers; artificial intelligence; education; ethics and social media; regulatory considerations

Special Issue Information

Dear Colleagues,

The field of regenerative medicine and non-surgical aesthetic procedures is undergoing a remarkable transformation, driven by innovative solutions that significantly enhance patient care and outcomes. These advancements are revolutionizing therapeutic and aesthetic treatments, offering new possibilities for both clinicians and patients.

Regenerative medicine, with its potential to restore and regenerate damaged tissues, is becoming increasingly pivotal in clinical practice. Leveraging the body's intrinsic healing mechanisms through the use of stem cells, growth factors, and advanced therapy medicinal products (ATMPs), this field promises substantial advancements. Its applications range from wound healing and cartilage repair to the rejuvenation of aging skin, highlighting its broad therapeutic potential.

Non-surgical aesthetic procedures are gaining unprecedented popularity due to their minimally invasive nature and reduced recovery times. Innovations in this domain include advanced dermal fillers, botulinum toxin A injections, laser therapies, and energy-based devices.

This Special Issue aims to delve into the latest trends and innovations in these two intersecting fields, providing a comprehensive overview of the cutting-edge research and clinical applications that are shaping the future of regenerative medicine and non-surgical aesthetics.

Topics will include the following:

  • Recent advancements in advanced therapy medicinal products (ATMPs);
  • Novel approaches to skin rejuvenation and anti-aging treatments;
  • The role of growth factors and bioactive molecules in tissue repair;
  • Non-invasive techniques for body contouring and skin tightening;
  • The newer preparations and evolving applications of botulinum toxin A;
  • Innovations in dermal fillers for facial rejuvenation;
  • Application of energy devices in non-surgical aesthetics;
  • Integration of AI and machine learning into personalized aesthetic treatments;
  • Safety and efficacy of emerging aesthetic procedures and products;
  • Patient perspectives on, and satisfaction with, non-surgical aesthetic treatments;
  • Regulatory and ethical considerations in regenerative and aesthetic medicine.

This Special Issue will identify gaps in the current knowledge, highlight cutting-edge research, and propose future directions for the integration of regenerative techniques into aesthetic practices. By combining original research and comprehensive review articles, we aim to provide a scholarly overview of the current state of the art and future potential in these dynamic fields.

Dr. Eqram Rahman
Dr. William R. Webb
Prof. Dr. Jean D.A. Carruthers
Prof. Dr. Afshin Mosahebi
Guest Editors

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Keywords

  • regenerative medicine
  • non-surgical aesthetics
  • stem cell therapy
  • ATMPs
  • skin rejuvenation
  • anti-aging treatments
  • growth factors
  • bioactive molecules
  • botulinum toxin A
  • dermal fillers
  • energy devices
  • AI in aesthetics
  • patient satisfaction
  • safety and efficacy
  • regulatory considerations

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Published Papers (1 paper)

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29 pages, 3690 KiB  
Systematic Review
Systematic Review of Platelet-Rich Plasma in Medical and Surgical Specialties: Quality, Evaluation, Evidence, and Enforcement
by Eqram Rahman, Parinitha Rao, Hany Niamey Abu-Farsakh, Chirag Thonse, Imran Ali, Alice E. Upton, Shwetha Y. Baratikkae, Jean D. A. Carruthers, Ash Mosahebi, Nima Heidari and William Richard Webb
J. Clin. Med. 2024, 13(15), 4571; https://doi.org/10.3390/jcm13154571 - 5 Aug 2024
Cited by 1 | Viewed by 3861
Abstract
Background: Platelet-rich plasma (PRP) is widely used in various medical and surgical specialties for its regenerative properties, including aesthetics (facial rejuvenation, hair restoration, and skin tightening) and orthopedics (treatment of tendinitis and osteoarthritis). However, the inconsistent literature on PRP’s efficacy and safety leads [...] Read more.
Background: Platelet-rich plasma (PRP) is widely used in various medical and surgical specialties for its regenerative properties, including aesthetics (facial rejuvenation, hair restoration, and skin tightening) and orthopedics (treatment of tendinitis and osteoarthritis). However, the inconsistent literature on PRP’s efficacy and safety leads to critical knowledge gaps. This systematic review evaluates quality control measures in PRP preparation and application and explores the regulatory environment governing its clinical use. Methods: Following PRISMA guidelines, a comprehensive search was conducted across multiple databases, including PubMed, EMBASE, and Web of Science, for studies published from January 2020 to April 2024. The review included randomized controlled trials (RCTs) involving human participants undergoing PRP treatment for aesthetic or regenerative purposes. Key parameters such as the PRP preparation methods, platelet concentration, and quality control measures were analyzed. The study protocol was registered with PROSPERO (ID: CRD42024557669). Results: Out of 75 RCTs involving 5726 patients, the review identified significant variability in PRP preparation methods and application techniques, including differences in centrifugation protocols and platelet concentration levels. A new evidence-based scoring system, the William–Eqram Scoring System for PRP Quality Reporting (WESS-PQR), was proposed to address these inconsistencies. Correlation analysis revealed a strong positive correlation (r = 0.79) between proper temperature control during preparation and PRP efficacy. Initial platelet count assessment showed a moderate positive correlation (r = 0.57) with efficacy. Conclusions: Standardized PRP preparation protocols and robust regulatory frameworks are urgently needed to ensure the safety and efficacy of PRP treatments. The proposed WESS-PQR scoring system can serve as a valuable tool for clinicians and researchers, promoting consistency and reliability in PRP applications. Full article
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