Challenges in Reproductive Health

Dear Colleagues,

Reproductive health is influenced by a wide range of physiological, pathological, and treatment-related factors that may compromise fertility and long-term reproductive outcomes in both women and men. Advances in reproductive medicine have improved prevention, diagnosis, and management strategies; however, significant clinical challenges remain.

Cancer and its treatments represent a major threat to reproductive function, making fertility preservation an essential component of patient care. Techniques such as oocyte, embryo, and ovarian tissue cryopreservation are now widely used, while emerging approaches—including ovarian tissue transplantation, in vitro follicle growth, artificial ovaries, and fertility-sparing strategies—continue to expand the field. Beyond oncology, reproductive health challenges also encompass endocrine disorders, gynecological and andrological diseases, genetic conditions, aging, and lifestyle-related factors.

The aim of this Special Issue of the Journal of Clinical Medicine is to highlight current challenges and recent advances in reproductive health, with particular attention to fertility preservation and reproductive medicine. We welcome original research articles and reviews addressing both female and male reproductive health, innovative clinical approaches, and strategies to improve short- and long-term reproductive outcomes.

Dr. Loris Marin
Prof. Dr. Guido Ambrosini
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.