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Latest Advances in Degenerative Spinal Disease
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Latest Advances in Degenerative Spinal Disease

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Orthopedics".

Deadline for manuscript submissions: closed (28 December 2022) | Viewed by 3426

Special Issue Editor

Dr. Hidetoshi Nojiri

E-Mail Website
Guest Editor
Department of Orthopedic Surgery, Juntendo University, Tokyo 113-8421, Japan
Interests: cervical spine diseases; lumbar spine diseases; thoracic spine diseases; spinal deformity
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

As a spine surgeon performing surgery in all spine-related fields—including scoliosis in children and spinal degenerative diseases in the elderly—my particular interest in the field of surgery is to reduce the invasiveness of spinal surgery and improve its safety. The most minimally invasive medical care is prevention. We believe that elucidating the mechanisms of spinal degeneration and spinal deformity can prevent the onset and progression of these diseases. My research comprises 20 years of studying tissue degeneration caused by oxidative stress; the spine is composed of bones, cartilage, intervertebral discs, ligaments, and paraspinal muscles and functions. We have shown that excessive oxidative stress in tissue causes age-related degenerative diseases in mice. Building on these findings, we intend to explore clinically problematic neuropathies and spinal deformities through surgical and preventive developments in research.

Fortunately, I had the opportunity to participate in a special project on spinal degenerative diseases. We would like to ask you to report your original research or review the latest findings. We ask for your cooperation so that we can incorporate a special feature with substantial content.

Dr. Hidetoshi Nojiri
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • disc degeneration
  • spinal deformity
  • oxidative stress
  • lumbar spinal canal stenosis
  • foraminal stenosis
  • preventive medicine
  • facet joint osteoarthritis
  • minimally invasive spine surgery
  • sarcopenia
  • regenerative medicine

Published Papers (2 papers)

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Research

9 pages, 1437 KiB  
Article
Correlation of Foraminal Parameters with Patient-Reported Outcomes in Patient with Degenerative Lumbar Foraminal Stenosis
by Yu-Tsung Lin, Jun-Sing Wang, Wei-En Hsu, Yu-Hsien Lin, Yun-Che Wu, Kun-Hui Chen, Chien-Chou Pan and Cheng-Hung Lee
J. Clin. Med. 2023, 12(2), 479; https://doi.org/10.3390/jcm12020479 - 6 Jan 2023
Cited by 1 | Viewed by 1564
Abstract
The relationship between quantitative anatomic parameters in MRI and patient-reported outcomes (PROs) before and after surgery in degenerative lumbar foraminal stenosis remains unknown. We included 58 patients who underwent transforaminal lumbar interbody fusion (TLIF) for single-level degenerative disc disease with foraminal stenosis between [...] Read more.
The relationship between quantitative anatomic parameters in MRI and patient-reported outcomes (PROs) before and after surgery in degenerative lumbar foraminal stenosis remains unknown. We included 58 patients who underwent transforaminal lumbar interbody fusion (TLIF) for single-level degenerative disc disease with foraminal stenosis between February 2013 and June 2020. PROs were evaluated using the visual analog scale (VAS) for back and leg pain, Oswestry Disability Index (ODI), and EuroQol-5D (EQ-5D). The foraminal parameters assessed using preoperative MRI included foraminal height, posterior intervertebral disc height, superior and inferior foraminal width, and foraminal area. The correlation between foraminal parameters and PROs before operation, at 1 year follow-up, and change from baseline were assessed. The associations between the aforementioned parameters were examined using linear regression analysis. The analysis revealed that among these parameters, superior foraminal width was found to be significantly correlated with ODI and EQ-5D at the 1 year follow-up and with change in ODI and EQ-5D from baseline. The associations remained significant after adjustment for confounding factors including age, sex, body mass index, and duration of hospital stay. The results indicated that in degenerative lumbar foraminal stenosis, decreased superior foraminal width was associated with better improvement in disability and quality of life after TLIF. Full article
(This article belongs to the Special Issue Latest Advances in Degenerative Spinal Disease)
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10 pages, 2205 KiB  
Article
Risk Factors for Progressive Spinal Sagittal Imbalance in the Short-Term Course after Total Hip Arthroplasty: A 3 Year Follow-Up Study of Female Patients
by Satoshi Nagatani, Satoru Demura, Satoshi Kato, Tamon Kabata, Yoshitomo Kajino, Noriaki Yokogawa, Daisuke Inoue, Yuki Kurokawa, Motoya Kobayashi, Yohei Yamada, Masafumi Kawai and Hiroyuki Tsuchiya
J. Clin. Med. 2022, 11(17), 5179; https://doi.org/10.3390/jcm11175179 - 1 Sep 2022
Cited by 3 | Viewed by 1502
Abstract
Total hip arthroplasty (THA) for patients with hip osteoarthritis improves hip flexion contracture, subsequently improving spinal sagittal balance. However, in some cases, spinal sagittal imbalance develops in the course after THA, and its risk factors remain unknown. We aimed to investigate the risk [...] Read more.
Total hip arthroplasty (THA) for patients with hip osteoarthritis improves hip flexion contracture, subsequently improving spinal sagittal balance. However, in some cases, spinal sagittal imbalance develops in the course after THA, and its risk factors remain unknown. We aimed to investigate the risk factors of progressive spinal sagittal imbalance after THA. This retrospective cohort study of a prospectively maintained database included female patients aged ≥50 years who underwent THA. Before performing THA, we obtained each patient’s anthropometric and muscle strength measurements and whole-spine radiographs. Three years postoperatively, patients underwent whole-spine radiography to examine changes in the spinal sagittal balance. Patients were assigned into groups on the basis of their preoperative and 3 year postoperative sagittal vertical axis (SVA) values. Patients with 3 year postoperative SVA values ≥40 mm with an increase ≥30 mm were categorized into the imbalance group; the other patients were categorized into the non-imbalance group. Of 103 patients, 11 (10.7%) were in the imbalance group. In multiple logistic regression analysis, preoperative weak abdominal trunk muscle strength (ATMS) (p = 0.007) and small sacral slope (SS) (p = 0.005) were significant risk factors for progressive spinal sagittal imbalance. In conclusion, risk factors for progressive spinal sagittal imbalance after THA were weak preoperative ATMS and small SS. Full article
(This article belongs to the Special Issue Latest Advances in Degenerative Spinal Disease)
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