Pregnancy Management of Preeclampsia

Dear Colleagues,

Severe preeclampsia is a complex disease process and serious pregnancy complication characterized by hypertension often accompanied by proteinuria and multiorgan dysfunction, occurring in 2% to 8% of all pregnancies.

In severe cases, an attack of eclamptic seizures, premature separation of the placenta, DIC, intracranial hemorrhage, HELLP syndrome, renal failure, and even maternal and fetal death may occur. Preeclampsia and eclampsia are two of the most serious pregnancy-related complications and the main causes of death of pregnant and delivering women. The mortality rate of young mothers reaches 5–20%. The mortality rate of fetuses and infants associated with this severe pregnancy complication is estimated at 7–40 %, and this is mainly the result of such complications as preterm placental abruption, placental insufficiency, intrauterine death of fetus, and complications arising from prematurity.

Although we currently know several pathogenetic mechanisms that may lead to the development of preeclampsia, the exact etiology of these specific for human pregnancy diseases is not fully explained. Currently, there is no effective treatment to stop the progress of clinical deterioration. Delivery is the only definitive treatment. Although other treatment options are limited, childbirth is not always favorable for the fetus, especially at a time far from the expected date of delivery, originating prematurity-associated consequences for the newborn.

The aim of this Special Issue is to present an updated approach to clinical issues around pregnancy complicated by preeclampsia with special focus on diagnosis, clinical management, complications, timing, and mode of delivery.

Clinical researchers, gynecologists–obstetricians, and maternal–fetal medicine specialists are welcomed to submit their works that contribute to improve pregnancy outcomes in preeclamptic women and lowering maternal and fetal mortality and morbidity.

Thus, all original research articles or reviews on topics related to pregnancy in women with preeclampsia and HELLP syndrome are welcome in this Special Issue. Topics will include:

1. Clinical management of preeclampsia, eclampsia, and severe hypertension in pregnant women—diagnosis, complications, surveillance, mode of delivery.
2. HELLP syndrome—diagnosis, emergency management, timing and mode of delivery, surveillance. Corticosteroid therapy—advantages and disadvantages.
3. Preeclampsia—complications such as acute kidney insufficiency, eclampsia seizures, pulmonary oedema, and fetal growth restriction.

Dr. Marzena Laskowska
Prof. Dr. Oleszczuk Jan
Dr. Anna Błażewicz
Guest Editors

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• preeclampsia
• eclamptic convulsions
• HELLP syndrome
• pregnancy complicated by hypertension
• emergency complications
• fetal growth restriction in preeclampsia