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Urologic Neoplasms: Recent Advances and Future Perspectives

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Oncology".

Deadline for manuscript submissions: 31 October 2025 | Viewed by 366

Special Issue Editor


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Guest Editor
1. Department of Urology, Chaim Sheba Medical Center, Tel-Hashomer, Ramat Gan 5262000, Israel
2. Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv 6997801, Israel
Interests: robotic laparoscopic and endoscopic approaches to benign and malignant urologic conditions; medical manage-ment of stone disease; surgical management of stone disease
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Special Issue Information

Dear Colleagues,

Over the last decade, we have witnessed tremendous advancement in the field of urinary and male genital system neoplasms. On one hand, we have seen the introduction of new protocols for the treatment of malignancies, some of which recruit the patient's immune system to eradicate threats. On the other hand, robotic systems developed by various manufacturers have arrived on the market, facilitating precision in surgical maneuvers and, as a consequence, improving surgical and oncological outcomes.

This Special Issue of Journal of Clinical Medicine will focus on advances in the surgical and medical treatment of various urological and male genital system neoplasms. Authors are welcome to submit original research and review articles on the medical and surgical treatment of urological neoplasms involving the prostate, kidney, ureter, urinary bladder, penis, and testes.

Prof. Dr. Dorit E. Zilberman
Guest Editor

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Keywords

  • robotic surgery
  • laparoscopic surgery
  • immunotherapy
  • chemotherapy
  • radiotherapy
  • prostate cancer
  • renal cancer
  • bladder cancer
  • upper urinary tract neoplasm
  • testicular cancer
  • penile cancer

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Published Papers (1 paper)

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Research

17 pages, 885 KB  
Article
The Prognostic Roles of Systemic Inflammatory Markers Before Abiraterone or Enzalutamide Therapy in Metastatic Castration-Resistant Prostate Cancer
by Harun Muğlu, Erdem Sünger, Lamia Şeker Can, Jamshid Hamdard, Özgür Açıkgöz, Özcan Yıldız, Ömer Fatih Ölmez, Mesut Şeker and Ahmet Bilici
J. Clin. Med. 2025, 14(18), 6536; https://doi.org/10.3390/jcm14186536 - 17 Sep 2025
Viewed by 183
Abstract
Objectives: The objective of this study was to investigate the prognostic value of systemic inflammatory markers (SIMs)—namely, the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR)—on survival outcomes and treatment responses in patients with metastatic castration-resistant prostate cancer (mCRPC) receiving abiraterone (ABI) or enzalutamide [...] Read more.
Objectives: The objective of this study was to investigate the prognostic value of systemic inflammatory markers (SIMs)—namely, the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR)—on survival outcomes and treatment responses in patients with metastatic castration-resistant prostate cancer (mCRPC) receiving abiraterone (ABI) or enzalutamide (ENZA) therapy. Methods: In this two-center retrospective observational study, researchers analyzed clinical data from 106 patients diagnosed with mCRPC. The cut-offs for NLR and PLR were determined to be 2.83 and 156, respectively, and their effects on progression-free survival (PFS) and overall survival (OS) were evaluated using Kaplan–Meier and Cox regression analyses. Changes in SIMs before and after ABI/ENZA treatment were assessed using the Wilcoxon signed-rank test. Results: Lower NLR (≤2.83) and PLR (≤156) were significantly associated with longer PFS and OS; however, in multivariate analysis, only high PLR emerged as an independent adverse prognostic factor for OS (HR: 2.01; p = 0.026). Meanwhile, treatment response was an independent predictor of PFS, and no significant changes were observed in the mean platelet volume (MPV), platelet distribution width (PDW), or platelet–large cell ratio (P-LCR) after treatment. Conclusions: SIMs, such as NLR and especially PLR, may serve as practical and accessible tools for predicting survival in mCRPC patients; however, further prospective studies are warranted. Full article
(This article belongs to the Special Issue Urologic Neoplasms: Recent Advances and Future Perspectives)
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