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Skin Cancer: Epidemiology, Disease Burden, Pathophysiology, Diagnosis, and Therapeutic Approaches
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Skin Cancer: Epidemiology, Disease Burden, Pathophysiology, Diagnosis, and Therapeutic Approaches

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Oncology".

Deadline for manuscript submissions: closed (31 August 2021) | Viewed by 5704

Special Issue Editor

Dr. Kyung Eun Kim

E-Mail Website
Guest Editor
1. Department of Cosmetic Sciences, Sookmyung Women’s University, Seoul 04310, Korea
2. Department of Health Industry, Sookmyung Women’s University, Seoul 04310, Korea
3. Nano-Bio Resources Center, Sookmyung Women’s University, Seoul 04310, Korea
Interests: skin cancer; skin immunology; tumor immunity; cytokines; therapeutic approaches

Special Issue Information

Dear Colleagues,

Skin cancer, including basal cell carcinoma, squamous cell carcinomas, and melanoma, has continued to increase worldwide in the past few decades, and millions of non-melanoma and melanoma skin cancers are now occurring. Additionally, statistics show that one of the three most-diagnosed cancers is skin cancer. In particular, melanoma has the lowest incidence of skin cancer, but the prognosis is known to be the worst.

Fortunately, novel and more effective treatments for various types of cancers are being developed, and there have been tremendous efforts, especially for the early detection and primary prevention of cancer. However, despite these efforts, the incidence of melanoma is currently increasing at a much faster rate than other types of cancer. In addition, melanoma is a cancer that is highly resistant to chemotherapy because of its strong metastatic ability and resistance to apoptosis. Therefore, the early detection of melanoma and the suggestion of innovative treatment methods are very important.

Toward this end, many researchers need to study the development of cancer immunotherapy, discover biomarkers for the early detection of skin cancer and predict treatment efficacy, the role of the microenvironment of skin cancer, genetic predisposition to control the prognosis of skin cancer, and molecular differences.

This Special Issue will focus on clinical data analysis, such as integrated analytical and bioinformatics approaches, in addition to research on the mechanisms and pathogenesis of skin cancer and important clinical relevance.

Dr. Kyung Eun Kim
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • skin cancer
  • melanoma
  • multi-omics
  • meta-analysis
  • clinical research
  • prognosis
  • biomarker
  • novel therapeutic approaches

Published Papers (2 papers)

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Research

18 pages, 5631 KiB  
Article
Prognostic Value of Interleukin-32 Expression and Its Correlation with the Infiltration of Natural Killer Cells in Cutaneous Melanoma
by Ji Young Kang and Kyung Eun Kim
J. Clin. Med. 2021, 10(20), 4691; https://doi.org/10.3390/jcm10204691 - 13 Oct 2021
Cited by 6 | Viewed by 1764
Abstract
Interleukin-32 (IL-32) is well known as a proinflammatory cytokine that is expressed in various immune cells and cancers. However, the clinical relevance of IL-32 expression in cutaneous melanoma has not been comprehensively studied. Here, we identified the prognostic value of IL32 expression using [...] Read more.
Interleukin-32 (IL-32) is well known as a proinflammatory cytokine that is expressed in various immune cells and cancers. However, the clinical relevance of IL-32 expression in cutaneous melanoma has not been comprehensively studied. Here, we identified the prognostic value of IL32 expression using various systematic multiomic analyses. The IL32 expressions were significantly higher in cutaneous melanoma than in normal tissue, and Kaplan–Meier survival analysis showed a correlation between IL32 expression and good prognosis in cutaneous melanoma patients. In addition, we analyzed the correlation between IL32 expression and the infiltration of natural killer (NK) cells to identify a relevant mechanism between IL32 expression and prognosis in cutaneous melanoma (p = 0.00031). In the relationship between IL32 expression and the infiltration of NK cells, a negative correlation was found in resting NK cells (rho = −0.38, p = 3.95 × 10−17) whereas a strong positive correlation was observed only in active NK cells (rho = 0.374, p = 1.23 × 10−16). Moreover, IL32 expression was markedly positively correlated with the cytolytic molecules, such as granzyme and perforin. These data suggest that IL32 expression may increase patient survival through the infiltration and activation of NK cells, representative anticancer effector cells, in cutaneous melanoma. Collectively, this study provides the prognostic value of IL32 expression and its potential role as an effective predictive biomarker for NK cell infiltration in cutaneous melanoma. Full article
(This article belongs to the Special Issue Skin Cancer: Epidemiology, Disease Burden, Pathophysiology, Diagnosis, and Therapeutic Approaches)
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10 pages, 1048 KiB  
Article
Prognostic Value of Preoperative Inflammatory Markers in Melanoma Patients with Brain Metastases
by Matthias Schneider, Niklas Schäfer, Christian Bode, Valeri Borger, Lars Eichhorn, Frank A. Giordano, Erdem Güresir, Muriel Heimann, Yon-Dschun Ko, Felix Lehmann, Anna-Laura Potthoff, Alexander Radbruch, Christina Schaub, Katjana S. Schwab, Johannes Weller, Hartmut Vatter, Ulrich Herrlinger, Jennifer Landsberg and Patrick Schuss
J. Clin. Med. 2021, 10(4), 634; https://doi.org/10.3390/jcm10040634 - 7 Feb 2021
Cited by 12 | Viewed by 3267
Abstract
Background: Metastatic melanoma disease is accompanied by highly systemic inflammatory responses. The prognostic value of preoperative laboratory inflammation markers in brain metastatic melanoma patients has not been adequately investigated so far. Methods: Preoperative inflammatory blood parameters were correlated to overall survival (OS) rates [...] Read more.
Background: Metastatic melanoma disease is accompanied by highly systemic inflammatory responses. The prognostic value of preoperative laboratory inflammation markers in brain metastatic melanoma patients has not been adequately investigated so far. Methods: Preoperative inflammatory blood parameters were correlated to overall survival (OS) rates in melanoma patients that underwent surgery for brain metastasis (BM) between 2013 and 2019 at the authors’ institution. Receiver operating characteristic (ROC) analyses were used for cutoff determination of routine laboratory parameters. Results: Median OS in the present cohort of 30 melanoma patients with surgically treated BM was 7 months (95% confidence interval (CI) 5.7–8.3). Initial elevated C-reactive protein (CRP) levels (>10 mg/L), neutrophil-to-lymphocyte ratio (NLR) ≥ 4, platelet-to-lymphocyte ratio (PLR) ≥ 145, and lymphocyte-to-monocyte ratio (LMR) < 2 were associated with significantly reduced OS rates. Conclusions: The present study identifies several preoperative peripheral inflammatory markers as indicators for poor prognosis in melanoma patients with BM undergoing neurosurgical treatment. Elevated initial CRP values, higher NLR and PLR, and lower LMR were associated with reduced OS and, thus, might be incorporated into preoperative interdisciplinary treatment planning and counseling for affected patients. Full article
(This article belongs to the Special Issue Skin Cancer: Epidemiology, Disease Burden, Pathophysiology, Diagnosis, and Therapeutic Approaches)
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