Research Progress of Rheumatic Immune Diseases
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Immunology".
Deadline for manuscript submissions: closed (10 August 2024) | Viewed by 227
Special Issue Editor
Interests: immunology; common variable immunodeficiency; systemic lupus erythematosus; rheumatologic diseases; rheumatoid arthritis; autoinflammatory diseases
Special Issue Information
Dear Colleagues,
Rheumatology is a constantly evolving discipline. The prognosis of many rheumatologic diseases has greatly improved as a result of substantial progress in disease management, even though their pathogenetic aspects, both genetic and environmental, remain unresolved. The application of molecular and cellular profiling techniques revealed marked heterogeneity of the pathomechanisms of some diseases, particularly rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), contributing to the variation of their clinical phenotype and treatment response. Ongoing efforts to dissect this marked disease heterogeneity in RA and in SLE represent a challenge for the future development of precision medicine and therapeutic target validation approaches in these diseases. Unfortunately, the new treatments do not appear to decrease the incidence of some potentially life-threatening complications, such as macrophage activation syndrome and interstitial lung diseases in systemic-onset juvenile idiopathic arthritis/still disease. Therefore, the understanding of immune dysregulation underlying these pathologies is relevant to identifying biomarkers for their early identification. However, the risk/benefit profile of the new therapeutic agents in real-world rheumatology practice deserves further investigation and surveillance. Autoinflammatory disorders (inflammasomopathies and interferonopathies), at the crossroads between immunology and rheumatology, can masquerade as rheumatologic diseases; therefore, the knowledge of their extremely heterogeneous presentation, molecular diagnostic approach, and promising targeted treatment encompasses the rheumatologic expertise.
The present topic aims to collect original contributions that represent novel insights into rheumatologic/autoinflammatory disease pathology and clinical treatment of both adults and children, in order to offer the scientific community knowledge and actionable suggestions for clinical practice.
Prof. Dr. Rita Consolini
Guest Editor
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Keywords
- systemic lupus erythematosus
- rheumatologic diseases
- rheumatoid arthritis
- autoinflammatory diseases
- inflam-masomopathies
- interferonopathies
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