Journal of Clinical Medicine, Volume 13, Issue 20
October-2 2024 - 266 articles
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Cover Story: Hypertension is emerging as a modifiable risk factor for major neurocognitive disorders, contributing to neurodegenerative processes through vascular damage, inflammation, and blood–brain barrier disruption. However, the role of antihypertensive treatments in preventing or treating cognitive decline remains unclear, with mixed evidence varying by antihypertensive class and the type of neurocognitive disorder, including delirium, Alzheimer’s disease, vascular dementia, Lewy body dementia, and frontotemporal dementia. The complex, bidirectional relationship between hypertension and these disorders—along with variations in hypertension definitions, diagnostic criteria, and confounding factors like medication adherence—underscores the need for long-term studies to clarify the potential therapeutic benefits of antihypertensive treatments. View this paper