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Renal Failure: Treatment Advances and Future Directions
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Renal Failure: Treatment Advances and Future Directions

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Nephrology & Urology".

Deadline for manuscript submissions: 20 December 2024 | Viewed by 8944

Special Issue Editor

Dr. Nada Alachkar

E-Mail Website
Guest Editor
Division of Nephrology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Interests: recurrent glomerular diseases in transplanted kidney biopsy; incompatible kidney transplant; high immunologic risk kidney transplant; biomarkers in kidney transplant; outcome of deceased donor kidney transplant recipients with positive crossmatch; highly sensitized patients; responses to desensitization treatments and post-transplant outcomes; late AMR; responses to therapy and outcome; recurrence of atypical HUS; the role of eculizumab; the recurrence of focal segmental glomerulosclerosis post-kidney transplantation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Acute kidney injury/failure and chronic kidney disease are major causes of mortality and morbidities.

There has been a significant improvement in our understanding of the pathophysiology, causes, and biomarkers in renal failure.

However, despite all efforts, there are still significant limited options in the management of renal failure. In a large number of patients, acute kidney injury and chronic kidney disease lead to end-stage kidney disease that requires renal replacement treatment with dialysis or kidney transplant.

The reviews will highlight up-to-date data on the prevention and management of kidney failure in the native and transplanted kidney.

The aim is to provide a source of knowledge to clinicians and researchers in order to improve the management of patients with kidney failure.

Dr. Nada Alachkar
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • kidney failure
  • acute kidney injury
  • chronic kidney disease
  • kidney transplant
  • glomerular diseases
  • acute kidney transplant dysfunction

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Published Papers (2 papers)

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Review

25 pages, 1325 KiB  
Review
Care of Adults with Advanced Chronic Kidney Disease
by Sanjivani Shrestha, Kanza Haq, Divyanshu Malhotra and Dipal M. Patel
J. Clin. Med. 2024, 13(15), 4378; https://doi.org/10.3390/jcm13154378 - 26 Jul 2024
Viewed by 475
Abstract
Chronic kidney disease (CKD) impacts over 10% of the global population. Adults with CKD face significant morbidity and mortality. As kidney disease progresses, the risk of adverse outcomes increases. Here, we present an overview of strategies to care for adults with advanced CKD [...] Read more.
Chronic kidney disease (CKD) impacts over 10% of the global population. Adults with CKD face significant morbidity and mortality. As kidney disease progresses, the risk of adverse outcomes increases. Here, we present an overview of strategies to care for adults with advanced CKD (stage 4–5 CKD, not receiving kidney replacement therapy). We aim to guide clinicians through several aspects of CKD care, ranging from recommended laboratory assessments to interdisciplinary support for patients as they plan for kidney replacement therapy (dialysis, transplantation, or conservative management). We incorporate considerations of health equity and person-centered care, empowering clinicians to deliver high-quality care to people with CKD. Full article
(This article belongs to the Special Issue Renal Failure: Treatment Advances and Future Directions)
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18 pages, 619 KiB  
Review
Treatment of Acute Kidney Injury: A Review of Current Approaches and Emerging Innovations
by Christina Tamargo, Mohamad Hanouneh and C. Elena Cervantes
J. Clin. Med. 2024, 13(9), 2455; https://doi.org/10.3390/jcm13092455 - 23 Apr 2024
Viewed by 8049
Abstract
Acute kidney injury (AKI) is a complex and life-threatening condition with multifactorial etiologies, ranging from ischemic injury to nephrotoxic exposures. Management is founded on treating the underlying cause of AKI, but supportive care—via fluid management, vasopressor therapy, kidney replacement therapy (KRT), and more—is [...] Read more.
Acute kidney injury (AKI) is a complex and life-threatening condition with multifactorial etiologies, ranging from ischemic injury to nephrotoxic exposures. Management is founded on treating the underlying cause of AKI, but supportive care—via fluid management, vasopressor therapy, kidney replacement therapy (KRT), and more—is also crucial. Blood pressure targets are often higher in AKI, and these can be achieved with fluids and vasopressors, some of which may be more kidney-protective than others. Initiation of KRT is controversial, and studies have not consistently demonstrated any benefit to early start dialysis. There are no targeted pharmacotherapies for AKI itself, but some do exist for complications of AKI; additionally, medications become a key aspect of AKI management because changes in renal function and dialysis support can lead to issues with both toxicities and underdosing. This review will cover existing literature on these and other aspects of AKI treatment. Additionally, this review aims to identify gaps and challenges and to offer recommendations for future research and clinical practice. Full article
(This article belongs to the Special Issue Renal Failure: Treatment Advances and Future Directions)
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