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Interstitial Lung Disease: From Diagnosis to Treatment
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Interstitial Lung Disease: From Diagnosis to Treatment

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Pulmonology".

Deadline for manuscript submissions: 20 February 2025 | Viewed by 505

Special Issue Editors

Dr. Takeshi Saraya

E-Mail
Guest Editor
Department of Respiratory Medicine, Kyorin University School of Medicine, Mitaka-shi 181-8611, Japan
Interests: mycoplasma pneumoniae; pneumonia; diagnostic methods for pleural effusion; respiratory disease and infection; collagen vascular disease related interstitial pneumonia; general medicine; physical diagnosis; lung sounds
Special Issues, Collections and Topics in MDPI journals
Dr. Tomohisa Baba

E-Mail Website
Guest Editor
Department of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Center, Yokohama 236-0051, Japan
Interests: interstitial lung disease; interstitial pneumonia; non-small-cell lung cancer

Special Issue Information

Dear Colleagues,

Interstitial lung diseases (ILDs) have diverse differential diagnoses, including drug-induced, infection, and connective tissue disease (CTD) related ILDs. Furthermore, acute exacerbation (AE) is a critical issue for ILDs. This issue focuses on the recent advances in the multidisciplinary aspects of ILDs.

In this Special Issue, we welcome authors to submit papers on the clinical advance of ILDs in terms of diagnosis (i.e., radiology, bronchoalveolar lavage fluid), immunopathogenesis of pulmonary fibrosis, clinical approach to ILDs, pathology, and treatment (effect of antifibrotic agents). We also welcome sarcoidosis, hypersensitivity pneumonitis, and rare and orphan interstitial lung diseases.

Dr. Takeshi Saraya
Dr. Tomohisa Baba
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • interstitial pneumonia
  • diagnosis
  • virus infection
  • collagen vascular disease-related interstitial pneumonia
  • differen-tial diagnosis
  • lung sounds

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Published Papers (1 paper)

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Research

12 pages, 2762 KiB  
Article
Clinical Evaluation of Acute Exacerbation of Interstitial Lung Disease in a Single Tertiary Center: Perspectives before and after the Coronavirus Disease 2019 Pandemic
by Ryo Takagi, Takeshi Saraya, Sho Yamada, Kei Nakajima, Kazuyuki Doi, Takatora Akizawa, Narishige Ishikawa, Nozomi Kurokawa, Fumi Kobayashi, Hiroki Nunokawa, Jumpei Aso, Yasuo Nakamoto, Manabu Ishida, Mitsuru Sada, Kojiro Honda, Keitaro Nakamoto, Saori Takata and Haruyuki Ishii
J. Clin. Med. 2024, 13(19), 5733; https://doi.org/10.3390/jcm13195733 - 26 Sep 2024
Abstract
Background/Objectives: Acute exacerbation (AE) of interstitial lung disease (ILD) is a major challenge. This study aimed to retrospectively investigate occurrences of AEs in patients with ILDs, including idiopathic pulmonary fibrosis (IPF), non-IPF (iNSIP: idiopathic nonspecific interstitial pneumonia), and connective tissue disease (CTD)-associated ILDs [...] Read more.
Background/Objectives: Acute exacerbation (AE) of interstitial lung disease (ILD) is a major challenge. This study aimed to retrospectively investigate occurrences of AEs in patients with ILDs, including idiopathic pulmonary fibrosis (IPF), non-IPF (iNSIP: idiopathic nonspecific interstitial pneumonia), and connective tissue disease (CTD)-associated ILDs (CTD-ILDs), at a single tertiary center before and after the coronavirus disease 2019 (COVID-19) pandemic. The study aimed to clarify the seasonal and regional trends of AEs of ILDs, assess the roles of viral and bacterial infections, and identify key prognostic factors for patient outcomes. Methods: We conducted a retrospective review of hospitalized adult patients with AEs of ILDs from January 2019 to February 2024. Results: A total of 93 patients were enrolled: IPF (n = 42), iNSIP (n = 37), and CTD-ILDs (n = 14). The median age was 80 years (interquartile range: 74.0–86.0 years), with males comprising 64.5% (n = 60). AEs of ILDs predominantly occurred in winter and were particularly notable after summer 2023, coinciding with the lifting of COVID-19-related travel restrictions in Japan. Patient referrals from different areas (Northern Tama, East and/or Southern Tama, and other Tokyo metropolitan areas) were evenly distributed throughout the study period. Viral infections were detected in only two patients (SARS-CoV-2), and bacterial infections included methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa. The Cox regression analysis identified serum lactate dehydrogenase levels ≥350 IU/L and tachypnea (respiratory rate ≥ 30 breaths per min) on admission as prognostic factors for mortality, with a hazard ratio [HR] of 2.783 (95% confidence interval [CI]: 1.480–5.235, p = 0.001) and an HR of 3.332 (95% CI: 1.710–6.492, p < 0.001), respectively. Conclusions: AEs of ILDs predominantly occur in winter, and viral and bacterial infections are infrequently detected. Elevated serum LDH levels and tachypnea are crucial prognostic markers for mortality. This study highlights the seasonal trend in the AE of ILD and emphasizes the importance of specific prognostic indicators in clinical practice. Full article
(This article belongs to the Special Issue Interstitial Lung Disease: From Diagnosis to Treatment)
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