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Esophagectomy and Non-esophagectomy: Different Treatment Strategies on Esophageal Cancer
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Esophagectomy and Non-esophagectomy: Different Treatment Strategies on Esophageal Cancer

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Oncology".

Deadline for manuscript submissions: closed (15 December 2022) | Viewed by 3523

Special Issue Editors

Dr. William Bryson Robb

E-Mail Website
Guest Editor
1. Department of Upper GI Surgery, Beaumont Hospital, D09 V2N0 Dublin, Ireland
2. Department of Surgery, Royal College of Surgeons in Ireland, D02 VN51 Dublin, Ireland
Interests: esophageal cancer; minimally invasive and robotic surgery; enhanced recovery after surgery protocols; survivorship
Dr. Jarlath Christopher Bolger

E-Mail Website
Guest Editor
1. Division of Thoracic Surgery, University Health Network, Toronto, ON M5G 2C4, Canada
2.Department of Surgery, Royal College of Surgeons in Ireland, D02 VN51 Dublin, Ireland
Interests: esophageal cancer; minimally invasive and robotic surgery; clinical trials; survivorship; proteomics

Special Issue Information

Dear Colleagues,

Esophageal cancer remains a challenging cancer to treat. Recent years have seen advances in patient outcomes after esophagectomy, and expected survival rates have improved. The reasons for these advances include incremental improvement in oncological therapy, early intervention and endoscopic therapies, improved surgical techniques and perioperative pathways, and now the advent of immune-based therapy.

While surgery remains the cornerstone of treatment, increasingly non-surgical or organ preserving interventions are becoming realistic in a variety of settings. A debate exists on the limits of the role of endoscopic resection as well as strategies of a “wait and watch” approach after apparent complete clinical response to neoadjuvant treatment. The selection of patients for surgery is also evolving as staging modalities improve, imaging modalities change, and minimally invasive surgery advances.

In this Special Edition entitled “Esophagectomy and Non-Esophagectomy: Different treatment strategies for Esophageal Cancer”, we look forward to collating a selection of papers which reflect the challenges and changes in the current management of esophageal cancer. It is hoped that this issue will provide both an update as well as further stimulus for debate and research.

Dr. William Bryson Robb
Dr. Jarlath Christopher Bolger
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • esophageal cancer
  • esophagectomy
  • minimally invasive esophagectomy
  • robotic surgery
  • endoscopic resection
  • immunotherapy
  • tumor immunology
  • clinical trials

Published Papers (2 papers)

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11 pages, 1266 KiB  
Article
Prognostic Effect of the Dose of Radiation Therapy and Extent of Lymphadenectomy in Patients Receiving Neoadjuvant Chemoradiotherapy for Esophageal Squamous Carcinoma
by Chu-Pin Pai, Ling-I Chien, Chien-Sheng Huang, Han-Shui Hsu and Po-Kuei Hsu
J. Clin. Med. 2022, 11(17), 5059; https://doi.org/10.3390/jcm11175059 - 28 Aug 2022
Cited by 1 | Viewed by 1317
Abstract
Neoadjuvant chemoradiotherapy has been used for patients with locally advanced esophageal squamous cell carcinoma (ESCC). However, the optimal dose of radiation therapy and the effect of lymphadenectomy after neoadjuvant therapy on patient outcomes are uncertain. We retrospectively reviewed the data of patients who [...] Read more.
Neoadjuvant chemoradiotherapy has been used for patients with locally advanced esophageal squamous cell carcinoma (ESCC). However, the optimal dose of radiation therapy and the effect of lymphadenectomy after neoadjuvant therapy on patient outcomes are uncertain. We retrospectively reviewed the data of patients who received neoadjuvant therapy followed by surgery for ESCC. Overall survival (OS), disease-free survival (DFS), and perioperative outcomes were compared between patients who received radiation doses of 45.0 Gy (PF4500) and 50.4 Gy (PF5040). Subgroup analysis was performed based on the number of lymph nodes removed through lymph node dissection (LND). Data from a total of 126 patients were analyzed. No significant differences were found in 3-year OS and DFS between the PF4500 and PF5040 groups (OS: 45% versus 54%, p = 0.218; DFS: 34% versus 37%, p = 0.506). In both groups, no significant differences were found in 3-year locoregional-specific DFS between patients with a total LND number ≤17 and >17 (PF4500, 35% versus 50%, p = 0.291; PF5040 group, 45% versus 46%, p = 0.866). The PF5040 and PF4500 groups were comparable in terms of survival outcomes and local control. Although no additional survival benefits were identified, the extent of LND should not be altered according to the radiation dose. Full article
(This article belongs to the Special Issue Esophagectomy and Non-esophagectomy: Different Treatment Strategies on Esophageal Cancer)
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12 pages, 5546 KiB  
Systematic Review
Application of Intraoperative Neuromonitoring (IONM) of the Recurrent Laryngeal Nerve during Esophagectomy: A Systematic Review and Meta-Analysis
by Boyang Chen, Tianbao Yang, Wu Wang, Weifeng Tang, Jinbiao Xie and Mingqiang Kang
J. Clin. Med. 2023, 12(2), 565; https://doi.org/10.3390/jcm12020565 - 10 Jan 2023
Cited by 3 | Viewed by 1777
Abstract
Background: recurrent laryngeal nerve palsy (RLNP) is a common and severe complication of esophagectomy in esophageal cancer (EC). Several studies explored the application of intraoperative neuromonitoring (IONM) in esophagectomy to prevent RLNP. The purpose of this study was to conduct a systematic review [...] Read more.
Background: recurrent laryngeal nerve palsy (RLNP) is a common and severe complication of esophagectomy in esophageal cancer (EC). Several studies explored the application of intraoperative neuromonitoring (IONM) in esophagectomy to prevent RLNP. The purpose of this study was to conduct a systematic review and meta-analysis to evaluate the value of IONM in esophagectomy for EC. Methods: an electronic of the literature using Google Scholar, PubMed, Embase, and Web of Science (data up to October 2022) was conducted and screened to compare IONM-assisted and conventional non-IONM-assisted esophagectomy. RLNP, the number of mediastinal lymph nodes (LN) dissected, aspiration, pneumonia, chylothorax, anastomotic leakage, the number of total LN dissected, postoperative hospital stay and total operation time were evaluated using Review Manager 5.4.1. Result: ten studies were ultimately included, with a total of 949 patients from one randomized controlled trial and nine retrospective case–control studies in the meta-analysis. The present study demonstrated that IONM reduced the incidence of RLNP(Odds Ratio (OR) 0.37, 95% Confidence Interval (CI) 0.26–0.52) and pneumonia (OR 0.58, 95%CI 0.41–0.82) and was associated with more mediastinal LN dissected (Weighted Mean Difference (WMD) 4.75, 95%CI 3.02–6.48) and total mediastinal LN dissected (WMD 5.47, 95%CI 0.39–10.56). In addition, IONM does not increase the incidence of aspiration (OR 0.4, 95%CI 0.07–2.51), chylothorax (OR 0.55, 95%CI 0.17–1.76), and anastomotic leakage (OR 0.78, 95%CI 0.48–1.27) and does not increase the total operative time (WMD −12.33, 95%CI −33.94–9.28) or postoperative hospital stay (WMD −2.07 95%CI −6.61–2.46) after esophagectomy. Conclusion: IONM showed advantages for preventing RLNP and pneumonia and was associated with more mediastinal and total LN dissected in esophagectomy. IONM should be recommended for esophagectomy. Full article
(This article belongs to the Special Issue Esophagectomy and Non-esophagectomy: Different Treatment Strategies on Esophageal Cancer)
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