Hidradenitis Suppurativa (HS): Research Advances in Pathogenesis, Diagnosis and Treatment
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Dermatology".
Deadline for manuscript submissions: closed (20 November 2021) | Viewed by 13133
Special Issue Editor
Special Issue Information
Dear Colleagues,
Hidradenitis suppurativa (HS) is increasingly recognized as one of the main dermatological disorders in western countries affecting 1% of the general population, mainly vulnerable individuals with a low socioeconomic status. The diagnosis is far from simple, as dermatologists have to look for the presence of chronic and unremitting nodules, abscesses, and sinus tracts in skin folds as the only criteria to diagnose HS. To make the diagnosis even more difficult, most patients often conceal HS as typical malodorous lesions in genital areas are associated with strong feelings of shame. As a result, HS diagnosis takes, in median, 7 years to be made, the patients moved from one treatment to another without obtaining any improvement, thus losing faith in the medical follow-up and frequently falling in to depression and, in the most severe cases, suicidal attempts.
The situation does not improve after diagnosis is finally established. Poor knowledge of HS pathogenesis reflects the lack of an effective treatment. Most patients receive a first treatment combining analgesics and topical and systemic antibiotics with HS often mistaken for folliculitis. Some dermatologists prescribe sulfonamides, immunosuppressants or isotreonin, used to treat acne. Adalimumab (an anti-TNF-a) is currently used off-label for severe to moderate cases, although not all patients respond to the treatment. Medical treatments seldom result in a cure, and the aggravation of lesions often leads to surgical resection of the skin of affected areas.
Over the last few years, however, research into HS pathogenesis has sensibly increased, giving new hopes for a faster diagnosis and effective treatments. The present Special Issue aims to present the last findings in HS pathogenesis that can improve its diagnosis and treatment.
Dr. Michele Boniotto
Guest Editor
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Keywords
- hidradenitis suppurativa
- genetics
- omics
- hair follicle
- Th17
- neutrophils
- plasma cells
- biologics
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