Functionalized Cellulose: Sustainable Chemical Process and Biomedical Applications

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983). This special issue belongs to the section "Biomaterials for Drug Delivery".

Deadline for manuscript submissions: closed (20 September 2023) | Viewed by 1974

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Department of Bioproducts and Biosystems, Aalto University, Espoo, Finland
Interests: PROTACs; E3-ligase; ubiquitination; occupancy driven pharmacology; SNIPERs; PHOTACs; E3 ligase ligand-linker conjugates; molecular glues; photocaged PROTACs
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Special Issue Information

Dear Colleagues,

Cellulose is the most available biopolymer in Nature. It is composed of the linear homopolymer of glucose 1,4 alpha linkage chains. The molecular orientation of these chains facilitates a high H-bonds network, leading to high packing and crystallinity. Moreover, the presence of such composition at the molecular level provides cellulose with ample mechanical properties, which along with its biodegradable nature makes it an easy choice for its implication for material-based applications.

However, these structural peculiarities of cellulose also make it less reactive to chemicals; therefore, the ability to achieve a high degree of functionalization on cellulose is still limited and represents a challenge in the scientific community. Various cellulosic forms have been explored and found commercial success, including cellulose acetate, carboxymethyl cellulose, cellulose triacetate, cellulose sulfate, cellulose phosphate, nitrocellulose, and others.

This Special Issue highlights new and emerging trends, recent developments, and applications of cellulose functionalization-based materials (e.g., hydrogels, drug delivery systems, biomaterials, or other applications). Therefore, this Special Issue calls for manuscripts on scientific advancements and applied research developments in the following areas.

Dr. Arvind Negi
Dr. Kavindra K. Kesari
Guest Editors

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Keywords

  • cellulose-based biomaterials
  • functionalized cellulose in the biomedical field
  • functionalized cellulose in drug delivery
  • sustainable development of cellulose functionalization
  • functionalized-cellulose-based biological support platforms
  • naturally-derived polysaccharides-based biomaterials

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Published Papers (1 paper)

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Research

13 pages, 4488 KiB  
Article
A Comparison of Hemostatic Activities of Zeolite-Based Formulary Finishes on Cotton Dressings
by J. Vincent Edwards, Nicolette T. Prevost and Michael Santiago Cintron
J. Funct. Biomater. 2023, 14(5), 255; https://doi.org/10.3390/jfb14050255 - 4 May 2023
Cited by 7 | Viewed by 1514
Abstract
The need for affordable effective prehospital hemostatic dressings to control hemorrhage has led to an increased interest in new dressing design approaches. Here we consider the separate components of fabric, fiber, and procoagulant nonexothermic zeolite-based formulations on design approaches to accelerated hemostasis. The [...] Read more.
The need for affordable effective prehospital hemostatic dressings to control hemorrhage has led to an increased interest in new dressing design approaches. Here we consider the separate components of fabric, fiber, and procoagulant nonexothermic zeolite-based formulations on design approaches to accelerated hemostasis. The design of the fabric formulations was based on incorporation of zeolite Y as the principal procoagulant, with calcium and pectin to adhere and enhance the activity. Unbleached nonwoven cotton when combined with bleached cotton displays enhanced properties related to hemostasis. Here, we compare sodium zeolite with ammonium zeolite formulated on fabrics utilizing pectin with pad versus spray-dry-cure and varied fiber compositions. Notably, ammonium as a counterion resulted in shorter times to fibrin and clot formation comparable to the procoagulant standard. The time to fibrin formation as measured by thromboelastography was found to be within a range consistent with modulating severe hemorrhage control. The results indicate a correlation between fabric add-on and accelerated clotting as measured by both time to fibrin and clot formation. A comparison between the time to fibrin formation in calcium/pectin formulations and pectin alone revealed an enhanced clotting effect with calcium decreasing by one minute the time to fibrin formation. Infra-red spectra were employed to characterize and quantify the zeolite formulations on the dressings. Full article
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