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Journal of Functional Biomaterials, Volume 15, Issue 7

2024 July - 33 articles

Cover Story: Despite the recent advances in developing medical implants to support the healing of bone fractures, their optimal treatment has not yet been found. Magnesium and its alloys are potential candidates for filling this gap to increase therapeutic success. The mechanistic interaction of magnesium implant degradation and bone tissue remodeling is not yet fully understood, and it represents a barrier for leveraging the full potential of this material class. Our research shows that the bone tissue surrounding magnesium-based alloys and titanium implants differs in maturity and mechanical properties. Moreover, we observed the incorporation of magnesium into the crystal structure of the bones. View this paper
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Articles (33)

  • Article
  • Open Access
6 Citations
4,237 Views
41 Pages

Bioactive Hydrogel Formulation Based on Ferulic Acid-Grafted Nano-Chitosan and Bacterial Nanocellulose Enriched with Selenium Nanoparticles from Kombucha Fermentation

  • Naomi Tritean,
  • Luminița Dimitriu,
  • Ștefan-Ovidiu Dima,
  • Marius Ghiurea,
  • Bogdan Trică,
  • Cristian-Andi Nicolae,
  • Ionuț Moraru,
  • Alina Nicolescu,
  • Anisoara Cimpean and
  • Diana Constantinescu-Aruxandei
  • + 1 author

Selenium nanoparticles (SeNPs) have specific properties that result from their biosynthesis particularities. Chitosan can prevent pathogenic biofilm development. A wide palette of bacterial nanocellulose (BNC) biological and physical-chemical propert...

  • Article
  • Open Access
2 Citations
3,653 Views
15 Pages

Background: The aim of this study was to evaluate the biocompatibility and effectiveness in terms of osseointegration of dental implants composed of novel injectable bone grafts with and without ostrich eggshell particles and membrane protein in rabb...

  • Article
  • Open Access
2 Citations
3,117 Views
17 Pages

The objective of this study was to explore the effects of cold atmospheric plasma (CAP) treatment on the biological behavior of human gingival fibroblasts (HGFs) cultured on the surface of high-transparency zirconia. Two types of zirconia, 3Y-ZTP and...

  • Article
  • Open Access
5 Citations
2,510 Views
14 Pages

The Influence of Cement Thickness within the Cap on Stress Distribution for Dental Implants

  • Mario Ceddia,
  • Tea Romasco,
  • Luca Comuzzi,
  • Alessandro Cipollina,
  • Adriano Piattelli,
  • Gianna Dipalma,
  • Angelo Michele Inchingolo,
  • Francesco Inchingolo,
  • Natalia Di Pietro and
  • Bartolomeo Trentadue

The purpose of this finite element analysis (FEA) was to evaluate the stress distribution within the prosthetic components and bone in relation to varying cement thicknesses (from 20 to 60 μm) utilized to attach a zirconia crown on a conometric ca...

  • Article
  • Open Access
4 Citations
3,592 Views
10 Pages

The Antibacterial Properties of a Reinforced Zinc Oxide Eugenol Combined with Cloisite 5A Nanoclay: An In-Vitro Study

  • Bahareh Nazemisalman,
  • Shaghayegh Niaz,
  • Shayan Darvish,
  • Ayda Notash,
  • Ali Ramazani and
  • Ionut Luchian

Pulpotomies and pulpectomies are the most common clinical approach for dental caries in the primary dentition. Reinforced zinc oxide eugenol (ZOE) is an ideal material for filling in the pulp chamber after pulp therapies. The aim of this study was to...

  • Review
  • Open Access
6 Citations
3,198 Views
17 Pages

Electric Current Application on Dental Implant Biofilms: Review

  • Flávio Rodrigues,
  • Mariana Rodrigues da Silva,
  • Filipe S. Silva,
  • Sara Madeira and
  • Óscar Carvalho

The prevalence of complications due to the presence of biofilms in dental implant surfaces and their relationship with peri-implant diseases, namely peri-implantitis, remain difficult problems to overcome. The information available about the applicat...

  • Article
  • Open Access
3 Citations
1,924 Views
16 Pages

Despite years of extensive research, achieving the optimal properties for calcium phosphate-based biomaterials remains an ongoing challenge. Recently, ‘biomicroconcretes’ systems consisting of setting-phase-forming bone cement matrix and...

  • Article
  • Open Access
17 Citations
4,464 Views
16 Pages

Antibacterial Size Effect of ZnO Nanoparticles and Their Role as Additives in Emulsion Waterborne Paint

  • Imroi El-Habib,
  • Hassan Maatouk,
  • Alex Lemarchand,
  • Sarah Dine,
  • Anne Roynette,
  • Christine Mielcarek,
  • Mamadou Traoré and
  • Rabah Azouani

Nosocomial infections, a prevalent issue in intensive care units due to antibiotic overuse, could potentially be addressed by metal oxide nanoparticles (NPs). However, there is still no comprehensive understanding of the impact of NPs’ size on...

  • Review
  • Open Access
19 Citations
5,056 Views
24 Pages

Antibiotic-Loaded Nano-Sized Delivery Systems: An Insight into Gentamicin and Vancomycin

  • Silvia Pisani,
  • Shafia Tufail,
  • Mariella Rosalia,
  • Rossella Dorati,
  • Ida Genta,
  • Enrica Chiesa and
  • Bice Conti

The fight against infectious disease has remained an ever-evolving challenge in the landscape of healthcare. The ability of pathogens to develop resistance against conventional drug treatments has decreased the effectiveness of therapeutic interventi...

  • Article
  • Open Access
2 Citations
4,683 Views
18 Pages

Enhancing the Physical, Antimicrobial, and Osteo/Odontogenic Properties of a Sol–Gel-Derived Tricalcium Silicate by Graphene Oxide for Vital Pulp Therapies

  • Mohamed Mahmoud Abdalla,
  • Mohammed Zahedul Islam Nizami,
  • Vidhyashree Rajasekar,
  • Mohammed Basabrain,
  • Christie Y. K. Lung and
  • Cynthia Kar Yung Yiu

Objectives: This study developed a sol–gel tricalcium silicate/graphene oxide (TCS-GO) composite and examined its physicochemical properties, antimicrobial activity, and osteo/odontogenic effect on dental pulp stem cells. Methods: Tricalcium si...

  • Article
  • Open Access
3 Citations
2,251 Views
17 Pages

Sheep Bone Ultrastructure Analyses Reveal Differences in Bone Maturation around Mg-Based and Ti Implants

  • Kamila Iskhakova,
  • D. C. Florian Wieland,
  • Romy Marek,
  • Uwe Y. Schwarze,
  • Anton Davydok,
  • Hanna Cwieka,
  • Tamadur AlBaraghtheh,
  • Jan Reimers,
  • Birte Hindenlang and
  • Berit Zeller-Plumhoff
  • + 3 authors

Magnesium alloys are some of the most convenient biodegradable materials for bone fracture treatment due to their tailorable degradation rate, biocompatibility, and mechanical properties resembling those of bone. Despite the fact that magnesium-based...

  • Article
  • Open Access
5 Citations
2,223 Views
19 Pages

Antibacterial Effect of Silver Nanoparticles against Oral Biofilms in Subjects with Motor and Intellectual Disabilities

  • Carolina Holguín-Meráz,
  • Rita Elizabeth Martínez-Martínez,
  • Erasto Armando Zaragoza-Contreras,
  • Rubén Abraham Domínguez-Pérez,
  • Simón Yobanny Reyes-López,
  • Alejandro Donohue-Cornejo,
  • Juan Carlos Cuevas-González,
  • Erika de Lourdes Silva-Benítez,
  • Nelly Molina-Frechero and
  • León Francisco Espinosa-Cristóbal

Background: Motor and intellectual disabilities (MIDs) represent a great challenge for maintaining general health due to physical and cognitive limitations, particularly in the maintenance and preservation of oral health. Silver nanoparticles (AgNPs)...

  • Review
  • Open Access
3 Citations
1,747 Views
14 Pages

In the vast field of medical scientific research, few topics have managed to attract as much attention and mobilise academic resources as the use of dermal matrices in the reconstruction of soft tissue defects. In this study, we used bibliographic me...

  • Article
  • Open Access
4 Citations
3,164 Views
15 Pages

Electrophoretic Deposition of Chitosan Coatings on the Porous Titanium Substrate

  • Julia Flesińska,
  • Magdalena Szklarska,
  • Izabela Matuła,
  • Adrian Barylski,
  • Sylwia Golba,
  • Julia Zając,
  • Maciej Gawlikowski,
  • Przemysław Kurtyka,
  • Barbara Ilnicka and
  • Grzegorz Dercz

Medicine is looking for solutions to help implant patients recover more smoothly. The porous implants promote osteointegration, thereby providing better stabilization. Introducing porosity into metallic implants enhances their biocompatibility and fa...

  • Review
  • Open Access
5 Citations
3,714 Views
17 Pages

Current Advances in Nanomaterials Affecting Functions and Morphology of Platelets

  • Dongxin Peng,
  • Sujing Sun,
  • Man Zhao,
  • Linsheng Zhan and
  • Xiaohui Wang

Nanomaterials have been extensively used in the biomedical field due to their unique physical and chemical properties. They promise wide applications in the diagnosis, prevention, and treatment of diseases. Nanodrugs are generally transported to targ...

  • Article
  • Open Access
1 Citations
2,983 Views
15 Pages

Calcium silicate (CaSi) bone cement with antibacterial and osteogenic properties has attracted significant interest. However, there is a need to develop a variety of new premixed bone cement to meet the clinical requirements of fast setting time, eas...

  • Article
  • Open Access
15 Citations
3,126 Views
15 Pages

Background: This study investigated the biocompatibility and antibacterial efficacy of chitosan–gelatin (CH-G) scaffolds loaded with slow-releasing antibiotic formulations used in regeneration endodontic procedures (REPs). Methods: Scaffolds we...

  • Article
  • Open Access
2 Citations
1,941 Views
17 Pages

In this work, a new type of FE-1 COF material is prepared by a reversible imine condensation reaction with diaminoferrocene and diaminodiformaldehyde as materials. The material is connected by imine bonds to form a COF skeleton, and the presence of p...

  • Article
  • Open Access
5 Citations
5,277 Views
13 Pages

Cytotoxicity, Biocompatibility, and Calcium Deposition Capacity of 45S5 Bioglass Experimental Paste and Bio-C Temp: In Vitro and In Vivo Study Using Wistar Rats

  • Francine Benetti,
  • Pedro Henrique Chaves de Oliveira,
  • Maria Paula Bernal de Andrade,
  • Cristiane Cantiga-Silva,
  • Gustavo Sivieri-Araújo,
  • Eloi Dezan Júnior,
  • João Eduardo Gomes-Filho,
  • Ivana Márcia Alvez Diniz,
  • Alexandre Henrique dos Reis-Prado and
  • Luciano Tavares Angelo Cintra
  • + 2 authors

The evolution of biomaterials engineering allowed for the development of products that improve outcomes in the medical–dental field. Bioglasses have demonstrated the ability to either compose or replace different materials in dentistry. This st...

  • Article
  • Open Access
12 Citations
4,147 Views
22 Pages

Alginate-Sr/Mg Containing Bioactive Glass Scaffolds: The Characterization of a New 3D Composite for Bone Tissue Engineering

  • Benedetta Guagnini,
  • Barbara Medagli,
  • Bianca Zumbo,
  • Valeria Cannillo,
  • Gianluca Turco,
  • Davide Porrelli and
  • Devis Bellucci

In bone regeneration, combining natural polymer-based scaffolds with Bioactive Glasses (BGs) is an attractive strategy to improve the mechanical properties of the structure, as well as its bioactivity and regenerative potential. Methods: For this pur...

  • Article
  • Open Access
2 Citations
2,969 Views
24 Pages

Comparative Analysis of Osteointegration in Hydroxyapatite and Hydroxyapatite-Titanium Implants: An In Vivo Rabbit Model Study

  • Renata Maria Văruț,
  • Luciana Teodora Rotaru,
  • Flavius Nicușor Truicu,
  • Cristina Elena Singer,
  • Iliescu Iulian-Nicolae,
  • Alin Iulian Silviu Popescu,
  • Cristina Popescu,
  • Cristina Teisanu,
  • Gabriela Sima and
  • Oana Elena Nicolaescu

The study evaluates the osteointegration of hydroxyapatite (HAp) and hydroxyapatite-titanium (HApTi) biocomposites implanted in the femurs of rabbits. The biocomposites were fabricated using powder metallurgy and subjected to a two-step sintering pro...

  • Article
  • Open Access
3 Citations
1,809 Views
22 Pages

Anodic Production and Characterization of Biomimetic Oxide Layers on Grade 4 Titanium for Medical Applications

  • Delfina Nowińska,
  • Patrycja Osak,
  • Joanna Maszybrocka and
  • Bożena Łosiewicz

Biomaterials are the basis for the development of medicine because they allow safe contact with a living organism. The aim of this work was to produce innovative oxide layers with a microporous structure on the surface of commercially pure titanium G...

  • Article
  • Open Access
3 Citations
6,154 Views
12 Pages

Cytocompatibility of Polymers for Skin-Contact Applications Produced via Pellet Extrusion

  • Sakine Deniz Varsavas,
  • Paweł Michalec,
  • Mohammed Khalifa,
  • Ping Li and
  • Sebastian Spintzyk

Orthoses and prostheses (O&P) play crucial roles in assisting individuals with limb deformities or amputations. Proper material selection for these devices is imperative to ensure mechanical robustness and biocompatibility. While traditional manu...

  • Systematic Review
  • Open Access
37 Citations
5,123 Views
26 Pages

The Incorporation of Zinc into Hydroxyapatite and Its Influence on the Cellular Response to Biomaterials: A Systematic Review

  • Jessica Dornelas,
  • Giselle Dornelas,
  • Alexandre Rossi,
  • Adriano Piattelli,
  • Natalia Di Pietro,
  • Tea Romasco,
  • Carlos Fernando Mourão and
  • Gutemberg Gomes Alves

Zinc is known for its role in enhancing bone metabolism, cell proliferation, and tissue regeneration. Several studies proposed the incorporation of zinc into hydroxyapatite (HA) to produce biomaterials (ZnHA) that stimulate and accelerate bone healin...

  • Article
  • Open Access
15 Citations
6,641 Views
11 Pages

Mechanical Behavior of Five Different Morse Taper Implants and Abutments with Different Conical Internal Connections and Angles: An In Vitro Experimental Study

  • Claudia Caballero,
  • Fernando Rodriguez,
  • Guillermo Castro Cortellari,
  • Antonio Scarano,
  • Juan Carlos Prados-Frutos,
  • Piedad N. De Aza,
  • Gustavo Vicentis Oliveira Fernandes and
  • Sergio Alexandre Gehrke

The present study evaluated the mechanical behavior of five designs of Morse taper (MT) connections with and without the application of loads. For this, the detorque of the fixing screw and the traction force required to disconnect the abutment from...

  • Article
  • Open Access
3 Citations
2,084 Views
16 Pages

The need for a long-term solution for filling the defects created during partial mastectomies due to breast cancer diagnosis has not been met to date. All available defect-filling methods are non-permanent and necessitate repeat procedures. Here, we...

  • Review
  • Open Access
18 Citations
5,394 Views
22 Pages

Oral and Extra-Oral Manifestations of Hypersensitivity Reactions in Orthodontics: A Comprehensive Review

  • Federica Di Spirito,
  • Alessandra Amato,
  • Maria Pia Di Palo,
  • Rahila Ferraro,
  • Davide Cannatà,
  • Marzio Galdi,
  • Elettra Sacco and
  • Massimo Amato

Although rare, oral manifestations of hypersensitivity reactions in orthodontic patients pose a significant clinical challenge due to their heterogeneous presentations, and can cause discomfort and pain, possibly impacting patients’ quality of...

  • Article
  • Open Access
2 Citations
2,093 Views
13 Pages

Optimizing Filament-Based TCP Scaffold Design for Osteoconduction and Bone Augmentation: Insights from In Vivo Rabbit Models

  • Julien Guerrero,
  • Ekaterina Maevskaia,
  • Chafik Ghayor,
  • Indranil Bhattacharya and
  • Franz E. Weber

Additive manufacturing has emerged as a transformative tool in biomedical engineering, offering precise control over scaffold design for bone tissue engineering and regenerative medicine. While much attention has been focused on optimizing pore-based...

  • Review
  • Open Access
59 Citations
13,554 Views
13 Pages

This review article will discuss the origin of resin-based dental composite materials and their adoption as potentially useful adjuncts to the primary material used by most dentists for direct restorations. The evolution of the materials, largely dri...

  • Review
  • Open Access
8 Citations
4,705 Views
23 Pages

Advances in Extraction, Structure, and Physiochemical Properties of Sorghum Kafirin for Biomaterial Applications: A Review

  • Umar Shah,
  • Rewati Bhattarai,
  • Hani Al-Salami,
  • Christopher Blanchard and
  • Stuart K. Johnson

Kafirin is an endosperm-specific hydrophobic protein found in sorghum grain and the waste by-product from sorghum biorefineries known as sorghum dried distillers’ grain with solubles (DDGS). Because of kafirin’s poor nutritional profile (...

  • Article
  • Open Access
1 Citations
1,970 Views
11 Pages

Fracture Resistance of Posterior Milled Nanoceramic Crowns after Thermomechanical Aging

  • Fajer Abdulaziz Alnajjar,
  • Arwa Jamal Alloughani,
  • Mohammed Nasser Alhajj and
  • Mirza Rustum Baig

Fracture resistance is an important parameter used to predict the performance of indirect dental restorations. The purpose of this in vitro study was to assess the fracture load of posterior milled nanoceramic crowns, in comparison with the lithium d...

  • Article
  • Open Access
1 Citations
1,788 Views
15 Pages

Preliminary Evaluation of Bioactive Collagen–Polyphenol Surface Nanolayers on Titanium Implants: An X-ray Photoelectron Spectroscopy and Bone Implant Study

  • Marco Morra,
  • Giorgio Iviglia,
  • Clara Cassinelli,
  • Maria Sartori,
  • Luca Cavazza,
  • Lucia Martini,
  • Milena Fini and
  • Gianluca Giavaresi

To endow an implant surface with enhanced properties to ensure an appropriate seal with the host tissue for inflammation/infection resistance, next-generation bone implant collagen–polyphenol nanolayers were built on conventional titanium surfa...

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J. Funct. Biomater. - ISSN 2079-4983