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Biomaterials for Soft and Hard Tissue Engineering
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Biomaterials for Soft and Hard Tissue Engineering

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983). This special issue belongs to the section "Biomaterials for Tissue Engineering and Regenerative Medicine".

Deadline for manuscript submissions: closed (10 July 2024) | Viewed by 29254

Special Issue Editors

Dr. Mansour Youseffi

E-Mail Website
Guest Editor
Faculty of Engineering and Digital Technologies, School of Engineering, University of Bradford, Bradford BD7 1DP, UK
Interests: artificial intelligence; medical diagnostics; medical electronics
Special Issues, Collections and Topics in MDPI journals
Dr. Farshid Sefat

E-Mail Website
Guest Editor
Faculty of Engineering and Informatics, Biomedical and Electronics Engineering Department, University of Bradford, Bradford BD7 1DP, UK
Interests: biomaterials design; processing; testing and development; cell and tissue engineering; electrospinning
Special Issues, Collections and Topics in MDPI journals
Dr. Morvarid Saeinasab

E-Mail Website
Guest Editor
Faculty of Engineering and Informatics, Biomedical and Electronics Engineering Department, University of Bradford, Bradford BD7 1DP, UK
Interests: biology; stem cells; biomaterials design; biological testing; regenerative medicine; cell and tissue engineering

Special Issue Information

Dear Colleagues,

This Special Issue focuses on biomaterials for soft and hard tissue engineering. This Special Issue provides an opportunity to submit comprehensive reviews and research articles on recent advancements in the application and use of various scaffolds and biomaterials in tissue engineering. Manuscripts will focus on both soft and hard tissues/organs, the materials used for treatment and repair, natural composite scaffolds, synthetic biomaterials, fabrication techniques, innovative materials and approaches for scaffold preparation, host response to the scaffolds, challenges and future perspectives. Bringing all the information together in one major reference, authors will systematically review and summarize recent research findings, thus providing an in-depth understanding of the scaffolds used in different body parts.

Dr. Mansour Youseffi
Dr. Farshid Sefat
Dr. Morvarid Saeinasab
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomaterials
  • hard tissue
  • soft tissue
  • regenerative medicine
  • scaffold
  • synthetic
  • natural biomaterials
  • biocomposites

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Further information on MDPI's Special Issue polices can be found here.

Published Papers (4 papers)

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Research

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22 pages, 7533 KiB  
Article
Tilapia Fish Skin Treatment of Third-Degree Skin Burns in Murine Model
by Carissa Garrity, Christina Garcia-Rovetta, Iris Rivas, Ubaldo Delatorre, Alice Wong, Dietmar Kültz, Jamie Peyton, Boaz Arzi and Natalia Vapniarsky
J. Funct. Biomater. 2023, 14(10), 512; https://doi.org/10.3390/jfb14100512 - 11 Oct 2023
Cited by 2 | Viewed by 20556
Abstract
This study explored the feasibility of using fish skin bandages as a therapeutic option for third-degree skin burns. Following the California wildfires, clinical observations of animals with third-degree skin burns demonstrated increased comfort levels and reduced pain when treated with tilapia fish skin. [...] Read more.
This study explored the feasibility of using fish skin bandages as a therapeutic option for third-degree skin burns. Following the California wildfires, clinical observations of animals with third-degree skin burns demonstrated increased comfort levels and reduced pain when treated with tilapia fish skin. Despite the promises of this therapy, there are few studies explaining the healing mechanisms behind the application of tilapia fish skin. In this study, mice with third-degree burns were treated with either a hydrocolloid adhesive bandage (control) (n = 16) or fish skin (n = 16) 7 days post-burn. Mice were subjected to histologic, hematologic, molecular, and gross evaluation at days 7, 16, and 28 post-burn. The fish skin offered no benefit to overall wound closure compared to hydrocolloids. Additionally, we detected no difference between fish skin and control treatments in regard to hypermetabolism or hematologic values. However, the fish skin groups exhibited 2 times more vascularization and 2 times higher expression of antimicrobial defensin peptide in comparison to controls. Proteomic analysis of the fish skin revealed the presence of antimicrobial peptides. Collectively, these data suggest that fish skin can serve as an innovative and cost-effective therapeutic alternative for burn victims to facilitate vascularization and reduce bacterial infection. Full article
(This article belongs to the Special Issue Biomaterials for Soft and Hard Tissue Engineering)
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18 pages, 7464 KiB  
Article
Efficacy of Pegylated Hyaluronic Acid Filler Enriched with Calcium Hydroxyapatite: A 24-Week Post-Market, Observational, Prospective, Open-Label, Single-Center Study
by Nicola Zerbinati, Edoardo D’Este, Annalisa De Silvestri, Marco Zullino, Giulio Rabbiosi, Stefania Guida, Paweł Kubik, Giorgio Stabile, Roberto Mocchi, Chiara Barlusconi, Sabrina Sommatis and Giovanna Cipolla
J. Funct. Biomater. 2023, 14(7), 345; https://doi.org/10.3390/jfb14070345 - 29 Jun 2023
Viewed by 2966
Abstract
Recently, thanks to the greater discovery of the mechanisms of facial aging, an alternative to invasive plastic surgery has found space with less invasive aesthetic procedures, also based on an increasingly pressing request. We are specifically referring to dermal filler injection into or [...] Read more.
Recently, thanks to the greater discovery of the mechanisms of facial aging, an alternative to invasive plastic surgery has found space with less invasive aesthetic procedures, also based on an increasingly pressing request. We are specifically referring to dermal filler injection into or under the skin which leads to immediate rejuvenation and aesthetic improvements. In this study, we wanted to analyze the results obtained through the use of NEAUVIA Organic Stimulate, particularly with regard to its effectiveness, which is a cross-linked polymeric hydrogel, containing stabilized sodium hyaluronate 26 mg/mL and calcium hydroxyapatite (1%), glycine and L-proline in buffer pyrogen-free water, in its main indication, namely, the temporary correction of congenital and acquired deficiencies of the soft tissues of the face by intradermal injection. Initially, 70 patients were enrolled, but 10 did not complete the study due to non-observance of the investigation rules, so they were excluded from the protocol. The collected data demonstrate an efficient mechanical effect of the pegylated polymeric acid matrix enriched with low concertation of calcium hydroxyapatite and in accordance with other evidence in vitro and in vivo, and the mechanical support of the interstitial connective space improves the homestays of the anatomical layer rebalancing the physiological activity of the dermis cells. Full article
(This article belongs to the Special Issue Biomaterials for Soft and Hard Tissue Engineering)
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19 pages, 2643 KiB  
Article
Reinforcement of Hydrogels with a 3D-Printed Polycaprolactone (PCL) Structure Enhances Cell Numbers and Cartilage ECM Production under Compression
by Hamed Alizadeh Sardroud, Xiongbiao Chen and B. Frank Eames
J. Funct. Biomater. 2023, 14(6), 313; https://doi.org/10.3390/jfb14060313 - 7 Jun 2023
Cited by 4 | Viewed by 2143
Abstract
Hydrogels show promise in cartilage tissue engineering (CTE) by supporting chondrocytes and maintaining their phenotype and extracellular matrix (ECM) production. Under prolonged mechanical forces, however, hydrogels can be structurally unstable, leading to cell and ECM loss. Furthermore, long periods of mechanical loading might [...] Read more.
Hydrogels show promise in cartilage tissue engineering (CTE) by supporting chondrocytes and maintaining their phenotype and extracellular matrix (ECM) production. Under prolonged mechanical forces, however, hydrogels can be structurally unstable, leading to cell and ECM loss. Furthermore, long periods of mechanical loading might alter the production of cartilage ECM molecules, including glycosaminoglycans (GAGs) and collagen type 2 (Col2), specifically with the negative effect of stimulating fibrocartilage, typified by collagen type 1 (Col1) secretion. Reinforcing hydrogels with 3D-printed Polycaprolactone (PCL) structures offer a solution to enhance the structural integrity and mechanical response of impregnated chondrocytes. This study aimed to assess the impact of compression duration and PCL reinforcement on the performance of chondrocytes impregnated with hydrogel. Results showed that shorter loading periods did not significantly affect cell numbers and ECM production in 3D-bioprinted hydrogels, but longer periods tended to reduce cell numbers and ECM compared to unloaded conditions. PCL reinforcement enhanced cell numbers under mechanical compression compared to unreinforced hydrogels. However, the reinforced constructs seemed to produce more fibrocartilage-like, Col1-positive ECM. These findings suggest that reinforced hydrogel constructs hold potential for in vivo cartilage regeneration and defect treatment by retaining higher cell numbers and ECM content. To further enhance hyaline cartilage ECM formation, future studies should focus on adjusting the mechanical properties of reinforced constructs and exploring mechanotransduction pathways. Full article
(This article belongs to the Special Issue Biomaterials for Soft and Hard Tissue Engineering)
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Review

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31 pages, 4498 KiB  
Review
A Review on Electroactive Polymer–Metal Composites: Development and Applications for Tissue Regeneration
by Rumi Acharya, Sayan Deb Dutta, Tejal V. Patil, Keya Ganguly, Aayushi Randhawa and Ki-Taek Lim
J. Funct. Biomater. 2023, 14(10), 523; https://doi.org/10.3390/jfb14100523 - 17 Oct 2023
Cited by 5 | Viewed by 2712
Abstract
Electroactive polymer–metal composites (EAPMCs) have gained significant attention in tissue engineering owing to their exceptional mechanical and electrical properties. EAPMCs develop by combining an electroactive polymer matrix and a conductive metal. The design considerations include choosing an appropriate metal that provides mechanical strength [...] Read more.
Electroactive polymer–metal composites (EAPMCs) have gained significant attention in tissue engineering owing to their exceptional mechanical and electrical properties. EAPMCs develop by combining an electroactive polymer matrix and a conductive metal. The design considerations include choosing an appropriate metal that provides mechanical strength and electrical conductivity and selecting an electroactive polymer that displays biocompatibility and electrical responsiveness. Interface engineering and surface modification techniques are also crucial for enhancing the adhesion and biocompatibility of composites. The potential of EAPMC-based tissue engineering revolves around its ability to promote cellular responses, such as cell adhesion, proliferation, and differentiation, through electrical stimulation. The electrical properties of these composites can be used to mimic natural electrical signals within tissues and organs, thereby aiding tissue regeneration. Furthermore, the mechanical characteristics of the metallic components provide structural reinforcement and can be modified to align with the distinct demands of various tissues. EAPMCs have extraordinary potential as regenerative biomaterials owing to their ability to promote beneficial effects in numerous electrically responsive cells. This study emphasizes the characteristics and applications of EAPMCs in tissue engineering. Full article
(This article belongs to the Special Issue Biomaterials for Soft and Hard Tissue Engineering)
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