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Antibacterial Biomaterials for Medical Applications
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Antibacterial Biomaterials for Medical Applications

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983). This special issue belongs to the section "Antibacterial Biomaterials".

Deadline for manuscript submissions: 20 December 2024 | Viewed by 2381

Special Issue Editors

Dr. Min Zhou

E-Mail Website
Guest Editor
School of Materials Science and Engineering, East China University of Science and Technology, Shanghai, China
Interests: antimicrobial polymers; peptide-mimicking polymers; poly(2-oxazoline)s; poly(amino acid)s; drug-resistant microbes
Dr. Yueming Wu

E-Mail Website
Guest Editor
School of Materials Science and Engineering, East China University of Science and Technology, Shanghai, China
Interests: antimicrobial polymers; poly(amino acid)s; antibacterial peptide materials; polymerization method on NCA; tissue engineering

Special Issue Information

Dear Colleagues,

Microbial infection poses a great threat to human health. Over the past century, antibiotic therapy has played a crucial role in antimicrobial treatment. However, the overuse of antibiotics has led to the emergence and spread of antibiotic-resistant microbes, posing a great challenge to clinical treatment. Therefore, it is crucial to develop novel antimicrobial biomaterials with potent antimicrobial activity and biosafety against antibiotic-resistant microbes and novel technologies and strategies to address the challenge of drug-resistant microorganisms. The aim of this Special Issue is to discuss the advances and applications of antimicrobial biomaterials, including, but not limited to, addressing microbial infections, bacterial biofilm infections, antibiotic resistance, and the biosafety of antimicrobial drugs. Topics of interest include the following:

  • Perspectives for addressing microbe-associated infections and biofilm infections;
  • Novel technologies and strategies to mitigate microbial resistance;
  • Infection models investigating biomaterial interactions;
  • Microbial response to the surfaces of implantable materials and medical devices;
  • Antibacterial and antifungal peptides and the related polymeric materials;
  • Antimicrobial nanotechnology applied to medical materials;
  • New antimicrobial strategies, including drug combination, drug-delivery, and drug modification;
  • Antibacterial stewardship on biomaterial design and development;
  • Polymerization method for synthetic antimicrobial polymers.

Research and review articles on antimicrobial biomaterials for medical applications are welcome. We look forward to receiving your valuable contributions.

Dr. Min Zhou
Dr. Yueming Wu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • microbe infections
  • biofilm infections
  • antimicrobial peptides
  • antimicrobial biomaterials
  • antibiotic resistance
  • antimicrobial nanotechnology
  • antimicrobial surface
  • drug combination
  • polymerization method

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Further information on MDPI's Special Issue polices can be found here.

Published Papers (2 papers)

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Research

19 pages, 8076 KiB  
Article
Antibacterial Effect of Silver Nanoparticles against Oral Biofilms in Subjects with Motor and Intellectual Disabilities
by Carolina Holguín-Meráz, Rita Elizabeth Martínez-Martínez, Erasto Armando Zaragoza-Contreras, Rubén Abraham Domínguez-Pérez, Simón Yobanny Reyes-López, Alejandro Donohue-Cornejo, Juan Carlos Cuevas-González, Erika de Lourdes Silva-Benítez, Nelly Molina-Frechero and León Francisco Espinosa-Cristóbal
J. Funct. Biomater. 2024, 15(7), 191; https://doi.org/10.3390/jfb15070191 - 10 Jul 2024
Cited by 1 | Viewed by 794
Abstract
Background: Motor and intellectual disabilities (MIDs) represent a great challenge for maintaining general health due to physical and cognitive limitations, particularly in the maintenance and preservation of oral health. Silver nanoparticles (AgNPs) have emerged as a promising therapeutic tool for bacterial control, including [...] Read more.
Background: Motor and intellectual disabilities (MIDs) represent a great challenge for maintaining general health due to physical and cognitive limitations, particularly in the maintenance and preservation of oral health. Silver nanoparticles (AgNPs) have emerged as a promising therapeutic tool for bacterial control, including oral biofilms; however, knowledge of the bactericidal effectiveness of oral biofilms from patients with MIDs is insufficient. This study aims to determine the antimicrobial effect of AgNPs on different oral biofilms taken from patients with and without MIDs. Methods: Two sizes of AgNPs were prepared and characterized by dynamic light scattering (DLS) and transmission electron microscopy (TEM). Through consecutive sampling, biofilm samples were collected from 17 subjects with MIDs and 20 subjects without disorders. The antimicrobial effect was determined by obtaining the minimum inhibitory concentration (MIC) of AgNPs, and the identification and distribution of oral bacterial species were determined by polymerase chain reaction (PCR). Finally, correlations between sociodemographic characteristics and the antimicrobial levels of AgNPs were also explored. The values of the MIC results were analyzed with IBM-SPSS software (version25) using non-parametric tests for independent groups and correlations, with statistical significance being considered as p < 0.05. Results: Both sizes of AgNPs exhibited tight particle size distributions (smaller: 10.2 ± 0.7 nm; larger: 29.3 ± 2.3 nm) with zeta potential values (−35.0 ± 3.3 and −52.6 ± 8.5 mV, respectively) confirming the stability that resulted in little to no agglomeration of nanoparticles. Although both sizes of AgNPs had good antimicrobial activity in all oral biofilms, the smallest particles had the best antimicrobial effects on the oral biofilm samples from patients with and without MIDs, even better than chlorhexidine (CHX) (p < 0.05). Likewise, the patients with disabilities showed higher levels of antimicrobial sensitivity to AgNPs compared with CHX (p < 0.05). Although the microorganisms included in the biofilms of females had a statistically higher growth level, the AgNP antimicrobial effect was statistically similar in both genders (p > 0.05). The most frequent bacteria for all oral biofilms were S. mutans (100%), P. intermedia (91.6%), T. forsythia (75.0%), T. denticola (75.0%), P. gingivalis (66.6%), F. nucleatum (66.6%), S. sobrinus (50.0%), and A. actinomycetemcomitans (8.3%). Conclusions: AgNPs exhibited considerable antimicrobial potential to be used as a complementary and alternative tool in maintaining and preserving oral health in patients with MIDs. Full article
(This article belongs to the Special Issue Antibacterial Biomaterials for Medical Applications)
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15 pages, 5346 KiB  
Article
Synergistic Effect of Polyethylene Glycol and Lactic Acid on Handling Properties and Antibacterial Efficacy of Premixed Calcium Silicate Cement
by Yi-Huei Huang, I-Ting Wu, Chun-Cheng Chen and Shinn-Jyh Ding
J. Funct. Biomater. 2024, 15(7), 187; https://doi.org/10.3390/jfb15070187 - 5 Jul 2024
Viewed by 1353
Abstract
Calcium silicate (CaSi) bone cement with antibacterial and osteogenic properties has attracted significant interest. However, there is a need to develop a variety of new premixed bone cement to meet the clinical requirements of fast setting time, ease of handling, and efficient antibacterial [...] Read more.
Calcium silicate (CaSi) bone cement with antibacterial and osteogenic properties has attracted significant interest. However, there is a need to develop a variety of new premixed bone cement to meet the clinical requirements of fast setting time, ease of handling, and efficient antibacterial properties. In this study, different volume ratios of polyethylene glycol (PEG) and lactic acid liquids were added to calcium silicate, and the effects of varying liquid-to-powder ratios (L/P) were examined. This study assessed the physicochemical properties, cytotoxicity, and antibacterial activity against S. aureus and E. coli of this premixed cement. The results from the experiments indicated that lactic acid significantly reduced the setting time of the CaSi-based cement and enhanced its mechanical strength. Furthermore, the appropriate concentration of lactic acid and matching L/P ratio improved its washout resistance. The cell viability of all premixed cement was found to be over 80%. The premixed cement containing PEG and lactic acid exhibited superior antibacterial properties compared to the CaSi control. Based on its setting time, washout resistance, and antibacterial activity, a premixed cement with a liquid phase of 80% PEG and 20% lactic acid at an L/P ratio of 0.4 appeared promising for use in dental and orthopedic practice. Full article
(This article belongs to the Special Issue Antibacterial Biomaterials for Medical Applications)
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