Functional and Protective Coatings for Implants and Tissue Engineering Formulations

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983). This special issue belongs to the section "Biomaterials for Tissue Engineering and Regenerative Medicine".

Deadline for manuscript submissions: closed (31 March 2024) | Viewed by 1147

Special Issue Editors


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Guest Editor
National Centre for Scientific Research “Demokritos”, Institute of Nanoscience and Nanotechnology, 15310 Athens, Greece
Interests: dendritic polymers; xerogels; water purification; liquid crystals; metal nanoparticle catalysts; antimicrobial coatings

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Guest Editor
Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain
Interests: biofilms; bacterial virulence; antimicrobial resistant; drug discovery
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Special Issue Information

Dear Colleagues,

The impressive multitude of implants and prosthetics along with their contribution to medicine and cosmetology are unquestionable. Despite the significant progress attained, there are still major complications. Adverse responses of the immune system to foreign substances,  microbial attacks, biofilm formation and overall stability and durability issues of the insets impede wider implementation. In order to address these problems, protract their functionality and avoid surgical operations as much as possible, a new branch for developing case-specific coatings has emerged.  In this framework, a wide variety of antibiofilm and protective layers has evolved. Furthermore, formulations that promote favourable interactions with the relevant cells and integration with the surrounding tissues are growingly produced. The latter may also operate as controlled release carriers or hosts of ingredients that are sensitive to temperature, pH and other critical factors. In this manner, they may create stimuli-sensitive surfaces and smart devices that induce important supplementary functionalities. The scope of this Special Issue is to provide a medium for the promotion of cutting-edge research in the field and the presentation of the already-achieved advancement in the form of reviews.

Dr. Michael Arkas
Dr. Sara M. Soto
Guest Editors

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Keywords

  • regenerative medicine
  • tissue engineering
  • antibiofilm
  • hydrogels
  • scaffolds
  • smart
  • osseointegration
  • implants
  • prosthetics

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Published Papers (1 paper)

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Research

41 pages, 11168 KiB  
Article
Bioactive Hydrogel Formulation Based on Ferulic Acid-Grafted Nano-Chitosan and Bacterial Nanocellulose Enriched with Selenium Nanoparticles from Kombucha Fermentation
by Naomi Tritean, Luminița Dimitriu, Ștefan-Ovidiu Dima, Marius Ghiurea, Bogdan Trică, Cristian-Andi Nicolae, Ionuț Moraru, Alina Nicolescu, Anisoara Cimpean, Florin Oancea and Diana Constantinescu-Aruxandei
J. Funct. Biomater. 2024, 15(7), 202; https://doi.org/10.3390/jfb15070202 - 22 Jul 2024
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Abstract
Selenium nanoparticles (SeNPs) have specific properties that result from their biosynthesis particularities. Chitosan can prevent pathogenic biofilm development. A wide palette of bacterial nanocellulose (BNC) biological and physical-chemical properties are known. The aim of this study was to develop a hydrogel formulation (SeBNCSFa) [...] Read more.
Selenium nanoparticles (SeNPs) have specific properties that result from their biosynthesis particularities. Chitosan can prevent pathogenic biofilm development. A wide palette of bacterial nanocellulose (BNC) biological and physical-chemical properties are known. The aim of this study was to develop a hydrogel formulation (SeBNCSFa) based on ferulic acid-grafted chitosan and bacterial nanocellulose (BNC) enriched with SeNPs from Kombucha fermentation (SeNPsK), which could be used as an adjuvant for oral implant integration and other applications. The grafted chitosan and SeBNCSFa were characterized by biochemical and physical-chemical methods. The cell viability and proliferation of HGF-1 gingival fibroblasts were investigated, as well as their in vitro antioxidant activity. The inflammatory response was determined by enzyme-linked immunosorbent assay (ELISA) of the proinflammatory mediators (IL-6, TNF-α, and IL-1β) in cell culture medium. Likewise, the amount of nitric oxide released was measured by the Griess reaction. The antimicrobial activity was also investigated. The grafting degree with ferulic acid was approximately 1.780 ± 0.07% of the total chitosan monomeric units, assuming single-site grafting per monomer. Fourier-transform infrared spectroscopy evidenced a convolution of BNC and grafted chitosan spectra, and X-ray diffraction analysis highlighted an amorphous rearrangement of the diffraction patterns, suggesting multiple interactions. The hydrogel showed a high degree of cytocompatibility, and enhanced antioxidant, anti-inflammatory, and antimicrobial potentials. Full article
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