Biomaterials in Bone Reconstruction

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983). This special issue belongs to the section "Bone Biomaterials".

Deadline for manuscript submissions: 20 November 2024 | Viewed by 489

Special Issue Editor


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Guest Editor
School of Electrical and Automation Engineering, Nanjing Normal University, Nanjing 210023, China
Interests: bioprinting; tissue engineering; flexible electronics

Special Issue Information

Dear colleagues,

This Special Issue aims to focus on the current status and recent advances in biomaterials for bone reconstruction. Natural bone is a complex tissue vital for structural support, organ protection and mobility. Bone defects, especially complicated or large-scale lesions resulting from tumors, trauma, infection or other damages, are still a challenging issue. To improve the reconstruction of the damaged bones, tissue engineering has been introduced as a promising approach. Artificial bone must have sufficient mechanical and excellent biological properties. Bioengineered composite scaffolds consisting of multifunctional biomaterials with cells, growth factors and bioactive therapeutic agents have great promise for bone reconstruction. Smart stimulus-responsive materials have recently been researched to facilitate non-invasive and controllable dynamic repair or bone defects with the help of electrical, optical, ultrasound and thermal stimuli related to external physical triggers or disease microenvironments. To mimic the original structure of bone tissue, gradient porous scaffold structures were designed in the lattice form, truss structures and triply periodic minimal surface structures. Additionally, three-dimensional (3D) printing technologies  allow for the specific fabrication of scaffolds with an appropriate size, shape and intrinsic structures. Considering the pivotal role of bone tissue, this Special Issue seeks innovative strategies to promote bone defect repair and regeneration.

Dr. Liya Zhu
Guest Editor

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Keywords

  • biomaterials
  • tissue engineering
  • porous scaffold
  • 3D printing
  • bone regeneration

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Published Papers (1 paper)

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Review

33 pages, 20993 KiB  
Review
Nanoparticles in Bone Regeneration: A Narrative Review of Current Advances and Future Directions in Tissue Engineering
by Samira Farjaminejad, Rosana Farjaminejad and Franklin Garcia-Godoy
J. Funct. Biomater. 2024, 15(9), 241; https://doi.org/10.3390/jfb15090241 - 23 Aug 2024
Viewed by 364
Abstract
The rising demand for effective bone regeneration has underscored the limitations of traditional methods like autografts and allografts, including donor site morbidity and insufficient biological signaling. This review examines nanoparticles (NPs) in tissue engineering (TE) to address these challenges, evaluating polymers, metals, ceramics, [...] Read more.
The rising demand for effective bone regeneration has underscored the limitations of traditional methods like autografts and allografts, including donor site morbidity and insufficient biological signaling. This review examines nanoparticles (NPs) in tissue engineering (TE) to address these challenges, evaluating polymers, metals, ceramics, and composites for their potential to enhance osteogenesis and angiogenesis by mimicking the extracellular matrix (ECM) nanostructure. The methods involved synthesizing and characterizing nanoparticle-based scaffoldsand integrating hydroxyapatite (HAp) with polymers to enhance mechanical properties and osteogenic potential. The results showed that these NPs significantly promote cell growth, differentiation, and bone formation, with carbon-based NPs like graphene and carbon nanotubes showing promise. NPs offer versatile, biocompatible, and customizable scaffolds that enhance drug delivery and support bone repair. Despite promising results, challenges with cytotoxicity, biodistribution, and immune responses remain. Addressing these issues through surface modifications and biocompatible molecules can improve the biocompatibility and efficacy of nanomaterials. Future research should focus on long-term in vivo studies to assess the safety and efficacy of NP-based scaffolds and explore synergistic effects with other bioactive molecules or growth factors. This review underscores the transformative potential of NPs in advancing BTE and calls for further research to optimize these technologies for clinical applications. Full article
(This article belongs to the Special Issue Biomaterials in Bone Reconstruction)
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