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Natural Product-Based Biomaterials for Advanced Wound Dressings
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Natural Product-Based Biomaterials for Advanced Wound Dressings

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983). This special issue belongs to the section "Biomaterials for Tissue Engineering and Regenerative Medicine".

Deadline for manuscript submissions: 20 December 2024 | Viewed by 2926

Special Issue Editors

Prof. Dr. Valeria Ambrogi

E-Mail Website
Guest Editor
Dipartimento di Scienze Farmaceutiche, University of Perugia, Perugia, Italy
Interests: drug delivery; dental materials; wound dressing; biomaterials for prevention and control of biofilms; mesoporous silica; hydroxyapatite
Prof. Maria Carla Marcotullio

E-Mail Website
Guest Editor
Department of Pharmaceutical Sciences, University of Perugia, Via del Liceo 1, 06123 Perugia, Italy
Interests: plant extract analysis; bioactive natural compounds; natural product isolation and characterization; NMR spectroscopy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The skin is the organ responsible for protecting the body from the outside and therefore performs a barrier function, which is lost if the skin is not intact. Wounds are defects or breaks in the skin due to various causes, such as physical, chemical, and thermal damage, and are divided into acute and chronic if they do not heal within 12 weeks. Nowadays, wounds not only resulting from pathologies, such as diabetes and obesity, but also those due to the aging of the population are increasing. Although there are new materials available nowadays compared to the past, an ideal dressing does not yet exist. Dressings are traditionally used to protect the wound, but they can also be used as a source of release of antimicrobial agents, bioactive molecules with anti-inflammatory, pain-relieving, and healing action, and smell-controlling agents. Having a local release of these active agents allows to avoid systemic administration with the risk of not reaching the minimum effective concentration on site and exposing the body to high doses of drugs. Also worth highlighting is the possibility of using alternative agents to antibiotics in view of the increase in bacterial resistance.

Natural products (NPs) are still a valuable source of bioactive molecules. Several studies have shown how NPs can promote wound healing, due to their anti-inflammatory, antioxidant, and antimicrobial activities. For these reasons, medicinal plants can be promising therapeutics for improving wound healing in different ways: as a source of bioactive compounds or drug-releasing biomaterials.

Therefore, this Special Issue aims at innovative studies on natural agent-based advanced wound dressings able to promote healing, preventing and reducing infections, and enhancing patient compliance, with attention to innovative drug delivery systems.

Prof. Dr. Valeria Ambrogi
Prof. Maria Carla Marcotullio
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomaterials
  • chronic wounds
  • wound healing
  • anti-inflammatory agents
  • antibiofilm activity
  • antimicrobial activity
  • anti-inflammatory activity
  • smell-controlling agents
  • natural products
  • tissue regeneration
  • topic drug delivery

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Published Papers (2 papers)

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Research

17 pages, 4057 KiB  
Article
Healing Potential of the Marine Polysaccharides Carrageenan and Ulvan on Second-Degree Burns
by Dimitra Statha, Asimina Papaioannou, Stefanos Kikionis, Maria Kostaki, Ioannis Sfiniadakis, Andreas Vitsos, Jane Anastassopoulou, Efstathia Ioannou, Vassilios Roussis and Michail Christou Rallis
J. Funct. Biomater. 2024, 15(9), 257; https://doi.org/10.3390/jfb15090257 - 5 Sep 2024
Viewed by 655
Abstract
The treatment of second-degree burn wounds presents a significant clinical challenge, often characterized by prolonged healing times and risk of complications. In this study, the wound healing potential of bioactive marine sulfated polysaccharides ulvan and carrageenan formulated in gels at concentrations of 1.5%, [...] Read more.
The treatment of second-degree burn wounds presents a significant clinical challenge, often characterized by prolonged healing times and risk of complications. In this study, the wound healing potential of bioactive marine sulfated polysaccharides ulvan and carrageenan formulated in gels at concentrations of 1.5%, 5.0%, and 10% w/w was evaluated. Hairless female SKH-hr2 mice (n = 7 per treatment) with burn-inflamed skin were treated with the polysaccharide-based gels, and the therapeutic efficacy was assessed using a comprehensive array of evaluation methods, including a histopathological analysis, clinical observation, photo-documentation, an image analysis, an evaluation of biophysical skin parameters, and FT-IR spectroscopy. Our findings indicate that the 10% w/w carrageenan gel exhibited significant enhancement in wound healing, particularly in the early stages of the healing process. This was evidenced by the restoration of the α-helix structure of collagen and the configuration of glycosaminoglycans, as demonstrated by FT-IR absorption bands of the skin both in vivo and ex vivo. Furthermore, the 5% w/w ulvan gel also demonstrated notable efficacy in promoting wound healing, particularly in the later stages of the healing process. These results suggest that carrageenan and ulvan gels hold promise for improving the efficiency of wound healing in second-degree burn wounds. Our study contributes to the understanding of the therapeutic potential of marine polysaccharides and provides insights into their mechanism of action in promoting wound healing. Full article
(This article belongs to the Special Issue Natural Product-Based Biomaterials for Advanced Wound Dressings)
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18 pages, 3793 KiB  
Article
Formulative Study and Characterization of Novel Biomaterials Based on Chitosan/Hydrolyzed Collagen Films
by Tomás Martínez Rodríguez, Caterina Valentino, Francisco Ramón Rodríguez Pozo, Pablo Hernández Benavides, Francisco Arrebola Vargas, José Manuel Paredes, Claro Ignacio Sainz-Díaz, Guillermo R. Iglesias, Silvia Rossi, Giuseppina Sandri, María del Mar Medina Pérez and Carola Aguzzi
J. Funct. Biomater. 2024, 15(3), 69; https://doi.org/10.3390/jfb15030069 - 11 Mar 2024
Cited by 1 | Viewed by 1832
Abstract
To date, the need for biomaterials capable of improving the treatment of chronic skin wounds remains a clinical challenge. The aim of the present work is to formulate and characterize chitosan (Cs)/hydrolyzed collagen (HC) films as potential biomaterials with improved mechanical and hydration [...] Read more.
To date, the need for biomaterials capable of improving the treatment of chronic skin wounds remains a clinical challenge. The aim of the present work is to formulate and characterize chitosan (Cs)/hydrolyzed collagen (HC) films as potential biomaterials with improved mechanical and hydration performances compared to single component formulations. Films were made by the solvent casting method, with or without glycerin and/or PEG1500 as plasticizers, resulting in a total of eight formulations. All films were characterized by their physico-chemical characteristics and their mechanical and hydration features. A full factorial design was also used to statistically assess the effect of HC concentration, type and concentration of plasticizers and their possible interactions on mechanical and swelling behaviors. Solid state characterization confirmed the hybrid nature of the films, with suggested electrostatic interactions between Cs and HC. Mechanical and swelling properties, along with the analysis of the experimental design, allowed the identification of formulations containing high HC concentration (2% w/v) and glycerin or glycerin/PEG1500 as more suitable candidates for skin wound treatment. Finally, viability assay of immortalized human keratinocytes (HaCaT) showed no statistical differences in cell survival compared to the complete culture medium, suggesting their potential as a promising tool for biomedical applications. Full article
(This article belongs to the Special Issue Natural Product-Based Biomaterials for Advanced Wound Dressings)
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