Biodegradable Scaffolds
A special issue of Journal of Functional Biomaterials (ISSN 2079-4983).
Deadline for manuscript submissions: closed (27 June 2017) | Viewed by 38280
Special Issue Editor
Interests: bone tissue engineering; bone grafting materials; resorbable bioactive ceramics; translation; bioceramic scaffolds; cell and tissue reponse; percutaneous devices
Special Issue Information
Dear Colleagues,
Over the last two decades, tissue-engineering concepts for the repair or replacement of damaged tissues or whole organs have been fervently pursued in various medical disciplines. This has resulted in an ever-increasing need for adequate tissue engineering scaffolds. Ideally, a scaffold should first support, promote and guide tissue formation and then resorb, resulting in replacement of the scaffold by functional tissue. Consequently, increasing research efforts have focused on developing biodegradable scaffolds, the respective biomaterials, as well suitable fabrication technologies. In this context, 3D printing has emerged as an important technology, and rapid progress has been made with increasing the quality and versatility of both the printers, as well as the printing process. While 3D printing became first available for use with polymer-based biomaterials, in recent years, this technology has been adapted to also facilitate printing ceramic and metal-based biomaterials. At the same time, 3D printing provides the possibility of fabricating patient-specific implants and scaffolds by utilizing the patient’s CT or MRI data for generating the respective STL file. This is in addition to biomaterial modification and functionalization by ion doping and others when using printers with dual print heads. Other fabrication technologies include electrospinning, selective laser sintering, extrusion-based technologies, stereolithography, and more. Moreover, biodegradable scaffolds for tissue engineering are often combined with different types of cells or stem cells to achieve repair and regeneration of large tissue defects of organs. This required developing adequate cell isolation and dynamic culturing techniques, as well as bioreactors, for achieving homogenous cell growth and differentiation in and on 3D scaffolds, which also constitutes an important area of research. This Special Issue aims at considering all aspects of the fabrication, architecture, and properties of biodegradable scaffolds as well as of the selection and optimization of the respective biomaterials for various clinical applications. This entails identifying the most suitable scaffold and biomaterial architecture and properties for interacting with cells, body fluids and tissues in a manner that leads to enhanced cell function, tissue formation and tissue and organ repair, while ensuring adequate vascularization at the same time.
Prof. Dr. Christine Knabe-Ducheyne
Guest Editor
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Keywords
- Tissue engineering
- Bioactive resorbable ceramics
- Biodegradable polymers
- Biomaterial functionalisation
- Scaffold architectuire
- 3D printing
- Stem cells
- Regnerative medicine
- Soft tissue regeneration
- Musculoskeletal tissue regeneration
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