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Advanced Nanotechnology and Drug Delivery
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Advanced Nanotechnology and Drug Delivery

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983). This special issue belongs to the section "Biomaterials for Drug Delivery".

Deadline for manuscript submissions: closed (20 February 2023) | Viewed by 4658

Special Issue Editors

Prof. Dr. Hongjun Li

E-Mail Website
Guest Editor
College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China
Interests: cancer immunotherapy; drug delivery; cell therapy; CAR T cell delivery; nanomedicine; biomaterials
Dr. Zhiting Cao

E-Mail Website
Guest Editor
School of Biopharmacy, China Pharmaceutical University, Nanjing, China
Interests: block copolymers; cell/bacteria-derived materials; gene delivery; bacteria therapy; smart materials; nanomedicine
Dr. Caoyun Ju

E-Mail Website
Guest Editor
State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, Center of Advanced Pharmaceuticals and Biomaterials, China Pharmaceutical University, Nanjing 210009, China
Interests: targeted drug delivery; stimuli responsive nanosystems; cell therapy; gene delivery; lipid nanoparticles

Special Issue Information

Dear Colleagues,

Functional materials combined with nanotechnology may lead to exciting advances in drug delivery, tissue regeneration, and disease diagnosis. With the rapid development of emerging techniques, such as cell/bacterial-based cancer immunotherapy, near-infrared II window imaging, and controllable nanofabrication, there is also a tremendous need for novel opinions in the design of functional biomaterials. The aim of this Special Issue is to develop more advanced nanotechnology and functional biomaterials for drug delivery and relative applications. Both research and review articles focusing on advanced nanotechnology and drug delivery are welcome.

The Special Issue contents are expected to include:

  • Nanotechnology for cancer immunotherapy;
  • Nanotechnology for disease diagnosis;
  • Advanced drug delivery systems.

Prof. Dr. Hongjun Li
Dr. Zhiting Cao
Dr. Caoyun Ju
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • functional biomaterials
  • drug delivery
  • nanofabrication
  • biomimetic drugs
  • cancer immunotherapy

Published Papers (2 papers)

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Research

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26 pages, 5596 KiB  
Article
PEGylated Strontium Sulfite Nanoparticles with Spontaneously Formed Surface-Embedded Protein Corona Restrict Off-Target Distribution and Accelerate Breast Tumour-Selective Delivery of siRNA
by Md. Emranul Karim and Ezharul Hoque Chowdhury
J. Funct. Biomater. 2022, 13(4), 211; https://doi.org/10.3390/jfb13040211 - 1 Nov 2022
Cited by 2 | Viewed by 1908
Abstract
As transporters of RNAi therapeutics in preclinical and clinical studies, the application of nanoparticles is often hindered by their susceptibility to opsonin-mediated clearance, poor biological stability, ineffectual targeting, and undesirable effects on healthy cells. Prolonging the blood circulation time while minimizing the off-target [...] Read more.
As transporters of RNAi therapeutics in preclinical and clinical studies, the application of nanoparticles is often hindered by their susceptibility to opsonin-mediated clearance, poor biological stability, ineffectual targeting, and undesirable effects on healthy cells. Prolonging the blood circulation time while minimizing the off-target distribution and associated toxicity is indispensable for the establishment of a clinically viable delivery system for therapeutic small interfering RNAs (siRNAs). Herein, we report a scalable and straightforward approach to fabricate non-toxic and biodegradable pH-responsive strontium sulfite nanoparticles (SSNs) wrapped with a hydrophilic coating material, biotinylated PEG to lessen unforeseen biological interactions. Surface functionalization of SSNs with PEG led to the generation of small and uniformly distributed particles with a significant affinity towards siRNAs and augmented internalization into breast cancer cells. A triple quadrupole liquid chromatography-mass spectrometry (LC-MS) was deployed to identify the proteins entrapped onto the SSNs, with the help of SwissProt.Mus_musculus database. The results demonstrated the reduction of opsonin proteins adsorption owing to the stealth effect of PEG. The distribution of PEGylated SSNs in mice after 4 h and 24 h of intravenous administration in breast tumour-bearing mice was found to be significantly less to the organs of the reticuloendothelial system (RES) and augmented accumulation in the tumour region. The anti-EGFR siRNA-loaded PEG-SSNs exerted a significant inhibitory effect on tumour development in the murine breast cancer model without any significant toxicity to healthy tissues. Therefore, PEGylated SSNs open up a new avenue for tumour-selective efficient delivery of siRNAs in managing breast cancer. Full article
(This article belongs to the Special Issue Advanced Nanotechnology and Drug Delivery)
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Review

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22 pages, 6245 KiB  
Review
Precise Design Strategies of Nanotechnologies for Controlled Drug Delivery
by Shiyi Huang and Xianting Ding
J. Funct. Biomater. 2022, 13(4), 188; https://doi.org/10.3390/jfb13040188 - 14 Oct 2022
Cited by 3 | Viewed by 2151
Abstract
Rapid advances in nanotechnologies are driving the revolution in controlled drug delivery. However, heterogeneous barriers, such as blood circulation and cellular barriers, prevent the drug from reaching the cellular target in complex physiologic environments. In this review, we discuss the precise design of [...] Read more.
Rapid advances in nanotechnologies are driving the revolution in controlled drug delivery. However, heterogeneous barriers, such as blood circulation and cellular barriers, prevent the drug from reaching the cellular target in complex physiologic environments. In this review, we discuss the precise design of nanotechnologies to enhance the efficacy, quality, and durability of drug delivery. For drug delivery in vivo, drugs loaded in nanoplatforms target particular sites in a spatial- and temporal-dependent manner. Advances in stimuli-responsive nanoparticles and carbon-based drug delivery platforms are summarized. For transdermal drug delivery systems, specific strategies including microneedles and hydrogel lead to a sustained release efficacy. Moreover, we highlight the current limitations of clinical translation and an incentive for the future development of nanotechnology-based drug delivery. Full article
(This article belongs to the Special Issue Advanced Nanotechnology and Drug Delivery)
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