Natural Products and Nanomaterials: A Promising Synergy for Wound Healing

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983).

Deadline for manuscript submissions: closed (31 August 2020) | Viewed by 7020

Special Issue Editors

Special Issue Information

Dear Colleagues,

The wound healing process is a well-orchestrated physiological process to restore the integrity of the skin and subcutaneous tissue.

Some natural compounds, i.e. complex chemical molecules found in plants and micro-organisms, have biological activities that provide therapeutic benefits that boost wound healing.

Nanotechnology is emerging as one of the most promising tools for creating high performance and multifunctional materials for various industrial and medical applications.

Nanotechnology has demonstrated its capability to manipulate particles and materials in order to target specific areas of the body and control the release of drugs, in particular for wound healing and tissue regeneration.

The development of nano-technological methods can help to improve the efficacy of different therapeutics as well as natural compound-based products.

The aim of this Special Issue is to highlight the most recent results in the field of the biological properties of natural products utilized for nanomaterial production and/or functionalization, and it is also dedicated to the identification and characterisation of new biological active compounds, as well as the cellular and molecular mechanisms involved in the wound healing potential of natural compound-based nanostructured wound dressings.

Studies dealing with the processing of natural products and molecules in order to standardise nanomaterials formulation for wound usage are also welcome.

Dr. Elia Ranzato
Dr. Simona Martinotti
Guest Editors

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Keywords

  • natural products
  • nanomaterials
  • wound healing
  • tissue regeneration

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Published Papers (1 paper)

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Research

15 pages, 2924 KiB  
Communication
In Situ Crosslinking Bionanocomposite Hydrogels with Potential for Wound Healing Applications
by Federica Leone, Melike Firlak, Kirsty Challen, Wayne Bonnefin, Barbara Onida, Karen L. Wright and John G. Hardy
J. Funct. Biomater. 2019, 10(4), 50; https://doi.org/10.3390/jfb10040050 - 14 Nov 2019
Cited by 9 | Viewed by 6480
Abstract
In situ forming hydrogels are a class of biomaterials that can fulfil a variety of important biomedically relevant functions and hold promise for the emerging field of patient-specific treatments (e.g., cell therapy, drug delivery). Here we report the results of our investigations on [...] Read more.
In situ forming hydrogels are a class of biomaterials that can fulfil a variety of important biomedically relevant functions and hold promise for the emerging field of patient-specific treatments (e.g., cell therapy, drug delivery). Here we report the results of our investigations on the generation of in situ forming hydrogels with potential for wound healing applications (e.g., complex blast injuries). The combination of polysaccharides that were oxidized to display aldehydes, amine displaying chitosan and nanostructured ZnO yields in situ forming bionanocomposite hydrogels. The physicochemical properties of the components, their cytotoxicity towards HaCat cells and the in vitro release of zinc ions on synthetic skin were studied. The in situ gel formation process was complete within minutes, the components were non-toxic towards HaCat cells at functional levels, Zn2+ was released from the gels, and such materials may facilitate wound healing. Full article
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