Journal of Functional Biomaterials, Volume 16, Issue 3

Nanoparticles are proposed as alternatives to traditional antimicrobial agents. By manipulating a nanoparticle’s core and surface coating, antimicrobial effects against various microbial populations can be customized, known as the “design...

This research aims to study the antibacterial coatings of invasive surgical medical devices, including dental implants, to reduce superficial and deep local infections over the long term. To obtain the coating without altering the initial properties...

The objective of this review is to investigate the effect of an additional layer of flowable composite for cavity lining on the clinical outcome of direct posterior composite restorations. The PICO question (patient, intervention, comparison, and out...

We are committed to writing this narrative review given that carbon-based nanomaterials are revolutionizing dental medicine. Since the groundbreaking discovery of carbon nanotubes in 1991, their dental applications have skyrocketed. The numbers speak...

Loss of implant function is a common complication in orthopaedic and dental surgery. Among the primary causes of implant failure are peri-implant infections which often result in implant removal. This study demonstrates the development of a new antim...

Background: Oral cancer is an aggressive malignancy with modest survival rates. It also causes disfigurement following surgical removal of the tumor, thus highlighting the need for new cancer treatment and tissue repair modalities. Carbon-based nanom...

Dental implants rely on precise prosthetic design and biomechanical stability to ensure long-term success. This study evaluates the mechanical performance of non-engaging abutments in multi-unit combined screw- and cement-retained prostheses (CSCRP)...

Polyetherketoneketone (PEKK) exhibits satisfactory mechanical properties and biocompatibility, with an elastic modulus closely resembling that of natural bone. This property reduces the stress-shielding effect associated with bone implants. However,...

The rising demand for organ transplants and the need for precise tissue models have positioned the in vitro biomanufacturing of tissues and organs as a pivotal area in regenerative treatment. Considerable development has been achieved in growing tiss...

This comprehensive review of dental resin adhesives explores their historical development, key components, recent innovations, and potential future directions, highlighting a dynamic and continually advancing field. From Buonocore’s breakthroug...

This study aimed to evaluate the effect of pixel offset adjustments in digital light processing (DLP) three-dimensional (3D) printing on the marginal and internal fit and surface trueness of zirconia crowns. Zirconia crowns were designed using dental...

This animal study compared the healing performance of a novel implant design characterized by a shift in thread geometry and core diameter with two different surfaces with that of an apically tapered implant. Test Bioactive (n = 9), Test Porous (n =...

Although dental resin composite restoratives offer a widely used direct-placement treatment option aimed at replacing the form and function of a natural tooth, there are several clinically relevant performance aspects of these materials that can be i...

Hierarchical porous hydrogels possess advantageous characteristics that facilitate cell adhesion, promote tissue growth, and enhance angiogenesis and osteogenesis. In this study, porous composite hydrogels were successfully prepared by a two-step gel...

The periodontal ligament (PDL) is a fibrous connective tissue that anchors the tooth-root surface to the alveolar bone with specific orientations. It plays a crucial role in functional restoration, optimal position stabilities, biomechanical stress t...

Abnormal expression of miRNAs is associated with the occurrence and progression of cancer and other diseases, making miRNAs essential biomarkers for disease diagnosis and prognosis. However, the intrinsic properties of miRNAs, such as short length, l...

Zone II flexor digitorum profundus (FDP) tendon injuries are complex, and present significant challenges in hand surgery, due to the need to balance strength and flexibility during repair. Traditional suture techniques often lead to complications suc...

This study assessed the changes in the mechanical and surface properties of the transition zone in multilayered translucent monolithic zirconia subjected to long-term hydrothermal aging. A total of 360 disk-shaped specimens (diameter: 15.0 mm; thickn...

The aim of this study was to compare the efficacy of the guided tissue regeneration (GTR) of periodontal infrabony defects using the frozen radiation-sterilized allogenic bone graft (FRSABG) versus deproteinized bovine bone mineral (DBBM) 5 years aft...

Periodontitis is accompanied by inflammation that causes dysregulation of the Wnt/β-catenin and TGF-β signaling pathways. This leads to a violation of the homeostasis of periodontal tissues. Components of the extracellular matrix (ECM) are...

(1) Background: Early-stage bone resorption following implant placement can significantly impact the long-term success of implants. This study evaluates whether a fully digitally planned implant position based on the E-point concept, along with guide...

(1) Background: Knee cartilage injury is at the top of the rising concerns among bone and joint disorder patients. Autologous chondrocyte implantation (ACI) is widely used to approach knee cartilage deterioration. Integrating autologous chondrocytes...

Chronic wound infections present a persistent medical challenge; however, advancements in wound dressings and antimicrobial nanomaterials offer promising solutions for improving healing outcomes. This study introduces a hydrothermal synthesis approac...

Osteomyelitis, a severe bone infection, poses a significant therapeutic challenge in both human and veterinary medicine, especially due to the increasing prevalence of antibiotic-resistant pathogens like methicillin-resistant Staphylococcus aureus (M...

Background: Fluorescent gold nanoclusters conjugated with α-lipoic acid (FANCs) have shown great promise for drug development. In a previous study, FANCs did not show any acute or subacute toxicity under 0.6–20 μM/100 μL/25 g body w...

Bacterial resistance and the demand for novel antibacterial strategies represent major challenges in contemporary medicine. In this study, zinc-doped hydroxyapatite (Zn-HA) samples with 3, 5, and 10 wt% Zn(II) were synthesized using wet precipitation...

There is continuing interest in using biologics in root coverage procedures. The aim of the present study was to explore the 2-year outcomes following multiple gingival recessions (GRs) coverage using the application of cross-linked hyaluronic acid (...

Hemorrhage, particularly non-compressible torso bleeding, remains the leading cause of preventable death in trauma. Self-propelling hemostats composed of thrombin-calcium carbonate (CaCO₃) particles and protonated tranexamic acid (TXA⁺) have been sho...

Microcapsules provide a microenvironment by improving the protection and delivery of cells and drugs to specific tissue areas, promoting cell integration and tissue regeneration. Effective microcapsules must not only be permeable for micronutrient di...

Knee osteoarthritis (KOA) is a major cause of pain and disability worldwide, with no current treatment modality able to prevent the progressive destruction of articular cartilage. Mesenchymal stem cells (MSCs) have attracted interest in treating KOA...

Infection control and bone regeneration remain critical challenges in bone defect treatment. We developed a 3D-printed scaffold incorporating copper-based metal–organic framework-74 (Cu-MOF-74) within a polycaprolactone/hydroxyapatite composite...

(1) The aim of this in vitro study was to investigate the handling of proximal-cervical undermined enamel margins on the adhesive performance of differently fabricated and differently cemented ceramic inlays and partial crowns (2) Methods: 192 extrac...

Acellular tissue matrices of fish skin origin are highly promising materials for tissue engineering due to their low biological risks and few religious restrictions. The main component of acellular fish skin matrices (AFSMs) is collagen, but collagen...

Polymer-based scaffolds have emerged as transformative materials in regenerative dentistry, enabling the restoration and replacement of dental tissues through tissue engineering approaches. These scaffolds, derived from natural and synthetic polymers...

The use of blood plasma, fibrinogen or fibrin, a natural biomaterial, has been widely studied for the development of different skin tissue-engineered products and other dermatological treatments. This systematic review reports the preclinical and cli...

Orthodontic microimplants have revolutionized anchorage in orthodontics but remain vulnerable to microbial colonization, potentially leading to infection and failure. Surface modifications incorporating silver nanoparticles (AgNPs) offer antimicrobia...

The global increase in osteomuscular diseases, particularly bone defects and fractures, has driven the growing demand for metallic implants. Additive manufacturing (AM) has emerged as a transformative technology for producing high-precision metallic...

The pontic design may influence the load-to-failure performance of fixed implant-supported screw-retained monolithic zirconia prostheses. This study aimed to evaluate the effect of pontic geometry on the fracture resistance of such restorations. Fort...

Hydroxyapatite (HAP) inserts minimize restoration contraction by constituting a major part of the restoration; however, their effect on the relaxation of tooth tissues has not been previously tested. Finite element analysis was employed to estimate s...

Head and neck squamous cell carcinoma (HNSCC) presents significant challenges in oncology due to its complex biology and poor prognosis. Traditional two-dimensional (2D) cell culture models cannot replicate the intricate tumor microenvironment, limit...

This article reviews the topic of stannous fluoride as an anti-caries additive in toothpastes. It is based on a literature survey carried out using Science Direct, supplemented by information from PubMed. The keywords used were stannous fluoride, too...

Cell migration of mesenchymal stem cells (MSCs) is critical for bone healing and remodeling. Cobalt is a well-known hypoxia mimic, which can enhance MSC migration. Therefore, the objective of this study was to investigate the migratory response of MS...