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Tribology for Biomedical Applications
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Tribology for Biomedical Applications

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983). This special issue belongs to the section "Bone Biomaterials".

Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 17141

Special Issue Editors

Dr. Jian Song

E-Mail Website
Guest Editor
School of Biomedical Engineering, Sun Yat-Sen University, Shenzhen, China
Interests: biotribology; biomaterials; biofabrication; orthopedic implants
Dr. Yuhong Liu

E-Mail Website
Guest Editor
Department of Mechanical Engineering, Tsinghua University, Beijing, China
Interests: nanotribology; nanostructure and nanotechnology of surface and interface; chemical–mechanical planarization; water-based lubrication
Dr. Benjamin Winkeljann

E-Mail Website
Guest Editor
Department of Pharmacy, Ludwig-Maximilians-University (LMU) Munich, Munich, Germany
Interests: functional macromolecules; molecular dynamics simulations; biotribology

Special Issue Information

Dear Colleagues,

As biomaterials science and engineering has progressed quickly over the past decades, the development of this field has shifted to the design of new materials and devices wherein the functionality, reliability, and biocompatibility have become more specific and significant. Tribology-related behavior is one of the key points for the above aspects. For instance, The major clinical problem associated with artificial joints is excessive wear and loosening, which can be attributed to their poor tribological properties and thus generated wear debris. In addition, narrowing or blockage of artificial vascular due to surface coagulation and damage to artificial heart valves owing to fatigue wear are also examples of the failure of biomaterials and medical devices in tribology.

Therefore, to assure the functionality, reliability, and biocompatibility of biomaterials, especially for long-term implanted medical devices, studying various tribological damage mechanisms and obtaining optimum properties is one of the most important goals. Driven by this point, more and more investigations have been conducted on fundamental theories, bionic design, damage palliative related to tribology in biomedical applications. Progress has been achieved, but problems remain to be answered. This is a challenging but attractive task.

In this Special Issue, we invite researchers to provide original research articles, as well as review articles focusing on multiple issues, such as the obtainment, characterization, structure, and original aspects about tribological performances of biomaterials, possibly revealing novel design technologies, advantages, disadvantages, and their various biomedical applications.

Dr. Jian Song
Dr. Yuhong Liu
Dr. Benjamin Winkeljann
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biotribology
  • lubrication
  • wear
  • friction
  • biomaterials
  • biomedical applications

Published Papers (6 papers)

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Research

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16 pages, 5989 KiB  
Article
A Comparison of Wear Patterns on Retrieved and Simulator-Tested Total Knee Replacements
by Rebecca H. Dammer, Carmen Zietz and Rainer Bader
J. Funct. Biomater. 2022, 13(4), 256; https://doi.org/10.3390/jfb13040256 - 19 Nov 2022
Cited by 1 | Viewed by 1542
Abstract
Aseptic implant loosening is the most common reason for revision surgery after total knee replacement. This is associated with adverse biological reactions to wear debris from the articulating implant components. To predict the amount of wear debris generated in situ, standard wear testing [...] Read more.
Aseptic implant loosening is the most common reason for revision surgery after total knee replacement. This is associated with adverse biological reactions to wear debris from the articulating implant components. To predict the amount of wear debris generated in situ, standard wear testing of total knee replacement (TKR) is carried out before its clinical use. However, wear data reported on retrievals of total knee replacement (TKR) revealed significant discrepancies compared with standard wear simulator studies. Therefore, the aim of the present study was to compare the wear patterns on identical posterior-cruciate-retaining TKR designs by analyzing retrieved and experimentally tested implants. The identification and classification of wear patterns were performed using 21 retrieved ultra-high-molecular-weight-polyethylene (UHMW-PE) inserts and four sets of inserts of identical design and material tested in a knee wear simulator. These four sets had undergone different worst-case conditions and a standard test in a wear simulator according to ISO 14243-1. Macroscopic and microscopic examinations of the polyethylene inserts were performed, including the determination of seven modes of wear that correspond to specific wear patterns, the calculation of wear areas, and the classification of the damage over the whole articulating area. Retrieved and standard wear simulator-tested UHMW-PE inserts showed significant differences in wear area and patterns. The total wear areas and the damage score were significantly larger on the retrievals (52.3% versus 23.9%, 32.7 versus 22.7). Furthermore, the range of wear patterns found on the retrievals was not reproducible in the simulator-tested inserts. However, good correspondence was found with the simulator-tested polyethylene inserts under worst-case conditions (third body wear), i.e., deep wear areas could be replicated according to the in vivo situation compared with other wear test scenarios. Based on the findings presented here, standard simulator testing can be used to directly compare different TKR designs but is limited in the prediction of their in situ wear. Preclinical wear testing may be adjusted by worst-case conditions to improve the prediction of in situ performance of total knee implants in the future. Full article
(This article belongs to the Special Issue Tribology for Biomedical Applications)
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11 pages, 5247 KiB  
Article
Computational Contact Pressure Prediction of CoCrMo, SS 316L and Ti6Al4V Femoral Head against UHMWPE Acetabular Cup under Gait Cycle
by J. Jamari, Muhammad Imam Ammarullah, Gatot Santoso, S. Sugiharto, Toto Supriyono, Akbar Teguh Prakoso, Hasan Basri and Emile van der Heide
J. Funct. Biomater. 2022, 13(2), 64; https://doi.org/10.3390/jfb13020064 - 23 May 2022
Cited by 86 | Viewed by 4339
Abstract
Due to various concerns about the use of metal-on-metal that is detrimental to users, the use of metal as acetabular cup material was later changed to ultra high molecular weight polyethylene (UHMWPE). However, the wear on UHMWPE releases polyethylene wear particles, which can [...] Read more.
Due to various concerns about the use of metal-on-metal that is detrimental to users, the use of metal as acetabular cup material was later changed to ultra high molecular weight polyethylene (UHMWPE). However, the wear on UHMWPE releases polyethylene wear particles, which can trigger a negative body response and contribute to osteolysis. For reducing the wear of polyethylene, one of the efforts is to investigate the selection of metal materials. Cobalt chromium molybdenum (CoCrMo), stainless steel 316L (SS 316L), and titanium alloy (Ti6Al4V) are the frequently employed materials. The computational evaluation of contact pressure was carried out using a two-dimensional axisymmetric model for UHMWPE acetabular cup paired with metal femoral head under gait cycle in this study. The results show Ti6Al4V-on-UHMWPE is able to reduce cumulative contact pressure compared to SS 316L-on-UHMWPE and CoCrMo-on-UHMWPE. Compared to Ti6Al4V-on-UHMWPE at peak loading, the difference in cumulative contact pressure to respective maximum contact pressure is 9.740% for SS 316L-on-UHMWPE and 11.038% for CoCrMo-on-UHMWPE. Full article
(This article belongs to the Special Issue Tribology for Biomedical Applications)
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Review

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17 pages, 2043 KiB  
Review
Metals Biotribology and Oral Microbiota Biocorrosion Mechanisms
by Nicola Contuzzi, Giuseppe Casalino, Antonio Boccaccio, Andrea Ballini, Ioannis Alexandros Charitos, Lucrezia Bottalico and Luigi Santacroce
J. Funct. Biomater. 2023, 14(1), 14; https://doi.org/10.3390/jfb14010014 - 23 Dec 2022
Cited by 11 | Viewed by 2262
Abstract
During the last decades, metal-based biomaterials have been extensively explored to be used as biocompatible metals for biomedical applications, owing to their superior mechanical properties and corrosion resistance. Consequently, for long-term implanted medical devices, to assure the biomaterials’ reliability, functionality, and biocompatibility, studying [...] Read more.
During the last decades, metal-based biomaterials have been extensively explored to be used as biocompatible metals for biomedical applications, owing to their superior mechanical properties and corrosion resistance. Consequently, for long-term implanted medical devices, to assure the biomaterials’ reliability, functionality, and biocompatibility, studying the various bio-tribological damage mechanisms to obtain the optimum properties is one of the most important goals. In this review, we consider the most important metal-based biomaterials such as stainless steel, alloys of titanium (Ti), cobalt-chromium (Co-Cr), and Nichel-Titatium (Ni-Ti), as well Magnesium (Mg) alloys and with Tantalum (Ta), emphasizing their characteristics, clinical applications, and deterioration over time. The influence of metal elements on biological safety, including significant effects of metal-based biomaterials in dentistry were discussed, considering the perspectives of surface, mechanical properties, corrosion behaviors, including interactions, bio-mechanisms with tissues, and oral environments. In addition, the role of the oral microbiota was explored due to its role in this erosion condition, in order to further understand the mechanism of metal-based biomaterials implanted on the microflora balance of aerobic and anaerobic bacteria in an oral environment. Full article
(This article belongs to the Special Issue Tribology for Biomedical Applications)
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21 pages, 3815 KiB  
Review
Recent Developments in Zn-Based Biodegradable Materials for Biomedical Applications
by Muzamil Hussain, Sami Ullah, Muhammad Rafi Raza, Naseem Abbas and Ahsan Ali
J. Funct. Biomater. 2023, 14(1), 1; https://doi.org/10.3390/jfb14010001 - 20 Dec 2022
Cited by 13 | Viewed by 3645
Abstract
Zn-based biodegradable alloys or composites have the potential to be developed to next-generation orthopedic implants as alternatives to conventional implants to avoid revision surgeries and to reduce biocompatibility issues. This review summarizes the current research status on Zn-based biodegradable materials. The biological function [...] Read more.
Zn-based biodegradable alloys or composites have the potential to be developed to next-generation orthopedic implants as alternatives to conventional implants to avoid revision surgeries and to reduce biocompatibility issues. This review summarizes the current research status on Zn-based biodegradable materials. The biological function of Zn, design criteria for orthopedic implants, and corrosion behavior of biodegradable materials are briefly discussed. The performance of many novel zinc-based biodegradable materials is evaluated in terms of biodegradation, biocompatibility, and mechanical properties. Zn-based materials perform a significant role in bone metabolism and the growth of new cells and show medium degradation without the release of excessive hydrogen. The addition of alloying elements such as Mg, Zr, Mn, Ca, and Li into pure Zn enhances the mechanical properties of Zn alloys. Grain refinement by the application of post-processing techniques is effective for the development of many suitable Zn-based biodegradable materials. Full article
(This article belongs to the Special Issue Tribology for Biomedical Applications)
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20 pages, 978 KiB  
Review
Application of Tribology Concept in Dental Composites Field: A Scoping Review
by Giusy Rita Maria La Rosa, Luigi Generali, Calogero Bugea, Hani F. Ounsi, Gergely Benyőcs, Prasanna Neelakantan and Eugenio Pedullà
J. Funct. Biomater. 2022, 13(4), 287; https://doi.org/10.3390/jfb13040287 - 8 Dec 2022
Cited by 3 | Viewed by 1979
Abstract
Tribology is the discipline concerning the application of friction, lubrication, and wear concepts of interacting surfaces in relative motion. A growing interest has developed in tribology application in medical biomaterials, such as resin composites used in restorative dentistry. Yet, the keywords “tribology” and [...] Read more.
Tribology is the discipline concerning the application of friction, lubrication, and wear concepts of interacting surfaces in relative motion. A growing interest has developed in tribology application in medical biomaterials, such as resin composites used in restorative dentistry. Yet, the keywords “tribology” and “biotribology” are little applied in the pertinent publications. The aim of this scoping review was to offer an overview of tribology application in dental composites research and to identify knowledge gaps and address future research. A literature search was conducted on Pubmed and Scopus databases and the studies investigating the tribological behavior of resin composites were included for qualitative synthesis. The majority of studies on dental tribology were published in the research areas of mechanical engineering/nanotechnology and differed in several methodological aspects. The preponderant engineering approach and the lack of standardized testing make the laboratory findings poorly informative for clinicians. Future research should focus on the tribological behavior of dental materials composites by means of an integrated approach, i.e., engineering and clinical, for improving development and advancement in this field of research. Full article
(This article belongs to the Special Issue Tribology for Biomedical Applications)
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Other

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9 pages, 3386 KiB  
Case Report
A Rare Case of Adverse Reaction to Metal Debris in a Ceramic-on-Ceramic Total Hip Replacement
by Adriano Cannella, Tommaso Greco, Chiara Polichetti, Ivan De Martino, Antonio Mascio, Giulio Maccauro and Carlo Perisano
J. Funct. Biomater. 2022, 13(3), 145; https://doi.org/10.3390/jfb13030145 - 8 Sep 2022
Cited by 4 | Viewed by 2260
Abstract
Adverse Reaction to Metal Debris (ARMD) is one of the most frequent complications after Total Hip Replacement (THR) and often a cause of surgical revision. This is true especially for implants with Metal-on-Metal (MoM) and Large Diameter Heads (LDHs), which are frequently used [...] Read more.
Adverse Reaction to Metal Debris (ARMD) is one of the most frequent complications after Total Hip Replacement (THR) and often a cause of surgical revision. This is true especially for implants with Metal-on-Metal (MoM) and Large Diameter Heads (LDHs), which are frequently used to improve stability and reduce the risk of dislocation. However, ARMD is not exclusive to MoM replacement, as it can also occur in other implants such Ceramic-on-Ceramic (CoC), Metal-on-Polyethylene (MoP), and Ceramic-on-Polyethylene (CoP). In these non-MoM implants, ARMD is not caused by the tribo-corrosion between bearing surfaces but, rather, by the fretting at the interface between neck and stem of dissimilar metals. A case of a severe ARMD that happened to a 73-year-old female patient with CoC bearing THR at the right hip is presented in this case report. In this case, the ARMD was misdiagnosed for over a year, resulting in the development of a massive pseudotumor. The treatment of choice was a two-stage revision with the implant of a hip megaprosthesis. After more than 2 years of follow-up, complete recovery of hip Range of Motion (ROM) and normalization of chromium and cobalt levels in blood and urine were achieved. Despite the relatively short follow-up period, this can be considered a successful treatment of a major and misdiagnosed ARMD in a non-MoM hip replacement. Full article
(This article belongs to the Special Issue Tribology for Biomedical Applications)
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