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Feature Papers in Bone Biomaterials
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Feature Papers in Bone Biomaterials

A topical collection in Journal of Functional Biomaterials (ISSN 2079-4983). This collection belongs to the section "Bone Biomaterials".

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Editor

Dr. Daniele Botticelli

E-Mail Website
Collection Editor
ARDEC Academy, Viale Giovanni Pascoli 67, 47923 Rimini, Italy
Interests: dental implant; oral surgery; sinus floor elevation; bone volume augmentation; histology
Special Issues, Collections and Topics in MDPI journals

Topical Collection Information

Dear Colleagues, 

This Topical Collection, entitled “Feature Papers in Bone Biomaterials”, of Journal of Functional Biomaterials aims to showcase exceptional contributions from scholars and Editorial Board Members. This collection will feature high-quality research papers and review articles that emphasize innovative and impactful advancements in the field of bone biomaterials. 

The collection will highlight cutting-edge approaches in the development and application of biomaterials for bone regeneration, repair, and augmentation. Topics may include, but are not limited to, the design and optimization of scaffolds, bioceramics, composites, and coatings for implants. Studies addressing key challenges such as enhancing osseointegration, promoting bone tissue regeneration, and mitigating inflammation or infection risks are particularly welcome. 

This curated collection will serve as a valuable resource for researchers, clinicians, and students interested in the forefront of bone biomaterials science. By bringing together the expertise of leading researchers worldwide, these feature papers will provide a comprehensive perspective on the latest innovations and trends in this rapidly advancing field. We look forward to receiving your contributions and thank you for your continued efforts to advance the science and application of bone biomaterials.

Dr. Daniele Botticelli
Collection Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the collection website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bone regeneration
  • scaffolds for bone tissue engineering
  • bone grafts
  • bioceramics
  • implant coatings
  • osteoconduction
  • 3D printing of bone biomaterials
  • nanotechnology in bone biomaterials
  • bone substitute
  • osseointegration

Published Papers (2 papers)

Download All Papers

2025

15 pages, 5200 KiB  
Article
Designing Superhydrophilic 3D Porous Surfaces on Polyetherketoneketone Surfaces to Promote Biocompatibility
by Hui-Ching Lin, Chiang-Sang Chen, Kai-Yi Lin, Ya-Lin Huang, Hao-Hsiang Hsu, Yu-Lin Kuo, Wei-Cheng Chen and Her-Hsiung Huang
J. Funct. Biomater. 2025, 16(3), 106; https://doi.org/10.3390/jfb16030106 - 14 Mar 2025
Viewed by 432
Abstract
Polyetherketoneketone (PEKK) exhibits satisfactory mechanical properties and biocompatibility, with an elastic modulus closely resembling that of natural bone. This property reduces the stress-shielding effect associated with bone implants. However, the biological inertness of the PEKK surface remains a significant limitation for its application [...] Read more.
Polyetherketoneketone (PEKK) exhibits satisfactory mechanical properties and biocompatibility, with an elastic modulus closely resembling that of natural bone. This property reduces the stress-shielding effect associated with bone implants. However, the biological inertness of the PEKK surface remains a significant limitation for its application in bone tissue engineering. The objective of this study was to create a superhydrophilic 3D porous structure on the surface of PEKK to enhance biocompatibility, in terms of vascularization and bone remodeling. A combination of mechanical, chemical, and physical surface treatments was employed to modify the PEKK surface. Initially, mechanical sandblasting was used to create a rough surface to promote mechanical interlocking with bone tissue. Subsequently, chemical acid etching and physical low-temperature atmospheric plasma cleaning were applied to develop a superhydrophilic 3D porous surface. The modified surfaces were characterized for morphology, roughness, hydrophilicity, and functional groups. Cellular responses, including vascularization and bone remodeling, were evaluated to assess the potential for improved biocompatibility. The combination of acid etching and low-temperature atmospheric plasma cleaning, with or without prior sandblasting, successfully created a superhydrophilic 3D porous structure on the PEKK surface. This modified surface enhanced the tube formation in human umbilical vein endothelial cells. It also promoted the adhesion and mineralization of human bone marrow mesenchymal stem cells and slightly reduced tartrate-resistant acid phosphatase expression and F-actin ring size in mouse macrophage cells. This study introduces an innovative and effective surface modification strategy for PEKK surface, combining mechanical, chemical, and physical treatments to enhance biocompatibility. The modified PEKK surface promotes angiogenic and osteogenic responses while slightly inhibiting osteoclastic activity, making it a potential alternative for dental and orthopedic PEKK implant applications. Full article
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17 pages, 8139 KiB  
Article
Long-Term Stability and Osteogenic Activity of Recycled Polysulfone-Calcium Silicate Bone Implants In Vitro
by Chi-Nan Chang, Yun-Ru Huang and Shinn-Jyh Ding
J. Funct. Biomater. 2025, 16(1), 31; https://doi.org/10.3390/jfb16010031 - 17 Jan 2025
Viewed by 761
Abstract
Environmental protection issues have received widespread attention, making material recycling increasingly important. The upcycling of polysulfone (PSF) medical waste, recognized as a high-performance plastic with excellent mechanical properties, deserves promotion. While PSF is suitable for use as an orthopedic implant material, such as [...] Read more.
Environmental protection issues have received widespread attention, making material recycling increasingly important. The upcycling of polysulfone (PSF) medical waste, recognized as a high-performance plastic with excellent mechanical properties, deserves promotion. While PSF is suitable for use as an orthopedic implant material, such as internal fixation, its osteogenesis capabilities must be enhanced. Mechanical stability, particularly over the long term, is a significant concern for bone implants in load-bearing applications. This study recycled PSF medical waste to create bone composites by incorporating osteogenic calcium silicate (CaSi) at three different contents: 10%, 20%, and 30%. We evaluated the phase, morphology, weight loss, and three-point bending strength of the PSF-based composites after they were soaked in dynamic simulated body fluid (SBF) at pH levels of 7.4 and 5.0 for up to 12 months. Human mesenchymal stem cells (hMSCs) were utilized to assess the osteogenic activity of these composites. Our findings revealed that, while the bending strength of PSF-based composites declined with prolonged exposure to SBF, the dissolution of CaSi particles led to a manageable weight loss of about 4% after 12 months, regardless of pH 7.4 or 5.0. Importantly, the incorporation of CaSi into the PSF matrix exhibited a positive effect on the attachment and proliferation of hMSCs. The levels of alkaline phosphatase (ALP) and calcium deposits directly correlated with the CaSi content, indicating superior osteogenic activity. Considering biostability and osteogenic ability, the 20% CaSi-PSF composite demonstrated promise as a candidate for load-bearing implant applications. Full article
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